Title:
TRANSLATION INHIBITOR NOT OCCUPYING RIBOSOME RESOURCE AS ANTITUMOR DRUG
Document Type and Number:
WIPO Patent Application WO/2023/138011
Kind Code:
A1
Abstract:
The present invention provides a translation inhibitor not occupying a ribosome resource. The translation inhibitor not occupying a ribosome resource shows a good antitumor effect, has high safety, and can be used for preparing an antitumor drug.
Inventors:
ZHANG GONG (CN)
CHEN YANG (CN)
YU ZHUO (CN)
CHEN YANG (CN)
YU ZHUO (CN)
Application Number:
PCT/CN2022/106988
Publication Date:
July 27, 2023
Filing Date:
July 21, 2022
Export Citation:
Assignee:
CHI BIOTECH CO LTD (CN)
International Classes:
A61K31/58; A61K31/235; A61K31/7034; A61K45/06; A61P35/00
Domestic Patent References:
| WO2021001743A1 | 2021-01-07 |
Foreign References:
| CN114404400A | 2022-04-29 | |||
| US20190211339A1 | 2019-07-11 | |||
| US4007270A | 1977-02-08 | |||
| CN110638802A | 2020-01-03 | |||
| US20100130359A1 | 2010-05-27 |
Other References:
SHEN LEO, PELLETIER JERRY: "Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products", NATURAL PRODUCT REPORTS, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 37, no. 5, 27 May 2020 (2020-05-27), GB , pages 609 - 616, XP093079841, ISSN: 0265-0568, DOI: 10.1039/C9NP00052F
NAINEI SAI KIRAN, ITOUA MAÏGA RAYELLE, CENCIC REGINA, PUTNAM ANDREA A, AMADOR LUIS A, RODRIGUEZ ABIMAEL D, JANKOWSKY ECKHARD, PELL: "A Comparative Study of Small Molecules Targeting eIF4A", RNA, COLD SPRING HARBOR LABORATORY PRESS, US, vol. 26, no. 5, 3 February 2020 (2020-02-03), US , pages 541 - 549, XP093079845, ISSN: 1355-8382, DOI: 10.1261/rna
NAINEI SAI KIRAN, ITOUA MAÏGA RAYELLE, CENCIC REGINA, PUTNAM ANDREA A, AMADOR LUIS A, RODRIGUEZ ABIMAEL D, JANKOWSKY ECKHARD, PELL: "A Comparative Study of Small Molecules Targeting eIF4A", RNA, COLD SPRING HARBOR LABORATORY PRESS, US, vol. 26, no. 5, 3 February 2020 (2020-02-03), US , pages 541 - 549, XP093079845, ISSN: 1355-8382, DOI: 10.1261/rna
Attorney, Agent or Firm:
BEIJING WEIZHENG PATENT AGENCY CO., LTD. (CN)
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