Title:
TRANSPLANT MATERIAL AND KIDNEY TRANSPLANT KIT
Document Type and Number:
WIPO Patent Application WO/2022/250147
Kind Code:
A1
Abstract:
This transplant material is to be used in kidney xenotransplantation to a primate and contains a kidney anlage with bladder attached without including any blood vessels derived from a pig embryo.
Inventors:
KOBAYASHI EIJI (JP)
YOKOO TAKASHI (JP)
KIYOSHI AKIHIKO (JP)
KURODA TAKAO (JP)
YOKOO TAKASHI (JP)
KIYOSHI AKIHIKO (JP)
KURODA TAKAO (JP)
Application Number:
PCT/JP2022/021782
Publication Date:
December 01, 2022
Filing Date:
May 27, 2022
Export Citation:
Assignee:
THE JIKEI UNIV (JP)
SUMITOMO PHARMA CO LTD (JP)
BIOS CO LTD (JP)
PORMEDTEC CO LTD (JP)
SUMITOMO PHARMA CO LTD (JP)
BIOS CO LTD (JP)
PORMEDTEC CO LTD (JP)
International Classes:
A61L27/36; A61K39/395; A61K45/06; A61L27/38; A61P1/04; A61P7/00; A61P7/02; A61P31/04; A61P31/12; A61P37/06
Domestic Patent References:
| WO2016098620A1 | 2016-06-23 | |||
| WO2020123825A1 | 2020-06-18 |
Foreign References:
| JP2021069432A | 2021-05-06 | |||
| JP2020517605A | 2020-06-18 | |||
| JP2021090066A | 2021-06-10 |
Other References:
FUJIMOTO TOSHINARI, YAMANAKA SHUICHIRO, TAJIRI SUSUMU, TAKAMURA TSUYOSHI, SAITO YATSUMU, MATSUMOTO NAOTO, MATSUMOTO KEI, TACHIBANA: "Generation of Human Renal Vesicles in Mouse Organ Niche Using Nephron Progenitor Cell Replacement System", CELL REPORTS, ELSEVIER INC, US, vol. 32, no. 11, 1 September 2020 (2020-09-01), US , pages 108130, XP093008468, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2020.108130
HAYATO IWASE, HIDETAKA HARA, MOHAMED EZZELARAB, TAO LI, ZHONGQIANG ZHANG, BINGSI GAO, HONG LIU, CASSANDRA LONG, YI WANG, AMY CASSA: "Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts", XENOTRANSPLANTATION, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 24, no. 2, 1 March 2017 (2017-03-01), US , pages e12293, XP055571105, ISSN: 0908-665X, DOI: 10.1111/xen.12293
KEI MATSUMOTO, TOSHINARI FUJIMOTO, SUSUMU TAJIRI, SHUICHIRO YAMANAKA, YOICHI MIYAZAKI, TAKASHI YOKOO: "Development of differentiation induction method from human iPS cells to kidney using organogenesis niche", JOURNAL OF DEVELOPMENTAL NEPHROLOGY, vol. 27, no. 1, 1 January 2019 (2019-01-01), pages 35 - 39, XP009541403, ISSN: 0919-7532
QI SPENG JXU DVU MDLIU DCHEN H: "improved techniques for kidney transplantation in the monkey", MICROSURGERY, vol. 19, no. 7, 1999, pages 335 - 7
IWASE HHARA HEZZELARAB M ET AL.: "Immunologic and physiologic observations in baboons with life-supporting genetically engineered pig kidney grafts", XENOTRANSPLANTATION, vol. 24, no. 2, 2017
HIGGINBOTHAM LMATHEWS DBREEDEN CA ET AL.: "Pre-transplant antibody screening and anti-CD 154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model", XENOTRANSPLANTATION, vol. 22, no. 3, 2015, pages 221 - 230
KIM SCMATHEWS DVBREEDEN CP ET AL.: "Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T cell depletion", AM J TRANSPLANT, vol. 19, no. 8, 2019, pages 2174 - 2185
XIAO-HUA YU ET AL., CLINICA CHIMICA ACTA, vol. 514, 2021, pages 15 - 23
LU ET AL., FRONTIERS IN IMMUNOLOGY, vol. 10, no. 3060, January 2020 (2020-01-01)
FUJIMOTO TYAMANAKA STAJIRI S ET AL.: "Generation of Human Renal Vesicles in Mouse Organ Niche Using Nephron Progenitor Cell Replacement System", CELL REP, vol. 32, no. 11, 2020, pages 108130, XP093008468, DOI: 10.1016/j.celrep.2020.108130
HAYATO IWASE, HIDETAKA HARA, MOHAMED EZZELARAB, TAO LI, ZHONGQIANG ZHANG, BINGSI GAO, HONG LIU, CASSANDRA LONG, YI WANG, AMY CASSA: "Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts", XENOTRANSPLANTATION, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 24, no. 2, 1 March 2017 (2017-03-01), US , pages e12293, XP055571105, ISSN: 0908-665X, DOI: 10.1111/xen.12293
KEI MATSUMOTO, TOSHINARI FUJIMOTO, SUSUMU TAJIRI, SHUICHIRO YAMANAKA, YOICHI MIYAZAKI, TAKASHI YOKOO: "Development of differentiation induction method from human iPS cells to kidney using organogenesis niche", JOURNAL OF DEVELOPMENTAL NEPHROLOGY, vol. 27, no. 1, 1 January 2019 (2019-01-01), pages 35 - 39, XP009541403, ISSN: 0919-7532
QI SPENG JXU DVU MDLIU DCHEN H: "improved techniques for kidney transplantation in the monkey", MICROSURGERY, vol. 19, no. 7, 1999, pages 335 - 7
IWASE HHARA HEZZELARAB M ET AL.: "Immunologic and physiologic observations in baboons with life-supporting genetically engineered pig kidney grafts", XENOTRANSPLANTATION, vol. 24, no. 2, 2017
HIGGINBOTHAM LMATHEWS DBREEDEN CA ET AL.: "Pre-transplant antibody screening and anti-CD 154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model", XENOTRANSPLANTATION, vol. 22, no. 3, 2015, pages 221 - 230
KIM SCMATHEWS DVBREEDEN CP ET AL.: "Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T cell depletion", AM J TRANSPLANT, vol. 19, no. 8, 2019, pages 2174 - 2185
XIAO-HUA YU ET AL., CLINICA CHIMICA ACTA, vol. 514, 2021, pages 15 - 23
LU ET AL., FRONTIERS IN IMMUNOLOGY, vol. 10, no. 3060, January 2020 (2020-01-01)
FUJIMOTO TYAMANAKA STAJIRI S ET AL.: "Generation of Human Renal Vesicles in Mouse Organ Niche Using Nephron Progenitor Cell Replacement System", CELL REP, vol. 32, no. 11, 2020, pages 108130, XP093008468, DOI: 10.1016/j.celrep.2020.108130
Attorney, Agent or Firm:
IIDA Masato (JP)
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