Title:
TREATED APATITE PARTICLES FOR MEDICAL DIAGNOSTIC IMAGING
Document Type and Number:
WIPO Patent Application WO1993007905
Kind Code:
A3
Abstract:
Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging (37 MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for 19F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the abovedescribed apatite particles and then performing the medical diagnostic procedure.
Inventors:
DEUTSCH EDWARD A (US)
DEUTSCH KAREN F (US)
CACHERIS WILLIAM P (US)
RALSTON WILLIAM P (US)
WHITE DAVID H (US)
WOULFE STEVEN R (US)
DEUTSCH KAREN F (US)
CACHERIS WILLIAM P (US)
RALSTON WILLIAM P (US)
WHITE DAVID H (US)
WOULFE STEVEN R (US)
Application Number:
PCT/US1992/009032
Publication Date:
August 05, 1993
Filing Date:
October 21, 1992
Export Citation:
Assignee:
MALLINCKRODT MEDICAL INC (US)
International Classes:
A61K47/48; A61B5/055; A61K49/00; A61K49/04; A61K49/18; A61K49/22; C01B25/32; C01G28/00; C01G31/00; C01G45/00; C07F9/38; A61B19/00; (IPC1-7): A61K47/48; A61K49/00
Domestic Patent References:
| WO1991012212A1 | 1991-08-22 |
Foreign References:
| EP0210043A2 | 1987-01-28 | |||
| EP0093399A1 | 1983-11-09 | |||
| EP0343934A2 | 1989-11-29 | |||
| EP0361797A1 | 1990-04-04 | |||
| DE1639040B1 | 1970-09-03 | |||
| FR2509611A1 | 1983-01-21 | |||
| FR2568238A1 | 1986-01-31 | |||
| EP0275215A1 | 1988-07-20 |
Other References:
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J EXP BIOL., VOL. 151, PAGE(S) 371-386, 1990, SPARKS, N, H, C. MOTTA, P, J. SHELLIS, R, P. WADE, V, J. MANN, S. 'AN ANALYTICAL ELECTRON MICROSCOPY STUDY OF IRON-RICH TEETH FROM THE BUTTERFLYFISH CHAETODON-ORNATISSIMUS.'
NEUROLOGY., VOL. 25, NO. 1, PAGE(S) 48-57, 1975, SMEYERS, VERBEKE, J. MICHOTTE, Y. PELSMAECKERS, J. ET AL. 'The chemical composition of idiopathic nonarteriosclerotic cerebral calcifications.'
ARCH. PATHOL. LAB. MED., VOL. 109, NO. 9, PAGE(S) 838-842, 1985, ANDERSON, K, A. BURBACH, J, A. FENTON, L, J. ET AL. 'Idiopathic arterial calcification of infancy in newborn siblings with unusual light and electron microscopic manifestations.'
J INORG BIOCHEM., VOL. 45, NO. 2, PAGE(S) 129-134. 1992, MAYER, I. DIAB, H. FELNER, I. 'FERRIC IRON IN SYNTHETIC CARBONATE APATITES A MOESSBAUER EFFECT STUDY.'
OPHTHALMOLOGY., VOL. 95, NO. 1, PAGE(S) 61-68, 1988, FONT, R, L. BERSANI, T, A. EAGLE, R, C JR. 'Malakoplakia of the eyelid: Clinical, histopathologic, and ultrastructural characteristics.'
DEUT. STOMATOL., VOL. 23, NO. 1, PAGE(S) 8-16, 1973, OELZNER, W. ET AL. 'Struktur und Aufbau menschlichen Zahnsteins'
HIROSAKI IGAKU, VOL. 28, NO. 2, PAGE(S) 244-51, 1976, KODERA, MASAKATSU ET AL. 'A study of existing states of carbonate in biological apatite by infrared spectroscopy'
MAGNETIC RESONANCE IMAGING vol. 4, no. 4, 1986, US pages 351 - 357 P.F. RENSHAW ET AL. 'Immunospecific NMR contrast agents.'
J EXP BIOL., VOL. 151, PAGE(S) 371-386, 1990, SPARKS, N, H, C. MOTTA, P, J. SHELLIS, R, P. WADE, V, J. MANN, S. 'AN ANALYTICAL ELECTRON MICROSCOPY STUDY OF IRON-RICH TEETH FROM THE BUTTERFLYFISH CHAETODON-ORNATISSIMUS.'
NEUROLOGY., VOL. 25, NO. 1, PAGE(S) 48-57, 1975, SMEYERS, VERBEKE, J. MICHOTTE, Y. PELSMAECKERS, J. ET AL. 'The chemical composition of idiopathic nonarteriosclerotic cerebral calcifications.'
ARCH. PATHOL. LAB. MED., VOL. 109, NO. 9, PAGE(S) 838-842, 1985, ANDERSON, K, A. BURBACH, J, A. FENTON, L, J. ET AL. 'Idiopathic arterial calcification of infancy in newborn siblings with unusual light and electron microscopic manifestations.'
J INORG BIOCHEM., VOL. 45, NO. 2, PAGE(S) 129-134. 1992, MAYER, I. DIAB, H. FELNER, I. 'FERRIC IRON IN SYNTHETIC CARBONATE APATITES A MOESSBAUER EFFECT STUDY.'
OPHTHALMOLOGY., VOL. 95, NO. 1, PAGE(S) 61-68, 1988, FONT, R, L. BERSANI, T, A. EAGLE, R, C JR. 'Malakoplakia of the eyelid: Clinical, histopathologic, and ultrastructural characteristics.'
DEUT. STOMATOL., VOL. 23, NO. 1, PAGE(S) 8-16, 1973, OELZNER, W. ET AL. 'Struktur und Aufbau menschlichen Zahnsteins'
HIROSAKI IGAKU, VOL. 28, NO. 2, PAGE(S) 244-51, 1976, KODERA, MASAKATSU ET AL. 'A study of existing states of carbonate in biological apatite by infrared spectroscopy'
MAGNETIC RESONANCE IMAGING vol. 4, no. 4, 1986, US pages 351 - 357 P.F. RENSHAW ET AL. 'Immunospecific NMR contrast agents.'
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