Title:
TREATING INFLAMMATORY SKIN DISEASES
Document Type and Number:
WIPO Patent Application WO/2012/172336
Kind Code:
A3
Abstract:
A method for treating inflammatory skin disease comprises applying peripheral blood from a patient to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR4, CXCR1, CXCR2, CCR2, CCR6, CCR3, CCR5, CCR1, CCR9 or ChemR23 immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR4, CXCR1, CXCR2, CCR2, CCR6, CCR3, CCR5, CCR1, CCR9 and ChemR23 expressing cells from the peripheral blood of the patient or subject. Various companion diagnostic methods and useful binding reagents are also described.
Inventors:
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
WINQVIST OLA (SE)
Application Number:
PCT/GB2012/051345
Publication Date:
March 07, 2013
Filing Date:
June 13, 2012
Export Citation:
Assignee:
ITH IMMUNE THERAPY HOLDINGS (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
International Classes:
C07K14/52; A61M1/36; B01J20/32; C07K17/02; G01N33/68
Domestic Patent References:
| WO2007133147A1 | 2007-11-22 | |||
| WO2010029317A2 | 2010-03-18 |
Foreign References:
| DE102005036505A1 | 2006-06-01 | |||
| US20030017979A1 | 2003-01-23 | |||
| US20030215421A1 | 2003-11-20 |
Other References:
ROTTMAN JAMES B ET AL: "Potential role of the chemokine receptors CXCR3, CCR4, and the integrin alphaEbeta7 in the pathogenesis of psoriasis vulgaris", LABORATORY INVESTIGATION, vol. 81, no. 3, March 2001 (2001-03-01), pages 335 - 347, XP002681949, ISSN: 0023-6837
TOMOMI NAKATANI ET AL: "CCR4+ memory CD4+ T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic dermatitis", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 107, no. 2, 1 February 2001 (2001-02-01), pages 353 - 358, XP055035429, ISSN: 0091-6749, DOI: 10.1067/mai.2001.112601
Y. TERAKI ET AL: "Homing receptor and chemokine receptor on intraepidermal T cells in psoriasis vulgaris", CLINICAL AND EXPERIMENTAL DERMATOLOGY, vol. 29, no. 6, 1 November 2004 (2004-11-01), pages 658 - 663, XP055035428, ISSN: 0307-6938, DOI: 10.1111/j.1365-2230.2004.01638.x
TOMOMI NAKATANI ET AL: "CCR4+ memory CD4+ T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic dermatitis", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 107, no. 2, 1 February 2001 (2001-02-01), pages 353 - 358, XP055035429, ISSN: 0091-6749, DOI: 10.1067/mai.2001.112601
Y. TERAKI ET AL: "Homing receptor and chemokine receptor on intraepidermal T cells in psoriasis vulgaris", CLINICAL AND EXPERIMENTAL DERMATOLOGY, vol. 29, no. 6, 1 November 2004 (2004-11-01), pages 658 - 663, XP055035428, ISSN: 0307-6938, DOI: 10.1111/j.1365-2230.2004.01638.x
Attorney, Agent or Firm:
SPENCER, Matthew (70 Gray's Inn RoadLondon, Greater London WC1X 8BT, GB)
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