Title:
TREATING MUSCULOSKELETAL DISORDERS USING LP85 AND ANALOGS THEREOF
Document Type and Number:
WIPO Patent Application WO2001089450
Kind Code:
A3
Abstract:
The invention provides methods for treating or preventing osteoporosis, osteopenia, sarcopenia, arthritis, tissue atrophy, wound healing, traumatized connective tissues, grafted connective tissues, and/or transplanted organs in a mammal which comprise the administration of a therapeutically effective amount of a pharmaceutical composition comprising a LP85 polypeptide or LP85 analog.
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Inventors:
BEALS JOHN MICHAEL (US)
GONZALEZ-DEWHITT PATRICIA ANN (US)
HAMMOND LISA JANINE (US)
LU JIRONG (US)
NA SONGQING (US)
SU ERIC WEN (US)
WITCHER DERRICK RYAN (US)
WROBLEWSKI VICTOR JOHN (US)
GONZALEZ-DEWHITT PATRICIA ANN (US)
HAMMOND LISA JANINE (US)
LU JIRONG (US)
NA SONGQING (US)
SU ERIC WEN (US)
WITCHER DERRICK RYAN (US)
WROBLEWSKI VICTOR JOHN (US)
Application Number:
PCT/US2001/011755
Publication Date:
May 02, 2002
Filing Date:
May 08, 2001
Export Citation:
Assignee:
LILLY CO ELI (US)
BEALS JOHN MICHAEL (US)
GONZALEZ DEWHITT PATRICIA ANN (US)
HAMMOND LISA JANINE (US)
LU JIRONG (US)
NA SONGQING (US)
SU ERIC WEN (US)
WITCHER DERRICK RYAN (US)
WROBLEWSKI VICTOR JOHN (US)
BEALS JOHN MICHAEL (US)
GONZALEZ DEWHITT PATRICIA ANN (US)
HAMMOND LISA JANINE (US)
LU JIRONG (US)
NA SONGQING (US)
SU ERIC WEN (US)
WITCHER DERRICK RYAN (US)
WROBLEWSKI VICTOR JOHN (US)
International Classes:
A61P17/02; A61P19/02; A61P19/04; A61P19/10; A61P21/04; A61P25/00; C07K14/49; A61K38/00; (IPC1-7): C07K14/475; A61K38/18; C12N15/18; C12N15/62; C12Q1/68
Domestic Patent References:
| WO2000027879A1 | 2000-05-18 | |||
| WO2001025437A2 | 2001-04-12 | |||
| WO2000066736A1 | 2000-11-09 | |||
| WO2001057083A1 | 2001-08-09 | |||
| WO2001000878A2 | 2001-01-04 |
Other References:
MIDY V & PLOUËT J: "Vasculotropin/Vascular Endothelial Growth Factor induces differentiation in cultured osteoblasts", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 199, no. 1, 28 February 1994 (1994-02-28), pages 380 - 386, XP002148857, ISSN: 0006-291X
BERGSTEN E ET AL: "PDGF-D IS A SPECIFIC, PROTEASE-ACTIVATED LIGAND FOR THE PDGF BETA-RECEPTOR", NATURE CELL BIOLOGY, MACMILLAN PUBLISHERS, GB, vol. 3, 11 April 2001 (2001-04-11), pages 512 - 516, XP002941175, ISSN: 1465-7392
LAROCHELLE WILLIAM J ET AL: "PDGF-D, a new protease-activated growth factor.", NATURE CELL BIOLOGY, vol. 3, no. 5, May 2001 (2001-05-01), pages 517 - 521, XP001053430, ISSN: 1465-7392
BERGSTEN E ET AL: "PDGF-D IS A SPECIFIC, PROTEASE-ACTIVATED LIGAND FOR THE PDGF BETA-RECEPTOR", NATURE CELL BIOLOGY, MACMILLAN PUBLISHERS, GB, vol. 3, 11 April 2001 (2001-04-11), pages 512 - 516, XP002941175, ISSN: 1465-7392
LAROCHELLE WILLIAM J ET AL: "PDGF-D, a new protease-activated growth factor.", NATURE CELL BIOLOGY, vol. 3, no. 5, May 2001 (2001-05-01), pages 517 - 521, XP001053430, ISSN: 1465-7392
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