Title:
TREATMENT AGENT FOR URINARY INCONTINENCE COMPRISING PRE-DIFFERENTIATED AMNIOTIC FLUID STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2013/100215
Kind Code:
A1
Abstract:
The present invention relates to a cell treatment agent for muscular tissue regeneration comprising pre-differentiated amniotic fluid stem cells and, more particularly, to a cell treatment agent for sphincter urethrae regeneration comprising, as active ingredients, a mixture of muscle, nerve, and endothelium cells, wherein the three kinds of cells are pre-differentiated in vitro from amniotic fluid stem cells. Also, the present invention relates to a composition comprising pre-differentiated amniotic fluid stem cells for the prevention and treatment of urinary incontinence. The composition, according to the present invention, comprises pre-differentiated amniotic fluid stem cells and has an outstanding effect on the regeneration of muscular tissue, and can thus be effective as a treatment agent for urinary incontinence.
Inventors:
LIM JEONG OK (KR)
KWON TAE GYUN (KR)
CHUN SO YOUNG (KR)
YOO JAMES J (US)
KWON TAE GYUN (KR)
CHUN SO YOUNG (KR)
YOO JAMES J (US)
Application Number:
PCT/KR2011/010136
Publication Date:
July 04, 2013
Filing Date:
December 27, 2011
Export Citation:
Assignee:
KYUNGPOOK NAT UNIV HOSPITAL (KR)
LIM JEONG OK (KR)
KWON TAE GYUN (KR)
CHUN SO YOUNG (KR)
YOO JAMES J (US)
LIM JEONG OK (KR)
KWON TAE GYUN (KR)
CHUN SO YOUNG (KR)
YOO JAMES J (US)
International Classes:
A61K35/50; A61K35/12; A61P13/10; A61K35/30; A61K35/34; A61K35/44
Other References:
TAB GYUN KWON ET AL.: "Human amniotic fluid stem cell therapy for urethral sphincter regeneration", THE JOURNAL OF UROLOGY, vol. 185, no. 4, 15 May 2011 (2011-05-15), pages E73
PIETERNELLA S. IN'T ANKER ET AL.: "Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation", BLOOD, vol. 102, no. 4, 2003, pages 1548 - 1549, XP009085337, DOI: doi:10.1182/blood-2003-04-1291
KARL-DIETRICH SIEVERT ET AL.: "Tissue engineering for the lower urinary tract: a review of a state of the art approach", EUROPEAN UROLOGY, vol. 52, no. 6, 2007, pages 1580 - 1589
ANDREA STAACK ET AL.: "Stem cells for the treatment of urinary incontinence", CURR. UROL. REP., vol. 12, no. 1, February 2011 (2011-02-01), pages 41 - 46
PIETERNELLA S. IN'T ANKER ET AL.: "Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation", BLOOD, vol. 102, no. 4, 2003, pages 1548 - 1549, XP009085337, DOI: doi:10.1182/blood-2003-04-1291
KARL-DIETRICH SIEVERT ET AL.: "Tissue engineering for the lower urinary tract: a review of a state of the art approach", EUROPEAN UROLOGY, vol. 52, no. 6, 2007, pages 1580 - 1589
ANDREA STAACK ET AL.: "Stem cells for the treatment of urinary incontinence", CURR. UROL. REP., vol. 12, no. 1, February 2011 (2011-02-01), pages 41 - 46
Attorney, Agent or Firm:
KIM, SOON WOONG (KR)
κΉμμ (KR)
κΉμμ (KR)
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Claims: