Title:
TREATMENT FOR ALZHEIMER'S DISEASE AND RELATED CONDITIONS
Document Type and Number:
WIPO Patent Application WO2005058308
Kind Code:
A3
Abstract:
This invention provides the combination of a growth hormone secretagogue and a p38 kinase inhibitor for use in treatment or prevention of a disease associated with deposition of Abeta in the brain.
Inventors:
CASTRO PINEIRO JOSE LUIS (GB)
Application Number:
PCT/GB2004/005234
Publication Date:
September 15, 2005
Filing Date:
December 14, 2004
Export Citation:
Assignee:
MERCK SHARP & DOHME (GB)
CASTRO PINEIRO JOSE LUIS (GB)
CASTRO PINEIRO JOSE LUIS (GB)
International Classes:
A61K31/395; A61K31/44; A61K31/45; A61K31/47; A61K31/495; A61K31/50; A61K31/517; A61K31/519; A61K31/535; A61K31/55; A61K45/06; (IPC1-7): A61K31/395; A61K31/55; A61K31/535; A61K31/495; A61K31/50; A61K31/519; A61K31/517; A61K31/44; A61K31/47; A61K31/445; A61P25/28; A61K31/45
Domestic Patent References:
| WO2004087157A2 | 2004-10-14 |
Foreign References:
| US5767124A | 1998-06-16 | |||
| EP1258250A1 | 2002-11-20 |
Other References:
SMITH R G: "The aging process: where are the drug opportunities?", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 4, no. 4, August 2000 (2000-08-01), pages 371 - 376, XP002284307, ISSN: 1367-5931
DALRYMPLE S A: "P38 MITOGEN ACTIVATED PROTEIN KINASE AS A THERAPEUTIC TARGET FOR ALZHEIMER'S DISEASE", JOURNAL OF MOLECULAR NEUROSCIENCE, BIRKHAEUSER, CAMBRIDGE, MA, US, vol. 19, no. 3, December 2002 (2002-12-01), pages 295 - 299, XP009048755, ISSN: 0895-8696
ANKERSEN M ET AL: "Growth hormone secretagogues: recent advances and applications", DRUG DISCOVERY TODAY, ELSEVIER SCIENCE LTD, GB, vol. 4, no. 11, 1999, pages 497 - 506, XP002291825, ISSN: 1359-6446
MERRIAM. G.R. ET AL.: "Growth hormone-releasing hormone and growth hormone secretagogues in normal aging", ENDOCRINE, vol. 22, no. 1, October 2003 (2003-10-01), pages 41 - 48, XP009048783
DALRYMPLE S A: "P38 MITOGEN ACTIVATED PROTEIN KINASE AS A THERAPEUTIC TARGET FOR ALZHEIMER'S DISEASE", JOURNAL OF MOLECULAR NEUROSCIENCE, BIRKHAEUSER, CAMBRIDGE, MA, US, vol. 19, no. 3, December 2002 (2002-12-01), pages 295 - 299, XP009048755, ISSN: 0895-8696
ANKERSEN M ET AL: "Growth hormone secretagogues: recent advances and applications", DRUG DISCOVERY TODAY, ELSEVIER SCIENCE LTD, GB, vol. 4, no. 11, 1999, pages 497 - 506, XP002291825, ISSN: 1359-6446
MERRIAM. G.R. ET AL.: "Growth hormone-releasing hormone and growth hormone secretagogues in normal aging", ENDOCRINE, vol. 22, no. 1, October 2003 (2003-10-01), pages 41 - 48, XP009048783
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