Title:
TREATMENT OF CELIAC DISEASE
Document Type and Number:
WIPO Patent Application WO1999056698
Kind Code:
A3
Abstract:
The present invention relates to a method of treating celiac disease comprising interfering with the deamidation of at least one glutamine residue in a gliadin or glutenin molecule. This may be provided by prohibiting or interfering with the deamidation of at least one glutamine residue by derivation of at least one glutamine residue in a gliadin or glutenine molecule in wheat flour by a chemical or enzymatic deamidation of gluten followed by chemical or enzymatic derivation of the generated carboxyl group(s). In a further aspect, the invention relates to a method of interfering with the deamidation of at least one glutamine residue in a gliadin or glutenin molecule and thereby treating celiac disease, the method comprising administering, to a patient having or suspected of having celiac disease, at least one of the following substances: (a) a substance which is capable of increasing the pH in the gastroduodenal tract of a subject, e.g. an antacidum, an anticholinergic agent, H2-receptor antagonists or a proton pump inhibitor, (b) a substance which is capable of eliminating deamidating bacteria in the gastroduodenal tract of a subject, e.g. an antibiotic or antimicrobial agent, and/or (c) a substance which is capable of interfering with the effect of at least one deamidating enzyme in the gastroduodenal tract of a subject.
Inventors:
SJOESTROEM HANS (SE)
NOREN OVE (DK)
NOREN OVE (DK)
Application Number:
PCT/DK1999/000255
Publication Date:
December 29, 1999
Filing Date:
May 06, 1999
Export Citation:
Assignee:
UNIV KOEBENHAVN (DK)
SJOESTROEM HANS (SE)
NOREN OVE (DK)
SJOESTROEM HANS (SE)
NOREN OVE (DK)
International Classes:
A61K31/341; A61K31/352; A61K31/4164; A61K31/426; A61K31/439; A61K31/4439; A61K33/06; A61K33/08; A61K33/10; A61K33/12; (IPC1-7): A61K33/06; A61K31/34; A61K31/35; A61K31/415; A61K31/425; A61K31/435; A61K31/44; A61K33/08; A61K33/10; A61K33/12
Domestic Patent References:
| WO1998003872A2 | 1998-01-29 | |||
| WO1992018524A1 | 1992-10-29 |
Foreign References:
| DD262999A1 | 1988-12-21 | |||
| EP0444829A2 | 1991-09-04 | |||
| US4338334A | 1982-07-06 | |||
| EP0278174A2 | 1988-08-17 |
Other References:
BRUCE, S. E. ET AL: "Human jejunal transglutaminase: demonstration of activity, enzyme kinetics and substrate specificity with special relation to gliadin and celiac disease", CLIN. SCI. (1985), 68(5), 573-9 CODEN: CSCIAE;ISSN: 0143-5221, XP002085949
DATABASE WPI Section Ch Week 199113, Derwent World Patents Index; Class B06, AN 1991-092939, XP002118955
UNSWORTH J ET AL: "Flat small intestinal mucosa and autoantibodies against the gut epithelium.", JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, (1982) 1 (4) 503-13. JOURNAL CODE: JL6. ISSN: 0277-2116., United States, XP002085950
DE MAGALHAES A.F.N. ET AL: "[The use of antibiotics in digestive tract diseases]. USO DE ANTIBIOTICOS EM DOENCAS DO APARELHO DIGESTIVO.", REVISTA BRASILEIRA DE CLINICA E TERAPEUTICA, (1979) 8/11 (505-516). CODEN: RBCTAP, XP002118952
SOLLID L M ET AL: "Autoantibodies in coeliac disease: tissue transglutaminase --guilt by association?.", GUT, (1997 DEC) 41 (6) 851-2., XP002118953
UHLIG, H. ET AL: "Role of tissue transglutaminase in gliadin binding to reticular extracellular matrix and relation to coeliac disease autoantibodies", AUTOIMMUNITY (1998), 28(4), 185-195, XP002118954
MEHTA D.I. ET AL: "Chronic diarrhea: Causes, presentation, and management.", INDIAN JOURNAL OF PEDIATRICS, (1996) 63/4 (459-471). ISSN: 0019-5456 CODEN: IJPEA2, India, XP002085951
MOLBERG, OYBIND ET AL: "Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease", NAT. MED. (N. Y.) (1998), 4(6), 713-717 CODEN: NAMEFI;ISSN: 1078-8956, XP002085952
KASPER H ET AL: "[Therapy of diseases of the small intestine]. Die Therapie von Dunndarmerkrankungen.", MEDIZINISCHE WELT, (1969 DEC 20) 51 2777-9. JOURNAL CODE: MIM. ISSN: 0025-8512., GERMANY, WEST: Germany, Federal Republic of, XP002085953
JOURET A. ET AL: "[Digestive pathologies and intraepithelial lymphocytes]. PATHOLOGIE DIGESTIVE ET LYMPHOCYTES INTRA-EPITHELIAUX.", ACTA ENDOSCOPICA, (1995) 25/5 SUPPL. (563-569). ISSN: 0240-642X CODEN: AENDD5, France, XP002085954
FRIIS S U: "COELIAC DISEASE. PATHOGENESIS AND CLINICAL ASPECTS", APMIS, vol. 104, no. SUPPL. 61, 1 January 1996 (1996-01-01), pages 5 - 48, XP000605982, ISSN: 0903-4641
FREEMAN H.J.: "Ranitidine -associated interstitial nephritis in a patient with celiac sprue.", CAN. J. GASTROENTEROL., (1988) 2/1 (35-36). ISSN: 0835-7900 CODEN: CJGAEJ, Canada, XP002085955
GRAHAM D Y ET AL: "Mechanism of increase in steatorrhea with calcium and magnesium in exocrine pancreatic insufficiency: an animal model.", GASTROENTEROLOGY, (1982 SEP) 83 (3) 638-44. JOURNAL CODE: FH3. ISSN: 0016-5085., United States, XP002085956
GRAHAM D Y: "Pancreatic enzyme replacement: the effect of antacids or cimetidine.", DIGESTIVE DISEASES AND SCIENCES, (1982 JUN) 27 (6) 485-90. JOURNAL CODE: EAD. ISSN: 0163-2116., United States, XP002085957
DATABASE WPI Section Ch Week 199113, Derwent World Patents Index; Class B06, AN 1991-092939, XP002118955
UNSWORTH J ET AL: "Flat small intestinal mucosa and autoantibodies against the gut epithelium.", JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, (1982) 1 (4) 503-13. JOURNAL CODE: JL6. ISSN: 0277-2116., United States, XP002085950
DE MAGALHAES A.F.N. ET AL: "[The use of antibiotics in digestive tract diseases]. USO DE ANTIBIOTICOS EM DOENCAS DO APARELHO DIGESTIVO.", REVISTA BRASILEIRA DE CLINICA E TERAPEUTICA, (1979) 8/11 (505-516). CODEN: RBCTAP, XP002118952
SOLLID L M ET AL: "Autoantibodies in coeliac disease: tissue transglutaminase --guilt by association?.", GUT, (1997 DEC) 41 (6) 851-2., XP002118953
UHLIG, H. ET AL: "Role of tissue transglutaminase in gliadin binding to reticular extracellular matrix and relation to coeliac disease autoantibodies", AUTOIMMUNITY (1998), 28(4), 185-195, XP002118954
MEHTA D.I. ET AL: "Chronic diarrhea: Causes, presentation, and management.", INDIAN JOURNAL OF PEDIATRICS, (1996) 63/4 (459-471). ISSN: 0019-5456 CODEN: IJPEA2, India, XP002085951
MOLBERG, OYBIND ET AL: "Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease", NAT. MED. (N. Y.) (1998), 4(6), 713-717 CODEN: NAMEFI;ISSN: 1078-8956, XP002085952
KASPER H ET AL: "[Therapy of diseases of the small intestine]. Die Therapie von Dunndarmerkrankungen.", MEDIZINISCHE WELT, (1969 DEC 20) 51 2777-9. JOURNAL CODE: MIM. ISSN: 0025-8512., GERMANY, WEST: Germany, Federal Republic of, XP002085953
JOURET A. ET AL: "[Digestive pathologies and intraepithelial lymphocytes]. PATHOLOGIE DIGESTIVE ET LYMPHOCYTES INTRA-EPITHELIAUX.", ACTA ENDOSCOPICA, (1995) 25/5 SUPPL. (563-569). ISSN: 0240-642X CODEN: AENDD5, France, XP002085954
FRIIS S U: "COELIAC DISEASE. PATHOGENESIS AND CLINICAL ASPECTS", APMIS, vol. 104, no. SUPPL. 61, 1 January 1996 (1996-01-01), pages 5 - 48, XP000605982, ISSN: 0903-4641
FREEMAN H.J.: "Ranitidine -associated interstitial nephritis in a patient with celiac sprue.", CAN. J. GASTROENTEROL., (1988) 2/1 (35-36). ISSN: 0835-7900 CODEN: CJGAEJ, Canada, XP002085955
GRAHAM D Y ET AL: "Mechanism of increase in steatorrhea with calcium and magnesium in exocrine pancreatic insufficiency: an animal model.", GASTROENTEROLOGY, (1982 SEP) 83 (3) 638-44. JOURNAL CODE: FH3. ISSN: 0016-5085., United States, XP002085956
GRAHAM D Y: "Pancreatic enzyme replacement: the effect of antacids or cimetidine.", DIGESTIVE DISEASES AND SCIENCES, (1982 JUN) 27 (6) 485-90. JOURNAL CODE: EAD. ISSN: 0163-2116., United States, XP002085957
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