Title:
TREATMENT DRUG FOR TREATING DISEASE INVOLVING eIF2B
Document Type and Number:
WIPO Patent Application WO/2022/244865
Kind Code:
A1
Abstract:
Provided is a treatment drug that controls the action of eIF2B and thereby inhibits the integrated stress response pathway, making it possible to obtain a treatment drug that can be used to treat and/or prevent diseases involving the integrated stress response pathway such as neurodegenerative diseases. The present invention is a treatment agent for treating diseases involving eIF2B, the treatment agent containing a compound including the SFSV NSs protein or at least a part of the SFSV NSs protein, or a compound that induces expression of at least a part of the SFSV NSs protein.
Inventors:
ITO TAKUHIRO (JP)
KASHIWAGI KAZUHIRO (JP)
IWASAKI SHINTARO (JP)
SHICHINO YUICHI (JP)
IKEUCHI YOSHIHO (JP)
OSAKI TATSUYA (JP)
KASHIWAGI KAZUHIRO (JP)
IWASAKI SHINTARO (JP)
SHICHINO YUICHI (JP)
IKEUCHI YOSHIHO (JP)
OSAKI TATSUYA (JP)
Application Number:
PCT/JP2022/020964
Publication Date:
November 24, 2022
Filing Date:
May 20, 2022
Export Citation:
Assignee:
RIKEN (JP)
UNIV TOKYO (JP)
UNIV TOKYO (JP)
International Classes:
A61K38/16; A61K48/00; A61P25/00
Other References:
WUERTH JENNIFER DEBORAH, HABJAN MATTHIAS, KAINULAINEN MARKUS, BERISHA BESIM, BERTHELOOT DAMIEN, SUPERTI-FURGA GIULIO, PICHLMAIR AN: "eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition", MBIO, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 11, no. 4, 25 August 2020 (2020-08-25), US , XP093006187, ISSN: 2161-2129, DOI: 10.1128/mBio.00976-20
MARINTCHEV ASSEN, ITO TAKUHIRO: "eIF2B and the Integrated Stress Response: A Structural and Mechanistic View", BIOCHEMISTRY, vol. 59, no. 13, 7 April 2020 (2020-04-07), pages 1299 - 1308, XP093006189, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.0c00132
KASHIWAGI KAZUHIRO, SHICHINO YUICHI, OSAKI TATSUYA, SAKAMOTO AYAKO, NISHIMOTO MADOKA, TAKAHASHI MARI, MITO MARI, WEBER FRIEDEMANN,: "eIF2B-capturing viral protein NSs suppresses the integrated stress response", NATURE COMMUNICATIONS, vol. 12, no. 1, XP093006190, DOI: 10.1038/s41467-021-27337-x
MARINTCHEV ASSEN, ITO TAKUHIRO: "eIF2B and the Integrated Stress Response: A Structural and Mechanistic View", BIOCHEMISTRY, vol. 59, no. 13, 7 April 2020 (2020-04-07), pages 1299 - 1308, XP093006189, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.0c00132
KASHIWAGI KAZUHIRO, SHICHINO YUICHI, OSAKI TATSUYA, SAKAMOTO AYAKO, NISHIMOTO MADOKA, TAKAHASHI MARI, MITO MARI, WEBER FRIEDEMANN,: "eIF2B-capturing viral protein NSs suppresses the integrated stress response", NATURE COMMUNICATIONS, vol. 12, no. 1, XP093006190, DOI: 10.1038/s41467-021-27337-x
Attorney, Agent or Firm:
MATSUNUMA Yasushi et al. (JP)
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