Title:
TREATMENT OF EBV AND KHSV INFECTION AND ASSOCIATED ABNORMAL CELLULAR PROLIFERATION
Document Type and Number:
WIPO Patent Application WO2003053360
Kind Code:
A3
Abstract:
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an effective amount of a 5-substituted uracil nucleoside or its pharmaceutically acceptable salt or prodrug, optionally in a pharmaceutically acceptable diluent or excipient.
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Inventors:
SCHINAZI RAYMOND F (US)
SHI JUNXING (US)
FINGEROTH JOYCE D (US)
GUSTAFSON ERIK (US)
SHI JUNXING (US)
FINGEROTH JOYCE D (US)
GUSTAFSON ERIK (US)
Application Number:
PCT/US2002/040853
Publication Date:
July 07, 2005
Filing Date:
December 19, 2002
Export Citation:
Assignee:
PHARMASSETT LTD (BB)
BETH ISRAEL HOSPITAL (US)
UNIV EMORY (US)
SCHINAZI RAYMOND F (US)
SHI JUNXING (US)
FINGEROTH JOYCE D (US)
GUSTAFSON ERIK (US)
BETH ISRAEL HOSPITAL (US)
UNIV EMORY (US)
SCHINAZI RAYMOND F (US)
SHI JUNXING (US)
FINGEROTH JOYCE D (US)
GUSTAFSON ERIK (US)
International Classes:
A61K31/513; A61K31/58; C07D239/54; A61K31/7072; A61K38/16; A61K45/06; A61K48/00; A61P31/12; A61P35/00; A61P43/00; C07D405/04; C07D405/14; C07D409/14; C07H19/067; C07H19/073; C07J43/00; (IPC1-7): A61K31/70; C07H19/06
Foreign References:
| US4681933A | 1987-07-21 | |||
| US4841039A | 1989-06-20 | |||
| US4542210A | 1985-09-17 | |||
| US4957924A | 1990-09-18 | |||
| US5356882A | 1994-10-18 | |||
| US5565438A | 1996-10-15 | |||
| US5587362A | 1996-12-24 | |||
| US6022876A | 2000-02-08 |
Other References:
WATANABE K.A. ET AL: "Synthesis of Antiviral Nucleosides: 5-Alkenyl-1-(2-deoxy-2-fluoro-B-D-arabinofuranosyl)uracils.", J. MED. CHEM., vol. 27, 1984, pages 91 - 94, XP002987411
YAO G.Q. ET AL: "Inhibition of Epstein-Barr Virus Replication by a NOvel L-Nucleoside, 2'Fluoro-5-methyl-B-L-arabinofuranosyluracil.", BIOCHEMICAL PHARMACOLOGY, vol. 51, 1996, pages 941 - 947, XP002987412
PAGANO J.: "Epstein-Barr Virus: Therapy of Active and Latent Infection Antiviral Chemotherapy", 1995, XP008047450
RAHIM ET AL: "Synthesis and Anti-Herpes Virus Activity of 2'-Deoxy-4'-Thiopyrimidine Nucleosides.", J.MED. CHEM., vol. 39, 1996, pages 789 - 795, XP002987413
YAO G.Q. ET AL: "Inhibition of Epstein-Barr Virus Replication by a NOvel L-Nucleoside, 2'Fluoro-5-methyl-B-L-arabinofuranosyluracil.", BIOCHEMICAL PHARMACOLOGY, vol. 51, 1996, pages 941 - 947, XP002987412
PAGANO J.: "Epstein-Barr Virus: Therapy of Active and Latent Infection Antiviral Chemotherapy", 1995, XP008047450
RAHIM ET AL: "Synthesis and Anti-Herpes Virus Activity of 2'-Deoxy-4'-Thiopyrimidine Nucleosides.", J.MED. CHEM., vol. 39, 1996, pages 789 - 795, XP002987413
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