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Title:
TREATMENT OF HEMATOLOGIC CANCER WITH PD-1/CD3 DUAL SPECIFICITY PROTEIN
Document Type and Number:
WIPO Patent Application WO/2021/006199
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel drug for preventing hematologic cancer, suppressing the progression of a symptom of hematologic cancer, suppressing the recurrence of hematologic cancer or treating hematologic cancer.　The present inventors have studied extensively and intensively. As a result, the present inventors have focused attention on a dual specificity protein having a first arm capable of binding specifically to PD-1 and a second arm capable of binding specifically to CD3 (preferably a PD-1/CD3 dual specificity antibody or an antibody fragment thereof) as a substance that can solve the problem, and have found that the dual specificity protein is useful for the prevention of hematologic cancer, the suppression of the progression of a symptom of hematologic cancer, the suppression of the recurrence of hematologic cancer or the treatment of hematologic cancer.

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Inventors:
SHIBAYAMA SHIRO (JP)
SHIMBO TAKUYA (JP)
Application Number:
PCT/JP2020/026149
Publication Date:
January 14, 2021
Filing Date:
July 03, 2020
Export Citation:
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Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
A61K39/395; A61K45/00; A61P35/00; A61P35/02; C07K16/28; C07K16/30; C07K16/46; C12N15/13; C12N15/62
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Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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