Title:
TREATMENT OF HER3 MUTANT CANCER BY ADMINISTRATION OF ANTI-HER3 ANTIBODY-DRUG CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2020/059772
Kind Code:
A1
Abstract:
Provided are: a therapeutic agent for HER3 mutant cancer, the therapeutic agent containing an anti-HER3 antibody-drug conjugate as an active ingredient; and/or a cancer treatment method characterized in that said anti-HER3 antibody-drug conjugate is administered to a patient confirmed to have HER3 mutant cancer.
Inventors:
KOYAMA KUMIKO (JP)
SHIOSE YOSHINOBU (JP)
UENO SUGURU (JP)
SHIOSE YOSHINOBU (JP)
UENO SUGURU (JP)
Application Number:
PCT/JP2019/036668
Publication Date:
March 26, 2020
Filing Date:
September 19, 2019
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
A61K47/68; A61K31/437; A61K39/395; A61K47/65; A61P1/00; A61P11/00; A61P15/00; A61P17/00; A61P25/00; A61P35/00
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NATURE, vol. 455, no. 7216, 23 October 2008 (2008-10-23), pages 1069 - 75
NAT GENET, vol. 46, no. 6, June 2014 (2014-06-01), pages 573 - 82
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NAT GENET, vol. 46, no. 10, October 2014 (2014-10-01), pages 1097 - 102
CELL REP., vol. 15, no. 4, 26 April 2016 (2016-04-26), pages 857 - 865
INT J CANCER, vol. 119, no. 12, 15 December 2006 (2006-12-15), pages 2986 - 7
NAT GENET, vol. 46, no. 12, December 2014 (2014-12-01), pages 1264 - 6
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CLIN CANCER RES, vol. 22, no. 7, 1 April 2016 (2016-04-01), pages 1583 - 91
CLIN CANCER RES, vol. 22, no. 24, 15 December 2016 (2016-12-15), pages 6061 - 6068
CANCER RES, vol. 76, no. 20, 15 October 2016 (2016-10-15), pages 5954 - 5961
PLOS MED, vol. 13, no. 12, 27 December 2016 (2016-12-27), pages e1002201
"HER2 Test Guide", BREAST CANCER
OGITANI Y. ET AL., CLINICAL CANCER RESEARCH, vol. 22, no. 20, 29 March 2016 (2016-03-29), pages 5097 - 5108
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
"Monoclonal Antibodies", 1980, PLENUM PRESS, pages: 365 - 367
PROC. NATL. ACAD. SCI. U.S.A., vol. 81, 1984, pages 6851 - 6855
NATURE, vol. 321, 1986, pages 522 - 525
TOMIZUKA, K. ET AL., NATURE GENETICS, vol. 16, 1997, pages 133 - 143
KUROIWA, Y., NUCL. ACIDS RES., vol. 26, 1998, pages 3447 - 3448
YOSHIDA, H.: "Animal Cell Technology: Basic and Applied Aspects", vol. 10, 1999, KLUWER ACADEMIC PUBLISHERS, pages: 69 - 73
TOMIZUKA, K., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 722 - 727
WORMSTONE, I. M., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 43, no. 7, 2002, pages 2301 - 2308
CARMEN, S., BRIEFINGS IN FUNCTIONAL GENOMICS AND PROTEOMICS, vol. 1, no. 2, 2002, pages 189 - 203
SIRIWARDENA, D., OPHTHALMOLOGY, vol. 109, no. 3, 2002, pages 427 - 431
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
ANALYTICAL BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
HERMANSON, G.T: "Bioconjugate Techniques", ACADEMIC PRESS, pages: 56 - 136,456-493
See also references of EP 3854418A4
ALIMANDI ET AL., ONCOGENE, vol. 10, 1995, pages 1813 - 1821
DEFAZIO ET AL., INT. J. CANCER, vol. 87, 2000, pages 487 - 498
NAIDU ET AL., BR. J. CANCER, vol. 78, 1998, pages 1385 - 1390
GREENMAN ET AL., NATURE, vol. 446, 2007, pages 153 - 41
JEONG ET AL., INT. J. CANCER, vol. 119, 2006, pages 2986 - 7
DING ET AL., NATURE, vol. 455, 2008, pages 1069 - 75
KAN ET AL., NATURE, vol. 466, 2010, pages 869 - 73
WANG ET AL., NAT. GENET., vol. 43, 2011, pages 1219 - 23
STRANSKY ET AL., SCIENCE, vol. 333, 2011, pages 1157 - 60
JAISWAL ET AL., CANCER CELL, vol. 23, 2013, pages 603 - 17
HYMAN ET AL., CANCER RES, 2017
MISHRA ET AL., ONCOTARGET, vol. 69, 2017, pages 114371 - 114392
MISHRA ET AL., ONCOTARGET, vol. 45, 2018, pages 27773 - 27788
DUCRY ET AL., BIOCONJUGATE CHEM, vol. 21, 2010, pages 5 - 13
ALLEY ET AL., CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 14, 2010, pages 529 - 537
DAMLE, EXPERT OPIN. BIOL. THER., vol. 4, 2004, pages 1445 - 1452
SENTER ET AL., NATURE BIOTECHNOLOGY, vol. 30, 2012, pages 631 - 637
HOWARD ET AL., J CLIN ONCOL, vol. 29, 2011, pages 398 - 405
CANCER CELL, vol. 23, no. 5, 13 May 2013 (2013-05-13), pages 603 - 17
NAT GENET, vol. 46, no. 8, August 2014 (2014-08-01), pages 872 - 6
CANCER RES, vol. 74, no. 21, 1 November 2014 (2014-11-01), pages 6071 - 81
CANCER, vol. 122, no. 17, 1 September 2016 (2016-09-01), pages 2654 - 62
NAT MED, vol. 23, no. 6, June 2017 (2017-06-01), pages 703 - 713
NATURE, vol. 554, no. 7691, 8 February 2018 (2018-02-08), pages 189 - 194
HUM MUTAT, vol. 29, no. 3, March 2008 (2008-03-01), pages 441 - 50
GENOME BIOL, vol. 15, no. 4, 1 April 2014 (2014-04-01), pages R55
CANCER RES., vol. 74, no. 12, 15 June 2014 (2014-06-15), pages 3238 - 47
ANN ONCOL, vol. 27, no. 1, January 2016 (2016-01-01), pages 127 - 33
NAT GENET, vol. 45, no. 5, May 2013 (2013-05-01), pages 478 - 86
CANCER CELL, vol. 29, no. 2, 8 February 2016 (2016-02-08), pages 229 - 40
CELL REP, vol. 15, no. 4, 26 April 2016 (2016-04-26), pages 857 - 865
GASTROENTEROLOGY, vol. 146, no. 2, February 2014 (2014-02-01), pages 530 - 38
NATURE, vol. 455, no. 7216, 23 October 2008 (2008-10-23), pages 1069 - 75
NAT GENET, vol. 46, no. 6, June 2014 (2014-06-01), pages 573 - 82
ANN ONCOL, vol. 26, no. 8, August 2015 (2015-08-01), pages 1704 - 9
PLOS ONE, vol. 9, no. 3, 5 March 2014 (2014-03-05), pages e90459
NAT GENET, vol. 46, no. 10, October 2014 (2014-10-01), pages 1097 - 102
CELL REP., vol. 15, no. 4, 26 April 2016 (2016-04-26), pages 857 - 865
INT J CANCER, vol. 119, no. 12, 15 December 2006 (2006-12-15), pages 2986 - 7
NAT GENET, vol. 46, no. 12, December 2014 (2014-12-01), pages 1264 - 6
NAT GENET, vol. 43, no. 12, 30 October 2011 (2011-10-30), pages 1219 - 23
CLIN CANCER RES, vol. 22, no. 7, 1 April 2016 (2016-04-01), pages 1583 - 91
CLIN CANCER RES, vol. 22, no. 24, 15 December 2016 (2016-12-15), pages 6061 - 6068
CANCER RES, vol. 76, no. 20, 15 October 2016 (2016-10-15), pages 5954 - 5961
PLOS MED, vol. 13, no. 12, 27 December 2016 (2016-12-27), pages e1002201
"HER2 Test Guide", BREAST CANCER
OGITANI Y. ET AL., CLINICAL CANCER RESEARCH, vol. 22, no. 20, 29 March 2016 (2016-03-29), pages 5097 - 5108
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
"Monoclonal Antibodies", 1980, PLENUM PRESS, pages: 365 - 367
PROC. NATL. ACAD. SCI. U.S.A., vol. 81, 1984, pages 6851 - 6855
NATURE, vol. 321, 1986, pages 522 - 525
TOMIZUKA, K. ET AL., NATURE GENETICS, vol. 16, 1997, pages 133 - 143
KUROIWA, Y., NUCL. ACIDS RES., vol. 26, 1998, pages 3447 - 3448
YOSHIDA, H.: "Animal Cell Technology: Basic and Applied Aspects", vol. 10, 1999, KLUWER ACADEMIC PUBLISHERS, pages: 69 - 73
TOMIZUKA, K., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 722 - 727
WORMSTONE, I. M., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 43, no. 7, 2002, pages 2301 - 2308
CARMEN, S., BRIEFINGS IN FUNCTIONAL GENOMICS AND PROTEOMICS, vol. 1, no. 2, 2002, pages 189 - 203
SIRIWARDENA, D., OPHTHALMOLOGY, vol. 109, no. 3, 2002, pages 427 - 431
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
ANALYTICAL BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
HERMANSON, G.T: "Bioconjugate Techniques", ACADEMIC PRESS, pages: 56 - 136,456-493
See also references of EP 3854418A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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