Title:
TREATMENT OF POSTERIOR CAPSULE OPACIFICATION
Document Type and Number:
WIPO Patent Application WO2002047728
Kind Code:
A3
Abstract:
Posterior capsular opacification is inhibited by administration of polymer, having immobilised on the surface, a ligand for a death receptor, preferably joined by a spacer into the lens capsule following cataract surgery. The ligand is preferably Fas ligand. A spacer is preferably polyethylene glycol. The polymer preferably constitutes an intraocular lens.
Inventors:
ALLAN BRUCE DUNCAN SAMUEL (GB)
Application Number:
PCT/GB2001/005465
Publication Date:
December 05, 2002
Filing Date:
December 11, 2001
Export Citation:
Assignee:
MOORFIELDS EYE HOSP NHS TRUST (GB)
INST OF OPHTHALMOLOGY UNIVERSI (GB)
ALLAN BRUCE DUNCAN SAMUEL (GB)
INST OF OPHTHALMOLOGY UNIVERSI (GB)
ALLAN BRUCE DUNCAN SAMUEL (GB)
International Classes:
A61K47/30; A61K38/00; A61K39/395; A61K45/00; A61K47/34; A61K47/48; A61L15/44; A61L27/00; A61L27/28; A61L27/54; A61P17/02; A61P27/12; A61P35/00; A61P41/00; A61P43/00; C07K16/28; (IPC1-7): A61K39/395; A61L27/28; A61L27/54; A61P27/12; C07K16/28
Foreign References:
| EP0716095A1 | 1996-06-12 | |||
| EP0299467A1 | 1989-01-18 |
Other References:
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NISHI, OKIHIRO ET AL: "Apoptosis through the Fas-Fas ligand pathway in lens epithelial cells of human cataracts", XP002166586, retrieved from STN Database accession no. 129:329317 HCA
JORDAN JF ET AL.: "The death-receptors TRAMP and TRAIL are present in human Lens Epithelial Cells", 98TH ANNUAL MEETING DOG 2000, - 23 September 2000 (2000-09-23), XP002166584, Retrieved from the Internet [retrieved on 20010503]
DUNCAN G ET AL: "THAPSIGARGIN-COATED INTRAOCULAR LENSES INHIBIT HUMAN LENS CELL GROWTH.", NATURE MEDICINE, vol. 3, no. 9, 1997, pages 1026 - 1028, XP002166585, ISSN: 1078-8956
JORDAN JF ET AL.: "The death-receptors TRAMP and TRAIL are present in human Lens Epithelial Cells", 98TH ANNUAL MEETING DOG 2000, - 23 September 2000 (2000-09-23), XP002166584, Retrieved from the Internet
DUNCAN G ET AL: "THAPSIGARGIN-COATED INTRAOCULAR LENSES INHIBIT HUMAN LENS CELL GROWTH.", NATURE MEDICINE, vol. 3, no. 9, 1997, pages 1026 - 1028, XP002166585, ISSN: 1078-8956
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