Title:
TREATMENT OF PREMENSTRUAL SYNDROME AND MENOPAUSE
Document Type and Number:
WIPO Patent Application WO2001008637
Kind Code:
A3
Abstract:
A method of treating premenstrual syndrome and menopausal symptoms in a patient, the method comprising: administering to the patient an 1H-indole-3-methanol compound e.g., 1H-indole-3-methanol; ascorbigen) in a medically acceptable manner in a pharmaceutically effective amount. It has been found that the administration of such indoles, particularly, 1H-indole-3-methanol, greatly relieves the symptoms of PMS. Patients with PMS have reported decreased menstrual cramping, decreased menstrual flow, shorter duration of menses, decreased fatigue, less frequent headaches, improved mood, and decreased bloating resulting from the oral administration each day or during specific portions of the menstrual cycle of pharmaceutically effective amounts of dietary indoles derived from 1H indole-3-methanol. It has also been found that the administration of such indoles, particularly, 1H-indole-3-methanol, greatly relieves the symptoms of menopause.
Inventors:
ELLENBERGER SUZANNE R
ELLENBERGER WILLIAM P
ANDRUS G MERRILL
ELLENBERGER WILLIAM P
ANDRUS G MERRILL
Application Number:
PCT/US2000/040521
Publication Date:
September 27, 2001
Filing Date:
August 01, 2000
Export Citation:
Assignee:
DESIGNED NUTRITIONAL PRODUCTS (US)
International Classes:
A61K31/4035; A61K31/407; A61K31/7056; (IPC1-7): A61K31/40; A61K31/405
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, (COLUMBUS, OHIO, USA); JELLINCK ET AL.: "Influence of indole-3-carbinol on the hepatic microsomal formation catechol estrogens", XP002939298, Database accession no. 115:270105
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