Title:
TREATMENT AND PREVENTION OF A NEURODEGENERATIVE DISORDER
Document Type and Number:
WIPO Patent Application WO/2021/089768
Kind Code:
A3
Abstract:
The present invention relates to a compound of formula (I): for use in the treatment or prevention of a neurodegenerative disorder.
Inventors:
COOPER MATTHEW (GB)
O'NEILL LUKE (IE)
O'NEILL LUKE (IE)
Application Number:
PCT/EP2020/081263
Publication Date:
June 24, 2021
Filing Date:
November 06, 2020
Export Citation:
Assignee:
INFLAZOME LTD (IE)
International Classes:
A61K31/415; A61P25/16; A61P25/28
Domestic Patent References:
| WO2016131098A1 | 2016-08-25 | |||
| WO2019206871A1 | 2019-10-31 |
Other References:
RICHARD GORDON ET AL: "Inflammasome inhibition prevents alpha-synuclein pathology and dopaminergic neurodegeneration in mice", SCIENCE TRANSLATIONAL MEDICINE, 1 October 2018 (2018-10-01), pages 1 - 12, XP055769561, Retrieved from the Internet [retrieved on 20210127]
DEMPSEY C ET AL: "Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-[beta] and cognitive function in APP/PS1 mice", BRAIN, BEHAVIOR AND IMMUNITY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 61, 18 December 2016 (2016-12-18), pages 306 - 316, XP029920335, ISSN: 0889-1591, DOI: 10.1016/J.BBI.2016.12.014
YOUSHENG MO ET AL: "Bushen-Yizhi Formula Alleviates Neuroinflammation via Inhibiting NLRP3 Inflammasome Activation in a Mouse Model of Parkinson's Disease", EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 2018, 26 August 2018 (2018-08-26), US, pages 1 - 12, XP055769517, ISSN: 1741-427X, DOI: 10.1155/2018/3571604
ZHIJUAN MAO ET AL: "The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson's Disease in Rats", NEUROCHEMICAL RESEARCH., vol. 42, no. 4, 1 April 2017 (2017-04-01), US, pages 1104 - 1115, XP055769514, ISSN: 0364-3190, DOI: 10.1007/s11064-017-2185-0
DEMPSEY C ET AL: "Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-[beta] and cognitive function in APP/PS1 mice", BRAIN, BEHAVIOR AND IMMUNITY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 61, 18 December 2016 (2016-12-18), pages 306 - 316, XP029920335, ISSN: 0889-1591, DOI: 10.1016/J.BBI.2016.12.014
YOUSHENG MO ET AL: "Bushen-Yizhi Formula Alleviates Neuroinflammation via Inhibiting NLRP3 Inflammasome Activation in a Mouse Model of Parkinson's Disease", EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 2018, 26 August 2018 (2018-08-26), US, pages 1 - 12, XP055769517, ISSN: 1741-427X, DOI: 10.1155/2018/3571604
ZHIJUAN MAO ET AL: "The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson's Disease in Rats", NEUROCHEMICAL RESEARCH., vol. 42, no. 4, 1 April 2017 (2017-04-01), US, pages 1104 - 1115, XP055769514, ISSN: 0364-3190, DOI: 10.1007/s11064-017-2185-0
Attorney, Agent or Firm:
JOHNSON, Stephen et al. (GB)
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