Title:
TREATMENT OF PULMONARY AND OTHER CONDITIONS
Document Type and Number:
WIPO Patent Application WO/2014/183068
Kind Code:
A3
Abstract:
Disclosed is a compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of X1 – L – X2 wherein L is a linking moiety comprising an enone; and X1 and X2 are each independently an optionally-substituted N-heterocycle. Also disclosed are method for treating pulmonary conditions and other organ or system conditions with the compounds.
Inventors:
REDDY RAJU (US)
Application Number:
PCT/US2014/037548
Publication Date:
January 08, 2015
Filing Date:
May 09, 2014
Export Citation:
Assignee:
UNIV PITTSBURGH (US)
US DEPT VETERANS AFFAIRS (US)
US DEPT VETERANS AFFAIRS (US)
International Classes:
C07D403/06; A61K31/497; A61K31/506; A61P11/00; A61P11/06; A61P11/12; A61P35/00; C07D403/08
Domestic Patent References:
| WO2011033115A2 | 2011-03-24 | |||
| WO2010059245A2 | 2010-05-27 |
Foreign References:
| CN103086958A | 2013-05-08 | |||
| CN101475532A | 2009-07-08 | |||
| JPS63139339A | 1988-06-11 |
Other References:
ASHOK, D. ET AL.: "Microwave-assisted solvent-free synthesis of (2E,6E)-2,6-bis[(3- aryl)-1-phenyl-1H-pyrazol-4-ylmethylene]cycloalkanones''.", INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 19, no. 4, 2010, pages 313 - 316, XP008182581
WANG, ZHENNING ET AL.: "Synthesis and biological activity of 1,5-bis(substituted pyrazol-4-yl)-1,4-pentadien-3-one derivatives''.", YOUJI HUAXUE, vol. 29, no. 9, 2009, pages 1412 - 1418, XP008182578
WADA, TATSUO ET AL.: "Novel molecules for photorefractive application''.", MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY, SECTION A: MOLECULAR CRYSTALS AND LIQUID CRYSTALS, vol. 280, 1996, pages 71 - 78, XP009136831
HUNG, WEI JING ET AL.: "The reaction of 4-formylsydnone and methyl ketones''.", JOURNAL OF THE CHINESE CHEMICAL SOCIETY (TAIPEI, TAIWAN, vol. 40, no. 4, 1993, pages 385 - 91, XP055143377
EBERSBERG, J. ET AL.: "Heterocycle-substituted 3-pentadienones''.", NATURWISSENSCHAFTEN, vol. 52, no. 18, 1965, pages 514, XP008182585
FRESENIUS, PH.: "The reaction between barbituric acid and hydroxymethyl compounds. II.", ARZNEIMITTEL-FORSCHUNG, vol. 2, 1952, pages 28 - 30, XP008182580
POTAPOV A.S. ET AL.: "Sintez formilnykh proizvodnykh 1-ethylpirazola, bis-(3,5- dimethyl-1-pirazolyl)metana i azometinov na ikh osnove.", JOURNAL ORGANICHESKOI KHIMII, vol. 42, no. 4, 2006, pages 569 - 573, XP008182582
WANG, ZHENNING ET AL.: "Synthesis and biological activity of 1,5-bis(substituted pyrazol-4-yl)-1,4-pentadien-3-one derivatives''.", YOUJI HUAXUE, vol. 29, no. 9, 2009, pages 1412 - 1418, XP008182578
WADA, TATSUO ET AL.: "Novel molecules for photorefractive application''.", MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY, SECTION A: MOLECULAR CRYSTALS AND LIQUID CRYSTALS, vol. 280, 1996, pages 71 - 78, XP009136831
HUNG, WEI JING ET AL.: "The reaction of 4-formylsydnone and methyl ketones''.", JOURNAL OF THE CHINESE CHEMICAL SOCIETY (TAIPEI, TAIWAN, vol. 40, no. 4, 1993, pages 385 - 91, XP055143377
EBERSBERG, J. ET AL.: "Heterocycle-substituted 3-pentadienones''.", NATURWISSENSCHAFTEN, vol. 52, no. 18, 1965, pages 514, XP008182585
FRESENIUS, PH.: "The reaction between barbituric acid and hydroxymethyl compounds. II.", ARZNEIMITTEL-FORSCHUNG, vol. 2, 1952, pages 28 - 30, XP008182580
POTAPOV A.S. ET AL.: "Sintez formilnykh proizvodnykh 1-ethylpirazola, bis-(3,5- dimethyl-1-pirazolyl)metana i azometinov na ikh osnove.", JOURNAL ORGANICHESKOI KHIMII, vol. 42, no. 4, 2006, pages 569 - 573, XP008182582
Attorney, Agent or Firm:
RUPERT, Wayne (LLPOne World Trade Center, Suite 1600,121 SW Salmon Stree, Portland OR, US)
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