Title:
TRIAZINE DERIVATIVE HAVING VIRUS PROPAGATION INHIBITORY EFFECT, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2022/138988
Kind Code:
A1
Abstract:
The present invention provides a compound exhibiting a coronavirus 3CL protease inhibitory effect and pharmaceutically acceptable salts thereof, and a pharmaceutical composition containing the same. Further provided are crystals that are useful as a drug substance, and a pharmaceutical composition containing the same. The compound represented by formula (1) or pharmaceutically acceptable salts thereof.
Inventors:
TACHIBANA YUKI (JP)
UEHARA SHOTA (JP)
UNOH YUTO (JP)
NAKAHARA KENJI (JP)
TAODA YOSHIYUKI (JP)
YAMATSU YUKIKO (JP)
ANDO SHIGERU (JP)
SASAKI MICHIHITO (JP)
UEHARA SHOTA (JP)
UNOH YUTO (JP)
NAKAHARA KENJI (JP)
TAODA YOSHIYUKI (JP)
YAMATSU YUKIKO (JP)
ANDO SHIGERU (JP)
SASAKI MICHIHITO (JP)
Application Number:
PCT/JP2022/006496
Publication Date:
June 30, 2022
Filing Date:
February 17, 2022
Export Citation:
Assignee:
SHIONOGI & CO (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C07D403/14; A61K31/53; A61P31/14; A61P43/00
Domestic Patent References:
WO2012020749A1 | 2012-02-16 | |||
WO2010092966A1 | 2010-08-19 |
Other References:
OLUBIYI OLUJIDE O., OLAGUNJU MARYAM, KEUTMANN MONIKA, LOSCHWITZ JENNIFER, STRODEL BIRGIT: "High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2", MOLECULES, vol. 25, no. 14, pages 3193, XP055944494, DOI: 10.3390/molecules25143193
AKAJI KENICHI, KONNO HIROYUKI: "Design and Evaluation of Anti-SARS-Coronavirus Agents Based on Molecular Interactions with the Viral Protease", MOLECULES, vol. 25, no. 17, pages 3920, XP055826867, DOI: 10.3390/molecules25173920
LIU YUZHI; LIANG CHENGYUAN; XIN LIANG; REN XIAODONG; TIAN LEI; JU XINGKE; LI HAN; WANG YONGBO; ZHAO QIANQIAN; LIU HONG; CAO WENQIA: "The development of Coronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 206, 6 August 2020 (2020-08-06), AMSTERDAM, NL , XP086299093, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2020.112711
AKAJI KENICHI, KONNO HIROYUKI: "Design and Evaluation of Anti-SARS-Coronavirus Agents Based on Molecular Interactions with the Viral Protease", MOLECULES, vol. 25, no. 17, pages 3920, XP055826867, DOI: 10.3390/molecules25173920
LIU YUZHI; LIANG CHENGYUAN; XIN LIANG; REN XIAODONG; TIAN LEI; JU XINGKE; LI HAN; WANG YONGBO; ZHAO QIANQIAN; LIU HONG; CAO WENQIA: "The development of Coronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 206, 6 August 2020 (2020-08-06), AMSTERDAM, NL , XP086299093, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2020.112711
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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