Title:
TRIAZOLE-LINKED CYCLIC DINUCLEOTIDE ANALOGUE
Document Type and Number:
WIPO Patent Application WO/2014/109256
Kind Code:
A1
Abstract:
Provided is a means for improving the chemical stability and lipid solubility of an artificial cyclic nucleoside linked body, which is an analogue of a naturally-occurring-type cyclic dinucleotide, while keeping the structural similarity to the naturally-occurring-type one. The present invention relates to a cyclic dinucleotide analogue having two nucleoside moieties each of which contains a purine base or a pyrimidine base and two linking groups each of which contains a 1,2,3-triazole ring and which link the two nucleoside moieties to each other to form a cyclic structure.
Inventors:
ISOBE HIROYUKI (JP)
FUJINO TOMOKO (JP)
OKADA KOHDAI (JP)
FUJINO TOMOKO (JP)
OKADA KOHDAI (JP)
Application Number:
PCT/JP2013/085042
Publication Date:
July 17, 2014
Filing Date:
December 27, 2013
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
C07H19/06; C07H19/16
Domestic Patent References:
| WO2005005450A1 | 2005-01-20 | |||
| WO2008120016A1 | 2008-10-09 |
Foreign References:
| JPH05186495A | 1993-07-27 | |||
| JP2007500697A | 2007-01-18 |
Other References:
LUO, Y. ET AL.: "Differential binding of 2'- biotinylated analogs of c-di-GMP with c-di-GMP riboswitches and binding proteins", MOLECULAR BIOSYSTEMS, vol. 8, no. 3, 2012, pages 772 - 778
GRAJKOWSKI A. ET AL.: "Convenient Synthesis of a Propargylated Cyclic (3'-5') Diguanylic Acid and Its ''Click'' Conjugation to a Biotinylated Azide", BIOCONJUGATE CHEMISTRY, vol. 21, no. 11, 2010, pages 2147 - 2152
LIETARD, J. ET AL.: "New Strategies for Cyclization and Bicyclization of Oligonucleotides by Click Chemistry Assisted by Microwaves", JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 1, 2008, pages 191 - 200
HIROYUKI ISOBE ET AL.: "Chemistry of Triazole- Linked Analogue of Nucleic Acids", JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, vol. 70, no. 8, 2012, JAPAN, pages 821 - 830
GRAJKOWSKI A. ET AL.: "Convenient Synthesis of a Propargylated Cyclic (3'-5') Diguanylic Acid and Its ''Click'' Conjugation to a Biotinylated Azide", BIOCONJUGATE CHEMISTRY, vol. 21, no. 11, 2010, pages 2147 - 2152
LIETARD, J. ET AL.: "New Strategies for Cyclization and Bicyclization of Oligonucleotides by Click Chemistry Assisted by Microwaves", JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 1, 2008, pages 191 - 200
HIROYUKI ISOBE ET AL.: "Chemistry of Triazole- Linked Analogue of Nucleic Acids", JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, vol. 70, no. 8, 2012, JAPAN, pages 821 - 830
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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