Title:
TRIAZOLYLATED TERTIARY AMINE COMPOUND OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/1993/005027
Kind Code:
A1
Abstract:
A triazolylated tertiary amine compound represented by general formula (I) or a salt thereof, having an aromatase inhibitory activity and being useful for preventing and treating breast cancer, mastopathy, endometriosis, prostatomegaly, etc., wherein A represents a single bond, lower alkylene or carbonyl; B represents lower alkyl, aryl, a 5- or 6-membered heterocyclic group, or a bicyclic fused heterocyclic group; D represents aryl, a 5- or 6-membered heterocyclic group, or a bicyclic fused heterocyclic group; and E represents 4H-1,2,4-triazolyl, 1H-1,2,4-triazolyl or 1H-1,2,3-triazolyl.
Inventors:
OKADA MINORU (JP)
KAWAMINAMI EIJI (JP)
YODEN TORU (JP)
KUDO MASAFUMI (JP)
ISOMURA YASUO (JP)
KAWAMINAMI EIJI (JP)
YODEN TORU (JP)
KUDO MASAFUMI (JP)
ISOMURA YASUO (JP)
Application Number:
PCT/JP1992/001089
Publication Date:
March 18, 1993
Filing Date:
August 27, 1992
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
International Classes:
A61K31/425; A61P35/00; C07D249/04; C07D249/08; C07D401/12; C07D403/12; C07D521/00; C12N9/00; (IPC1-7): A61K31/41; C07D249/04; C07D249/08; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D417/12
Foreign References:
| US4602025A | 1986-07-22 | |||
| US4609666A | 1986-09-02 | |||
| EP0293978A2 | 1988-12-07 | |||
| JPS63145270A | 1988-06-17 | |||
| EP0236940A2 | 1987-09-16 | |||
| EP0293978A2 | 1988-12-07 | |||
| US5041458A | 1991-08-20 |
Other References:
CLINICAL ENDOCRINOLOQY, vol. 32, 1990, pages 623
J. STEROID BIOCHEM. MOLEC. BIOL., vol. 37, no. 3, 1990, pages 335
BR. J. CANCER, vol. 60, 1989, pages 5
ENDOCRINOLOQY, vol. 126, no. 6, 1990, pages 3263
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 244, no. 2, 1988
ENDOCRINOL. JAPAN, vol. 37, no. 5, 1990, pages 719
STEROIDS, vol. 50, 1987, pages 1
J. BIOL. CHEM., vol. 249, 1974, pages 5364
J. VET., PHARMACOL. THERAP., vol. 11, 1988, pages 345
J. STEROID BIOCHEM., vol. 34, 1989, pages 567
ENDOCRINOLOQY, vol. 114, no. 2, 1984, pages 486
J. STEROID BIOCHEM. MOLEC. BIOL., vol. 37, no. 3, 1990, pages 335
BR. J. CANCER, vol. 60, 1989, pages 5
ENDOCRINOLOQY, vol. 126, no. 6, 1990, pages 3263
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 244, no. 2, 1988
ENDOCRINOL. JAPAN, vol. 37, no. 5, 1990, pages 719
STEROIDS, vol. 50, 1987, pages 1
J. BIOL. CHEM., vol. 249, 1974, pages 5364
J. VET., PHARMACOL. THERAP., vol. 11, 1988, pages 345
J. STEROID BIOCHEM., vol. 34, 1989, pages 567
ENDOCRINOLOQY, vol. 114, no. 2, 1984, pages 486
Attorney, Agent or Firm:
Nagai, Shozo (Patent Department, 1-8, Azusawa 1-chom, Itabashi-ku Tokyo 174, JP)
Download PDF: