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Title:
TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/259668
Kind Code:
A1
Abstract:
A compound represented by formula (I), an optical isomer thereof and a pharmaceutically acceptable salt thereof, as well as an application of said compound as an FXIa inhibitor.

Inventors:
GUO SHUCHUN (CN)
WANG JIANGWEI (CN)
YAO SHAN (CN)
ZHANG YONG (CN)
KANG ZHANGPING (CN)
ZHANG QIONG (CN)
YE YAN (CN)
PENG JIANBIAO (CN)
GUO HAIBING (CN)
Application Number:
PCT/CN2020/098412
Publication Date:
December 30, 2020
Filing Date:
June 28, 2020
Export Citation:
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Assignee:
SHANGHAI JEMINCARE PHARMACEUTICALS CO LTD (CN)
JIANGXI JEMINCARE GROUP CO LTD (CN)
International Classes:
C07D471/02; A61K31/444; A61P7/02; A61P9/00; A61P11/00; A61P43/00
Domestic Patent References:
WO2013118805A12013-08-15
Foreign References:
JP2017218449A2017-12-14
CN105228996A2016-01-06
CN201910578620A2019-06-28
CN202010129623A2020-02-28
CN202010561350A2020-06-18
Other References:
AVERY CRAIG A; PEASE RICHARD J; SMITH KERRIE; BOOTHBY MAY; BUCKLEY HELEN M; GRANT PETER J; FISHWICK COLIN W G: "(±) cis-bisamido epoxides: A novel series of potent FXIII-A inhibitors.", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 98, 16 May 2015 (2015-05-16), pages 49 - 53, XP029163234, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2015.05.019
RAMI A AL-HORANI; UMESH R DESAI: "Factor XIa inhibitors: A review of the patent literature.", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 26, no. 3, 3 March 2016 (2016-03-03), pages 323 - 345, XP055300510, ISSN: 1354-3776, DOI: 10.1517/13543776.2016.1154045
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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