Title:
TRICYCLIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/143864
Kind Code:
A1
Abstract:
The compound as shown in formula (I) or a pharmaceutically acceptable salt or pharmaceutical composition thereof, and a preparation method therefor, and the use thereof as an MAT2A inhibitor. Ring A, ring Q, X, Y, X1, X2, L and R1 in formula (I) are as defined in the description.
More Like This:
Inventors:
LI ZHEN (CN)
TANG FENG (CN)
LIU LE (CN)
ZHAO CHUNYAN (CN)
CHEN PING (CN)
TANG RENHONG (CN)
REN JINSHENG (CN)
TANG FENG (CN)
LIU LE (CN)
ZHAO CHUNYAN (CN)
CHEN PING (CN)
TANG RENHONG (CN)
REN JINSHENG (CN)
Application Number:
PCT/CN2021/142847
Publication Date:
July 07, 2022
Filing Date:
December 30, 2021
Export Citation:
Assignee:
JIANGSU SIMCERE PHARM CO LTD (CN)
International Classes:
C07D471/04; A61K31/519; A61P35/00; C07D519/00
Domestic Patent References:
| WO2020243376A1 | 2020-12-03 | |||
| WO2020139992A1 | 2020-07-02 | |||
| WO2018039972A1 | 2018-03-08 | |||
| WO2018045071A1 | 2018-03-08 | |||
| WO2019191470A1 | 2019-10-03 | |||
| WO2020123395A1 | 2020-06-18 | |||
| WO2017218960A1 | 2017-12-21 | |||
| WO2021139775A1 | 2021-07-15 |
Other References:
TAKUMI FURUTA, YUKI KITAMURA, AYANO HASHIMOTO, SATOSHI FUJII, KIYOSHI TANAKA, AND TOSHIYUKI KAN: "Efficient Synthesis of Phenanthridinone Derivatives via a Palladium-Catalyzed Coupling Process", ORGANIC LETTERS, vol. 9, no. 2, 16 December 2006 (2006-12-16), US , pages 183 - 186, XP008148682, ISSN: 1523-7060, DOI: 10.1021/ol062599z
THORAT VIJAYKUMAR H., UPADHYAY NITINKUMAR SATYADEV, MURAKAMI MASAHIRO, CHENG CHIEN-HONG: "Nickel-Catalyzed Denitrogenative Annulation of 1,2,3-Benzotriazin-4-(3 H )-ones with Benzynes for Construction of Phenanthridinone Scaffolds", ADVANCED SYNTHESIS AND CATALYSIS, vol. 360, no. 2, 17 January 2018 (2018-01-17), pages 284 - 289, XP055947034, ISSN: 1615-4150, DOI: 10.1002/adsc.201701143
MOON YONGHOON; JANG EUNYOUNG; CHOI SOYEON; HONG SUNGWOO: "Visible-Light-Photocatalyzed Synthesis of Phenanthridinones and Quinolinones via Direct Oxidative C-H Amidation", ORGANIC LETTERS, vol. 20, no. 1, 5 January 2018 (2018-01-05), US , pages 240 - 243, XP009525381, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b03600
KEHL ANTON, BREISING VALENTINA M., SCHOLLMEYER DIETER, WALDVOGEL SIEGFRIED R.: "Electrochemical Synthesis of 5-Aryl-phenanthridin-6-one by Dehydrogenative N,C Bond Formation", CHEMISTRY - A EUROPEAN JOURNAL, vol. 24, no. 65, 22 November 2018 (2018-11-22), DE, pages 17230 - 17233, XP055947036, ISSN: 0947-6539, DOI: 10.1002/chem.201804638
HONEYCUTT AARON P., HOOVER JESSICA M.: "Nickel-Catalyzed Oxidative Decarboxylative Annulation for the Synthesis of Heterocycle-Containing Phenanthridinones", ORGANIC LETTERS, vol. 20, no. 22, 16 November 2018 (2018-11-16), US , pages 7216 - 7219, XP055947037, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b03144
MENG YAN-YU, SI XIAO-JU, SONG YUAN-YUAN, ZHOU HUI-MIN, XU FEN: "Palladium-catalyzed decarbonylative annulation of phthalimides with arynes: direct construction of phenanthridinones", CHEMICAL COMMUNICATIONS, vol. 55, no. 64, 1 January 2019 (2019-01-01), UK , pages 9507 - 9510, XP055947041, ISSN: 1359-7345, DOI: 10.1039/C9CC04868E
CELL REPORTS, vol. 15, no. 3, 2016, pages 574 - 587
MAEHR, JCHEM.ED, vol. 62, 1985, pages 114 - 120
ANDREW CLARK, INTRODUCTION TO STEREOCHEMISTRY, 2020, pages 147 - 148
THORAT VIJAYKUMAR H., UPADHYAY NITINKUMAR SATYADEV, MURAKAMI MASAHIRO, CHENG CHIEN-HONG: "Nickel-Catalyzed Denitrogenative Annulation of 1,2,3-Benzotriazin-4-(3 H )-ones with Benzynes for Construction of Phenanthridinone Scaffolds", ADVANCED SYNTHESIS AND CATALYSIS, vol. 360, no. 2, 17 January 2018 (2018-01-17), pages 284 - 289, XP055947034, ISSN: 1615-4150, DOI: 10.1002/adsc.201701143
MOON YONGHOON; JANG EUNYOUNG; CHOI SOYEON; HONG SUNGWOO: "Visible-Light-Photocatalyzed Synthesis of Phenanthridinones and Quinolinones via Direct Oxidative C-H Amidation", ORGANIC LETTERS, vol. 20, no. 1, 5 January 2018 (2018-01-05), US , pages 240 - 243, XP009525381, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b03600
KEHL ANTON, BREISING VALENTINA M., SCHOLLMEYER DIETER, WALDVOGEL SIEGFRIED R.: "Electrochemical Synthesis of 5-Aryl-phenanthridin-6-one by Dehydrogenative N,C Bond Formation", CHEMISTRY - A EUROPEAN JOURNAL, vol. 24, no. 65, 22 November 2018 (2018-11-22), DE, pages 17230 - 17233, XP055947036, ISSN: 0947-6539, DOI: 10.1002/chem.201804638
HONEYCUTT AARON P., HOOVER JESSICA M.: "Nickel-Catalyzed Oxidative Decarboxylative Annulation for the Synthesis of Heterocycle-Containing Phenanthridinones", ORGANIC LETTERS, vol. 20, no. 22, 16 November 2018 (2018-11-16), US , pages 7216 - 7219, XP055947037, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b03144
MENG YAN-YU, SI XIAO-JU, SONG YUAN-YUAN, ZHOU HUI-MIN, XU FEN: "Palladium-catalyzed decarbonylative annulation of phthalimides with arynes: direct construction of phenanthridinones", CHEMICAL COMMUNICATIONS, vol. 55, no. 64, 1 January 2019 (2019-01-01), UK , pages 9507 - 9510, XP055947041, ISSN: 1359-7345, DOI: 10.1039/C9CC04868E
CELL REPORTS, vol. 15, no. 3, 2016, pages 574 - 587
MAEHR, JCHEM.ED, vol. 62, 1985, pages 114 - 120
ANDREW CLARK, INTRODUCTION TO STEREOCHEMISTRY, 2020, pages 147 - 148
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
Download PDF:
Previous Patent: POSITIONING METHOD ON SIDELINK (SL), TERMINAL, AND NETWORK SIDE DEVICE
Next Patent: FLUID CONTROL ASSEMBLY AND FLUID CONTROL DEVICE
Next Patent: FLUID CONTROL ASSEMBLY AND FLUID CONTROL DEVICE