Title:
TRICYCLIC DIHYDRO-QUINOLINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO2002094840
Kind Code:
A3
Abstract:
The invention concerns a compound of formula (I), wherein: (a) represents a single or double bond; (b) represents a cycle selected among (i), (ii), (iii), (iv) and (v); R9a, R9b, R9c, X and Y are such as defined in the description; R1 represents a group selected among hydrogen, aryl, heteroaryl, cycloalkyl, alkyl optionally substituted, and COR11, wherein R11 is such as defined in the description; R2 to R8 represent each a group selected among hydrogen, halogen, hydroxy, polyhalogenoalkyl, nitro, alkyl optionally substituted, amino optionally substituted, alkoxy optionally substituted, -OPO(OH)2 and (II), wherein m represents an integer such that 1
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Inventors:
HUSSON HENRI-PHILIPPE (FR)
GIORGI-RENAULT SYLVIANE (FR)
DESBENE STEPHANIE (FR)
HICKMAN JOHN (FR)
PIERRE ALAIN (FR)
KRAUS-BERTHIER LAURENCE (FR)
PFEIFFER BRUNO (FR)
RENARD PIERRE (FR)
GIORGI-RENAULT SYLVIANE (FR)
DESBENE STEPHANIE (FR)
HICKMAN JOHN (FR)
PIERRE ALAIN (FR)
KRAUS-BERTHIER LAURENCE (FR)
PFEIFFER BRUNO (FR)
RENARD PIERRE (FR)
Application Number:
PCT/FR2002/001716
Publication Date:
May 01, 2003
Filing Date:
May 22, 2002
Export Citation:
Assignee:
SERVIER LAB (FR)
HUSSON HENRI-PHILIPPE (FR)
GIORGI-RENAULT SYLVIANE (FR)
DESBENE STEPHANIE (FR)
HICKMAN JOHN (FR)
PIERRE ALAIN (FR)
KRAUS-BERTHIER LAURENCE (FR)
PFEIFFER BRUNO (FR)
RENARD PIERRE (FR)
HUSSON HENRI-PHILIPPE (FR)
GIORGI-RENAULT SYLVIANE (FR)
DESBENE STEPHANIE (FR)
HICKMAN JOHN (FR)
PIERRE ALAIN (FR)
KRAUS-BERTHIER LAURENCE (FR)
PFEIFFER BRUNO (FR)
RENARD PIERRE (FR)
International Classes:
A61K31/4741; A61K31/4743; A61K31/4745; A61K31/661; A61P35/00; C07D471/04; C07D491/04; C07D491/048; C07D491/056; C07D491/14; C07D497/04; C07F9/60; C07F9/6561; (IPC1-7): C07F9/6561; C07D491/14; C07D491/04
Foreign References:
| EP1103554A1 | 2001-05-30 |
Other References:
MATSUO, K.; KOBAYASHI, M.: "Synthesis and reaction of 9-aryl-1H,3H-thieno[3,4-b]-quinolin-1-ones", CHEM. EXPRESS, vol. 8, no. 6, 1993, pages 389 - 92, XP001053563
HITOTSUYANAGI Y Y ET AL: "4-Aza-2,3-dehydro-4-deoxypodophyllotoxins: simple aza-podophyllotoxin analogues possessing potent cytotoxicity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 10, no. 4, February 2000 (2000-02-01), pages 315 - 317, XP004189922, ISSN: 0960-894X
HITOTSUYANAGI Y Y ET AL: "4-Aza-2,3-dehydro-4-deoxypodophyllotoxins: simple aza-podophyllotoxin analogues possessing potent cytotoxicity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 10, no. 4, February 2000 (2000-02-01), pages 315 - 317, XP004189922, ISSN: 0960-894X
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