TRICYCLIC FUSED HETEROCYCLE COMPOUNDS, PROCESS FOR PREPARING THE SAME AND USE THEREOF

Title:

TRICYCLIC FUSED HETEROCYCLE COMPOUNDS, PROCESS FOR PREPARING THE SAME AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO2000075127

Kind Code:

A8

Abstract:

Compounds represented by general formula (1) or pharmaceutically acceptable salts thereof. In said formula, X is CH, CH2, CHR (wherein R is lower alkyl or substituted lower alkyl), or CRR' (wherein R and R' are each as defined above as to R); Y is CH, CH2, or C=O; Z is O, S, S=O, or SO2; U is C or N; R1 to R4 are each independently hydrogen, OR, SR (wherein R is as defined above), an aromatic ring, a heterocycle, or the like; and at least one of R5 to R8 is OH. The compounds exhibit excellent pharmacological activities such as relaxation of tracheal smooth muscle, suppression of respiratory tract hypersensitiveness, and inhibition of phlogocytic infiltration into the respiratory tract.

Inventors:

JINNO SHUJI (JP)
OKITA TAKAAKI (JP)
OHTSUKA NAOMI (JP)
YAMASHITA SHINYA (JP)
HATA JUNICHIRO (JP)
TAKEO JIRO (JP)

Application Number:

PCT/JP2000/003592

Publication Date:

March 15, 2001

Filing Date:

June 02, 2000

Export Citation:

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Assignee:

NIPPON SUISAN KAISHA LTD (JP)
JINNO SHUJI (JP)
OKITA TAKAAKI (JP)
OHTSUKA NAOMI (JP)
YAMASHITA SHINYA (JP)
HATA JUNICHIRO (JP)
TAKEO JIRO (JP)

International Classes:

A61K31/31; A61K31/335; A61K31/343; A61K31/38; A61K31/381; A61K31/4353; A61K31/4427; A61P11/06; A61P11/08; A61P29/00; C07D313/14; C07D337/14; C07D405/04; C07D407/04; C07D409/04; C07D491/04; (IPC1-7): C07D313/14; C07D337/14; C07D405/04; C07D407/04; C07D409/04; C07D491/06; A61K31/31; A61K31/335; A61K31/343; A61K31/38; A61K31/381; A61K31/4353; A61K31/4427; A61P11/06; A61P11/08; A61P29/00

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