TRICYCLIC FUSED-IMIDAZOLE DERIVATIVES

WIPO Patent Application WO/2001/029038

A1

Tricyclic fused-imidazole derivatives of general formula (1), which exhibit an inhibitory activity against cyclooxygenase 2 and little cause adverse reaction. In said formula, R?1¿ is lower alkylthio, lower alkylsulfonyl, halogeno, or the like; R?2¿ is hydrogen, lower alkoxyl, halogeno, or the like; X-A is -CH¿2?CH¿2?-, -OCH¿2?-, -SCH¿2?-, or the like; and Y-Z is =C-N=, =N-C=, or =C-C= with the proviso that lower alky or other substituent may be bonded to each carbon atom.

YAEGASHI TAKASHI (JP)
NISHIYAMA HIROYUKI (JP)
HENMI TOSHIYUKI (JP)
SAWADA SEIGO (JP)

PCT/JP2000/007201

April 26, 2001

October 18, 2000

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YAKULT HONSHA KK (JP)
YAEGASHI TAKASHI (JP)
NISHIYAMA HIROYUKI (JP)
HENMI TOSHIYUKI (JP)
SAWADA SEIGO (JP)

C07D487/04; A61K31/407; A61K31/4188; A61K31/4745; A61K31/5383; A61K31/542; A61K31/55; A61P29/00; A61P43/00; C07D471/04; C07D498/04; C07D513/04; (IPC1-7): C07D471/04; A61K31/407; A61K31/4188; A61K31/4745; A61K31/5383; A61K31/542; A61P29/00; A61P43/00; C07D487/04; C07D498/04; C07D513/04

US5547975A	1996-08-20
JPS61118386A	1986-06-05

SHRISHAR D.R.: "Synthesis & biological activity of some substituted 4H-(1,2,4)triazolo(3,4-c)(1,4)benzoxazines & 4H-(1,2,4)triazolo(3,4-c)(1,4)benzothiazines", INDIAN J. CHEM., vol. 23B, no. 5, 1984, pages 445 - 448, XP002935881
GAROFALO A.: "Synthesis and biological evaluation of conformationally restricted analogs of tolmetin and ketorolac", MED. CHEM. RES., vol. 4, no. 6, 1994, pages 385 - 395, XP002935882

Kuzuwa, Kiyoshi (Honshio-cho 19 Shinjuku-ku Tokyo, JP)

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