Title:
TRICYCLIC HETEROCYCLE COMPOUNDS AS IAP ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO/2023/169569
Kind Code:
A1
Abstract:
The present disclosure relates to compounds that inhibit IAP (preferably cIAP1, cIAP2 or XIAP) protein, pharmaceutical compositions comprising the same and methods of using the IAP protein inhibitors in the treatment of diseases and conditions wherein inhibition of IAP protein provides a benefit.
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Inventors:
HU JIANTAO (CN)
CHEN JIANYONG (CN)
LIU FANG (CN)
ZHAO LEILEI (CN)
HE BAOLIN (CN)
CHEN HAO (CN)
ZHA XIANCHAN (CN)
ZHOU RUBIN (CN)
ZHANG JUN (CN)
WANG JIAWEI (CN)
SHI HUIFANG (CN)
CHEN JIANYONG (CN)
LIU FANG (CN)
ZHAO LEILEI (CN)
HE BAOLIN (CN)
CHEN HAO (CN)
ZHA XIANCHAN (CN)
ZHOU RUBIN (CN)
ZHANG JUN (CN)
WANG JIAWEI (CN)
SHI HUIFANG (CN)
Application Number:
PCT/CN2023/080856
Publication Date:
September 14, 2023
Filing Date:
March 10, 2023
Export Citation:
Assignee:
ASCENTAGE PHARMA SUZHOU CO LTD (CN)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
International Classes:
C07D471/14; A61K31/437; A61P35/00
Foreign References:
| CN103492376A | 2014-01-01 | |||
| US20170224705A1 | 2017-08-10 | |||
| CN104870440A | 2015-08-26 | |||
| CN104870441A | 2015-08-26 | |||
| CN104870442A | 2015-08-26 |
Other References:
C.N. JOHNSON ET. AL.: "A Fragment Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl)-2-[(2R,5R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)-piperazin-1-yl)ethan-1-one.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, no. 16, 9 August 2018 (2018-08-09), pages 7314 - 7329, XP002803421, DOI: 10.1021/acs.jmedchem.8b00900
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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