Title:
TRICYCLIC PYRIDIN-2-ONE ANALOGUES AS LIGANDS FOR GABA-A RECEPTORS
Document Type and Number:
WIPO Patent Application WO2003018546
Kind Code:
A3
Abstract:
A class of selectively substituted fused tricyclic compounds based on a substituted pyridinone moiety are potent and functionally selective ligands for the alpha 2/ alpha 3 subunit of the human GABA-A receptor and are thereby effective in the treatment of anxiety.
Inventors:
BOURRAIN SYLVIE (GB)
GOODACRE SIMON CHARLES (GB)
HALLETT DAVID JAMES (GB)
LEWIS RICHARD THOMAS (GB)
ROWLEY MICHAEL (IT)
STERNFELD FRANCINE (GB)
STREET LESLIE JOSEPH (GB)
GOODACRE SIMON CHARLES (GB)
HALLETT DAVID JAMES (GB)
LEWIS RICHARD THOMAS (GB)
ROWLEY MICHAEL (IT)
STERNFELD FRANCINE (GB)
STREET LESLIE JOSEPH (GB)
Application Number:
PCT/GB2002/003703
Publication Date:
July 17, 2003
Filing Date:
August 12, 2002
Export Citation:
Assignee:
MERCK SHARP & DOHME (GB)
BOURRAIN SYLVIE (GB)
GOODACRE SIMON CHARLES (GB)
HALLETT DAVID JAMES (GB)
LEWIS RICHARD THOMAS (GB)
ROWLEY MICHAEL (IT)
STERNFELD FRANCINE (GB)
STREET LESLIE JOSEPH (GB)
BOURRAIN SYLVIE (GB)
GOODACRE SIMON CHARLES (GB)
HALLETT DAVID JAMES (GB)
LEWIS RICHARD THOMAS (GB)
ROWLEY MICHAEL (IT)
STERNFELD FRANCINE (GB)
STREET LESLIE JOSEPH (GB)
International Classes:
A61P25/22; C07D471/14; (IPC1-7): C07D471/16; A61P25/22
Domestic Patent References:
| WO1998050384A1 | 1998-11-12 |
Foreign References:
| US5512590A | 1996-04-30 |
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