Title:
TRIENTINE TETRAHYDROCHLORIDE, AND PREPARATION METHOD THEREFOR AND COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/160520
Kind Code:
A1
Abstract:
The present application provides a preparation method for a trientine tetrahydrochloride crystal. The preparation method comprises: adding an anti-solvent to an aqueous trientine tetrahydrochloride solution at a feeding temperature, and stirring the resulting mixture to precipitate a crystal, wherein the feeding temperature is 50-75ºC, and the anti-solvent is an alcohol solvent. The present application also provides a new trientine tetrahydrochloride. In an XRPD pattern of the crystal thereof, peak values are present when 2θ is equal to 21.9, 24.8, 25.2, 28.0 and 35.6 ± 0.1º. A composition prepared from the trientine tetrahydrochloride of the present application has the advantage of stable storage.
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Inventors:
PERNG CHERNG-YIH (CN)
LIANG MING-REN (CN)
LIN YU-CHEN (CN)
FENG TAI-YUN (CN)
LIANG MING-REN (CN)
LIN YU-CHEN (CN)
FENG TAI-YUN (CN)
Application Number:
PCT/CN2023/077332
Publication Date:
August 31, 2023
Filing Date:
February 21, 2023
Export Citation:
Assignee:
YU JET CO LTD (CN)
International Classes:
A61K31/132; C07C211/14; A61P1/16; A61P25/00; A61P43/00
Domestic Patent References:
| WO2006027705A2 | 2006-03-16 |
Foreign References:
| CN111479798A | 2020-07-31 | |||
| CS197093B1 | 1980-04-30 |
Other References:
D. H. PEACOCK: "322. Polyamines. Part II. The preparation of ββ′-diaminodiethylamine and NN′-bis-(β-aminoethyl)ethylenediamine", JOURNAL OF THE CHEMICAL SOCIETY, 1 January 1936 (1936-01-01), pages 1518 - 1520, XP055519217, ISSN: 0368-1769, DOI: 10.1039/JR9360001518
BASELT, RANDALL C.; SUNDERMAN, F. WILLIAM, JR.; MITCHELL, JOHN; HORAK, EVA: "Comparisons of antidotal efficacy of sodium diethyldithiocarbamate, D-penicillamine and triethylenetetramine upon acute toxicity of nickel carbonyl in rats", RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY., PJD PUBLICATIONS LTD., WESTBURY, NY., US, vol. 18, no. 4, 1 December 1977 (1977-12-01), US , pages 677 - 88, XP009508982, ISSN: 0034-5164
ALLEN, K. G. D.; TWEDT, D. C.; HUNSAKER, H. A.: "Tetramine cupruretic agents: a comparison in dogs", AMERICAN JOURNAL OF VETERINARY RESEARCH, AMERICAN VETERINARY MEDICINE ASSOCIATION, US, vol. 48, no. 1, 1 January 1987 (1987-01-01), US , pages 28 - 30, XP009508978, ISSN: 0002-9645
BERNAL IVAN, CETRULLO JAMES: "The Phenomenon of Conglomerate Crystallization. XII. Spontaneous Resolution in Coordination Compounds. IX. The Structure of Racemic [cis+Rh(trien)(NOz)2]CI", INORGANICA CHIMICA ACTA, vol. 144, no. 2, 1 January 1988 (1988-01-01), pages 227 - 232, XP093085769
BRUCE L. MAY, SUZANNA D. KEAN, CHRISTOPHER J. EASTON, STEPHEN F. LINCOLN: "Preparation and characterization of 6A-polyamine-mono-substituted β-cyclodextrins", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, UK, vol. 1, no. 21, 1 January 1997 (1997-01-01), Cambridge, UK , pages 3157 - 3160, XP055278917, ISSN: 0300-922X, DOI: 10.1039/a704467d
BASELT, RANDALL C.; SUNDERMAN, F. WILLIAM, JR.; MITCHELL, JOHN; HORAK, EVA: "Comparisons of antidotal efficacy of sodium diethyldithiocarbamate, D-penicillamine and triethylenetetramine upon acute toxicity of nickel carbonyl in rats", RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY., PJD PUBLICATIONS LTD., WESTBURY, NY., US, vol. 18, no. 4, 1 December 1977 (1977-12-01), US , pages 677 - 88, XP009508982, ISSN: 0034-5164
ALLEN, K. G. D.; TWEDT, D. C.; HUNSAKER, H. A.: "Tetramine cupruretic agents: a comparison in dogs", AMERICAN JOURNAL OF VETERINARY RESEARCH, AMERICAN VETERINARY MEDICINE ASSOCIATION, US, vol. 48, no. 1, 1 January 1987 (1987-01-01), US , pages 28 - 30, XP009508978, ISSN: 0002-9645
BERNAL IVAN, CETRULLO JAMES: "The Phenomenon of Conglomerate Crystallization. XII. Spontaneous Resolution in Coordination Compounds. IX. The Structure of Racemic [cis+Rh(trien)(NOz)2]CI", INORGANICA CHIMICA ACTA, vol. 144, no. 2, 1 January 1988 (1988-01-01), pages 227 - 232, XP093085769
BRUCE L. MAY, SUZANNA D. KEAN, CHRISTOPHER J. EASTON, STEPHEN F. LINCOLN: "Preparation and characterization of 6A-polyamine-mono-substituted β-cyclodextrins", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, UK, vol. 1, no. 21, 1 January 1997 (1997-01-01), Cambridge, UK , pages 3157 - 3160, XP055278917, ISSN: 0300-922X, DOI: 10.1039/a704467d
Attorney, Agent or Firm:
DRAGON INTELLECTUAL PROPERTY LAW FIRM (CN)
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