Title:
TRIFLUOROMETHYL-SUBSTITUTED SULFONAMIDE AS BCL-2-SELECTIVE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/185025
Kind Code:
A1
Abstract:
The present invention relates to trifluoromethyl-substituted sulfonamide as a BCL-2-selective inhibitor. In particular, the present invention relates to a compound of formula (I) or a stereoisomer or pharmaceutically acceptable salt thereof and a pharmaceutical composition comprising the compound. The present invention also relates to uses of the compound and the pharmaceutical composition comprising the compound in treating diseases related to an anti-apoptotic protein, BCL-2, such as cancer.
Inventors:
LIU FEI (CN)
FENG WEIWEI (CN)
WANG BIN (CN)
XU HONGJIANG (CN)
WANG JINAN (CN)
ZHANG XIQUAN (CN)
WANG SHANCHUN (CN)
SHI WEI (CN)
ZHANG JIANQING (CN)
YAO YIYAN (CN)
LIU YANLONG (CN)
LI YANG (CN)
LIU LIMIN (CN)
GU HONGMEI (CN)
YANG LING (CN)
DONG PING (CN)
TIAN XIN (CN)
CHEN ZHILIN (CN)
ZHOU HAO (CN)
FENG WEIWEI (CN)
WANG BIN (CN)
XU HONGJIANG (CN)
WANG JINAN (CN)
ZHANG XIQUAN (CN)
WANG SHANCHUN (CN)
SHI WEI (CN)
ZHANG JIANQING (CN)
YAO YIYAN (CN)
LIU YANLONG (CN)
LI YANG (CN)
LIU LIMIN (CN)
GU HONGMEI (CN)
YANG LING (CN)
DONG PING (CN)
TIAN XIN (CN)
CHEN ZHILIN (CN)
ZHOU HAO (CN)
Application Number:
PCT/CN2019/080435
Publication Date:
October 03, 2019
Filing Date:
March 29, 2019
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07D471/04; A61K31/404; A61P35/00; C07D211/96; C07D215/20
Domestic Patent References:
| WO2010065824A2 | 2010-06-10 |
Foreign References:
| CN104876927A | 2015-09-02 | |||
| CN102307872A | 2012-01-04 |
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
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