Title:
TRIMERIC BINDING PROTEINS FOR TRIMERIC CYTOKINES
Document Type and Number:
WIPO Patent Application WO2004039841
Kind Code:
A3
Abstract:
The present invention pertains to the provision of trimeric binding units which bind to trimeric cytokines. In particular there is provided a trimeric polypeptide comprising a trimerising domain and three monomers with binding members capable of binding a trimeric cytokine. Preferably , the trimeric binding units bind in a manner such that upon binding, all receptor binding sites of the trimeric cytokine are substantially blocked, and hence the potential biological activity of the trimeric cytokine is suppressed. In one aspect the invention relates to trimeric binders capable of binding to trimeric cytokines of the Tumor necrosis factor ligand superfamily, such as TNF, TRAIL, RANKL, TWEAK, APRIL and BAFF.
Inventors:
HOLTET THOR LAS (DK)
ANDERSEN MIKKEL HOLMEN (DK)
OTTOW HELLE KROGH (DK)
ANDERSEN MIKKEL HOLMEN (DK)
OTTOW HELLE KROGH (DK)
Application Number:
PCT/DK2003/000735
Publication Date:
September 10, 2004
Filing Date:
October 29, 2003
Export Citation:
Assignee:
BOREAN PHARMA AS (DK)
HOLTET THOR LAS (DK)
ANDERSEN MIKKEL HOLMEN (DK)
OTTOW HELLE KROGH (DK)
HOLTET THOR LAS (DK)
ANDERSEN MIKKEL HOLMEN (DK)
OTTOW HELLE KROGH (DK)
International Classes:
A61P29/00; C07K14/525; C07K14/715; C07K16/24; C12N5/28; C12N15/62; G01N33/68; A61K38/00; (IPC1-7): C07K14/52; A61K38/19; A61P29/00; C07K14/525; C07K14/725; C12N5/10; C12N5/28; C12N15/10; G01N33/68
Domestic Patent References:
| WO2003060072A2 | 2003-07-24 | |||
| WO2003033720A2 | 2003-04-24 | |||
| WO2003057856A2 | 2003-07-17 | |||
| WO2001064889A2 | 2001-09-07 | |||
| WO1998005783A1 | 1998-02-12 | |||
| WO1999011791A2 | 1999-03-11 | |||
| WO2004012673A2 | 2004-02-12 |
Foreign References:
| US20030119149A1 | 2003-06-26 | |||
| US20030053984A1 | 2003-03-20 |
Other References:
BODMER JEAN-LUC ET AL: "The molecular architecture of the TNF superfamily.", TRENDS IN BIOCHEMICAL SCIENCES. ENGLAND JAN 2002, vol. 27, no. 1, January 2002 (2002-01-01), pages 19 - 26, XP002276709, ISSN: 0968-0004
KORNBLUTH RICHARD S: "An expanding role for CD40L and other tumor necrosis factor superfamily ligands in HIV infection.", JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH. UNITED STATES OCT 2002, vol. 11, no. 5, October 2002 (2002-10-01), pages 787 - 801, XP002276710, ISSN: 1525-8165
IDRISS H T ET AL: "TNF alpha and the TNF receptor superfamily: structure-function relationship(s).", MICROSCOPY RESEARCH AND TECHNIQUE. UNITED STATES 1 AUG 2000, vol. 50, no. 3, 1 August 2000 (2000-08-01), pages 184 - 195, XP002276711, ISSN: 1059-910X
KORNBLUTH RICHARD S: "An expanding role for CD40L and other tumor necrosis factor superfamily ligands in HIV infection.", JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH. UNITED STATES OCT 2002, vol. 11, no. 5, October 2002 (2002-10-01), pages 787 - 801, XP002276710, ISSN: 1525-8165
IDRISS H T ET AL: "TNF alpha and the TNF receptor superfamily: structure-function relationship(s).", MICROSCOPY RESEARCH AND TECHNIQUE. UNITED STATES 1 AUG 2000, vol. 50, no. 3, 1 August 2000 (2000-08-01), pages 184 - 195, XP002276711, ISSN: 1059-910X
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