Title:
TRIPLET-TRIPLET ANNIHILATION UPCONVERSION NANOPARTICLES BASED SELF-STANDING BIOLOGICAL SENSORS, AND DEVICES AND METHODS THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/177560
Kind Code:
A3
Abstract:
The invention provides novel triplet-triplet annihilation upconversion nanoparticles as background free self-standing biological sensors, and devices and methods thereof. The invention provides novel and simple enzymatic strategy to overcome oxygen-induced triplet-triplet annihilation upconversion quenching. The disclosed invention addresses the long-felt challenges in aqueous TTA-UC due to its sensitivity to oxygen, which has hindered TTAUC's biological applications under ambient atmosphere This novel strategy stems from glucose oxidase catalyzed glucose oxidation reaction, which enables rapid oxygen depletion to turn on upconversion in the aqueous solution. Furthermore, self-standing upconversion biological sensors of such nanoparticles are developed to detect glucose and measure the activity of enzymes related to glucose metabolism in a highly specific, sensitive, and background-free manner.
More Like This:
Inventors:
HAN GANG (US)
HUANG LING (US)
HUANG LING (US)
Application Number:
PCT/US2023/014749
Publication Date:
November 16, 2023
Filing Date:
March 07, 2023
Export Citation:
Assignee:
UNIV MASSACHUSETTS (US)
International Classes:
G01N21/63; C07F5/02; C07F15/00; C09B5/00; C09K11/06; G01N21/64; H01S3/00
Foreign References:
| US20180311353A1 | 2018-11-01 |
Other References:
HUANG LING, LE TIMMY, HUANG KAI, HAN GANG: "Enzymatic enhancing of triplet–triplet annihilation upconversion by breaking oxygen quenching for background-free biological sensing", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 12, no. 1, UK, XP093112285, ISSN: 2041-1723, DOI: 10.1038/s41467-021-22282-1
Attorney, Agent or Firm:
ZHANG, Yin, Philip (US)
Download PDF: