Title:
TRIPTOLIDE DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/192031
Kind Code:
A1
Abstract:
Disclosed are a triptolide derivative and a preparation method therefor and the use thereof. The triptolide derivative has the structure as shown in general formula I, and the definition of each substituent is as described in the description and claims. The triptolide derivative of the present invention has a better immunosuppressive activity and anti-tumor activity, and low toxicity and high safety, thus having good development and application prospects.
Inventors:
XIAO FEI (CN)
QIU BO (CN)
ZHANG PENG (CN)
QIU BO (CN)
ZHANG PENG (CN)
Application Number:
PCT/CN2018/083525
Publication Date:
October 10, 2019
Filing Date:
April 18, 2018
Export Citation:
Assignee:
CINKATE PHARMACEUTICAL INTERMEDIATES CO LTD (CN)
CINKATE PHARM TECH SHANGHAI CO LTD (CN)
CINKATE PHARM TECH SHANGHAI CO LTD (CN)
International Classes:
C07J73/00; A61K31/58; A61P35/00; A61P37/00
Foreign References:
| CN1925852A | 2007-03-07 | |||
| CN107663225A | 2018-02-06 |
Other References:
XU, HONGTAO ET AL.: "Design, Synthesis and Structure-Activity Relationships Studies on the D Ring of the Natural Product Triptolide", CHEMMEDCHEM, vol. 9, no. 2, 11 November 2013 (2013-11-11), pages 290 - 295, XP009520313, DOI: 10.1002/cmdc.201300409
SAMBROOK ET AL.: "Molecular Cloning: Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3699184A4
SAMBROOK ET AL.: "Molecular Cloning: Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3699184A4
Attorney, Agent or Firm:
XU AND PARTNERS, LLC. (CN)
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