Title:
TRIPTOLIDE LIGNOCERATE, LIPOSOME THEREOF AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/221961
Kind Code:
A1
Abstract:
The present invention relates to the technical field of pharmaceutics, and in particular to a triptolide lignocerate, a liposome thereof and a preparation method therefor. The chemical structural formula of the triptolide lignocerate is represented by formula (I). The triptolide lignocerate provided by the present invention is obtained by esterification of triptolide C14-OH and lignoceric acid. The anti-tumor effectiveness, safety and the like of the triptolide lignocerate liposome are further improved with respect to the prior art, so that a foundation is laid for providing safer and more effective triptolide-related clinical preparations.
Inventors:
WU XIN (CN)
CHEN XING (CN)
CHEN XINMEI (CN)
CHEN JIANMING (CN)
WU YONGJIE (CN)
WEI WUHAO (CN)
WANG XINYU (CN)
LIU MENGMENG (CN)
CHEN XING (CN)
CHEN XINMEI (CN)
CHEN JIANMING (CN)
WU YONGJIE (CN)
WEI WUHAO (CN)
WANG XINYU (CN)
LIU MENGMENG (CN)
Application Number:
PCT/CN2023/094423
Publication Date:
November 23, 2023
Filing Date:
May 16, 2023
Export Citation:
Assignee:
SHANGHAI WEI ER BIOPHARMACEUTICAL TECH CO LTD (CN)
SHANGHAI BAOLONG PHARMACEUTICAL CO LTD (CN)
BAOLONG PHARMACEUTICAL CO LTD (CN)
SHANGHAI BAOLONG ANQING PHARMACEUTICAL CO LTD (CN)
SHANGHAI BAOLONG PHARMACEUTICAL CO LTD (CN)
BAOLONG PHARMACEUTICAL CO LTD (CN)
SHANGHAI BAOLONG ANQING PHARMACEUTICAL CO LTD (CN)
International Classes:
C07J73/00; A61K9/127; A61K31/585; A61K47/26; A61P35/00
Foreign References:
| CN106946975A | 2017-07-14 | |||
| CN1377282A | 2002-10-30 | |||
| US20190076357A1 | 2019-03-14 | |||
| CN105853403A | 2016-08-17 |
Attorney, Agent or Firm:
SHANGHAI SUNHOLD LAW FIRM (CN)
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