TRPV4 INHIBITOR AS THERAPEUTIC DRUG FOR EYE DISEASE

WIPO Patent Application WO/2022/014707

A1

The present invention relates to the use of a compound having TRPV4 inhibitory activity, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing these, in the manufacture of a pharmaceutical product for the prevention or treatment of retinal disease that accompanies vascular disorders or cellular disorders. Further, the invention relates to a method of preventing or treating the aforementioned diseases, involving administering said compound or a pharmaceutical composition containing the same to a human or animal. Said compound, pharmaceutically acceptable salt thereof, or pharmaceutical composition containing these may be used in combination with one or more second active drugs. The invention relates to a kit and a pharmaceutical composition, used for the prevention or treatment of the aforementioned diseases and containing a compound having TRPV4 inhibitory activity or a pharmaceutically acceptable salt thereof. The invention further relates to a marker for diagnosing diseases usefully treated by said compound, and a method for screening drugs that prevent or treat the aforementioned diseases.

OHARA KENTARO (JP)
WATANABE SHUZO (JP)
HARA HIDEAKI (JP)
SHIMAZAWA MASAMITSU (JP)
SUGARU EIJI (JP)

PCT/JP2021/026829

January 20, 2022

July 16, 2021

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RAQUALIA PHARMA INC (JP)

A61K45/00; A61K31/4709; A61K31/497; A61K31/5377; A61K39/395; A61K48/00; A61P27/02; A61P27/06; G01N33/50

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IWATANI Ryo (JP)

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