Title:
TRUNCATED TACI POLYPEPTIDE AND FUSION PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/206872
Kind Code:
A1
Abstract:
The present application relates to a truncated TACI polypeptide and a fusion protein and use thereof. Specifically, provided are a TACI polypeptide as shown in SEQ ID NO: 8, a truncated fragment thereof, a mutation sequence thereof, and a fusion protein comprising the TACI polypeptide and use thereof.
Inventors:
MAO LANGYONG (CN)
YING HUA (CN)
JIN XINSHENG (CN)
LI LINGLING (CN)
TAO WEIKANG (CN)
YING HUA (CN)
JIN XINSHENG (CN)
LI LINGLING (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2022/084256
Publication Date:
October 06, 2022
Filing Date:
March 31, 2022
Export Citation:
Assignee:
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K14/00; A61P37/02; C07K19/00; C12N15/62
Domestic Patent References:
| WO1996027011A1 | 1996-09-06 | |||
| WO1998050431A2 | 1998-11-12 | |||
| WO2007110205A2 | 2007-10-04 | |||
| WO2007147901A1 | 2007-12-27 | |||
| WO2009089004A1 | 2009-07-16 | |||
| WO2010129304A2 | 2010-11-11 | |||
| WO2011090754A1 | 2011-07-28 | |||
| WO2011143545A1 | 2011-11-17 | |||
| WO2012058768A1 | 2012-05-10 | |||
| WO2013157954A1 | 2013-10-24 | |||
| WO2013096291A2 | 2013-06-27 | |||
| WO2015173782A1 | 2015-11-19 |
Foreign References:
| CN101323643A | 2008-12-17 | |||
| CN101854951A | 2010-10-06 | |||
| US20090311732A1 | 2009-12-17 | |||
| US20100261887A1 | 2010-10-14 | |||
| CN202110348497A | 2021-03-31 | |||
| EP1870459A1 | 2007-12-26 | |||
| US5959177A | 1999-09-28 | |||
| US6040498A | 2000-03-21 | |||
| US6420548B1 | 2002-07-16 | |||
| US7125978B1 | 2006-10-24 | |||
| US6417429B1 | 2002-07-09 |
Other References:
BAI WU-RENTUYA, ZHAO YA-CONG;ZHU YAN-FENG;SHI YU;SUN JIAN: "Construction, Expression and Activity Analysis of sTACI-Fc-Myc Protein*", PROGRESS IN MODERN BIOMEDICINE, XIAN DAI SHENG WU YI XUE JIN ZHAN BIAN JI BU, CN, vol. 15, no. 2, 20 January 2015 (2015-01-20), CN , pages 217 - 220, XP055974633, ISSN: 1673-6273, DOI: 10.13241/j.cnki.pmb.2015.02.004
XU HAI-YAN, YONG WANG, GE-HUA YU, HONG-BING MA, YING XU, QIN SHI: "The Regulatory Role of Human TACI-Fc Fusion Protein to XG6 Cell Line in Vitro", CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY, vol. 25, no. 11, 28 November 2005 (2005-11-28), pages 912 - 916, XP055782083
TSOKOS, G.C. ET AL., NAT REV RHEUMATOL, vol. 12, 2016, pages 716 - 730
LAROSA, M. ET AL., EXPERT REV CLIN IMMUNOL, vol. 12, 2016, pages 1309 - 1320
MURPHY, G.D.A. ISENBERG, NAT REV RHEUMATOL, vol. 15, 2019, pages 403 - 412
LAM, N.C.M.V. GHETUM.L. BIENIEK, AM FAM PHYSICIAN, vol. 94, 2016, pages 284 - 294
MOSCHEN, A.R.H. TILGT. RAINE, NAT REV GASTROENTEROL HEPATOL, vol. 16, 2019, pages 185 - 196
FRIEDER, J. ET AL., CLIN PHARMACOL THER, vol. 103, 2018, pages 88 - 101
LEE, E.B. ET AL., CUTIS, vol. 101, 2018, pages 5 - 9
FLOSS, D.M. ET AL., CYTOKINE GROWTH FACTOR REV, vol. 26, 2015, pages 569 - 578
SAMY, E. ET AL., INT REV IMMUNOL, vol. 36, 2017, pages 3 - 19
KAMAL, AM. KHAMASHTA, AUTOIMMUN REV, vol. 13, 2014, pages 1094 - 1101
CANCRO, M.P.D.P. D'CRUZM.A. KHAMASHTA, J CLIN INVEST, vol. 119, 2009, pages 1066 - 73
J. BIOL. CHEM, vol. 243, 1968, pages 3558
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE
LEFRANC, M.P. ET AL., DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77
FRONT IMMUNOL, vol. 9, 16 October 2018 (2018-10-16), pages 2278
PROT. SCI., vol. 9, 2000, pages 487 - 496
YAZAKI, PWU, A.M: "Methods in Molecular Biology", vol. 248, 2004, HUMANA PRESS, pages: 255 - 268
"Antibodies: A Laboratory Manual and Molecular Cloning: A Laboratory Manual", COLD SPRING HARBOR LABORATORY
XU HAI-YAN, YONG WANG, GE-HUA YU, HONG-BING MA, YING XU, QIN SHI: "The Regulatory Role of Human TACI-Fc Fusion Protein to XG6 Cell Line in Vitro", CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY, vol. 25, no. 11, 28 November 2005 (2005-11-28), pages 912 - 916, XP055782083
TSOKOS, G.C. ET AL., NAT REV RHEUMATOL, vol. 12, 2016, pages 716 - 730
LAROSA, M. ET AL., EXPERT REV CLIN IMMUNOL, vol. 12, 2016, pages 1309 - 1320
MURPHY, G.D.A. ISENBERG, NAT REV RHEUMATOL, vol. 15, 2019, pages 403 - 412
LAM, N.C.M.V. GHETUM.L. BIENIEK, AM FAM PHYSICIAN, vol. 94, 2016, pages 284 - 294
MOSCHEN, A.R.H. TILGT. RAINE, NAT REV GASTROENTEROL HEPATOL, vol. 16, 2019, pages 185 - 196
FRIEDER, J. ET AL., CLIN PHARMACOL THER, vol. 103, 2018, pages 88 - 101
LEE, E.B. ET AL., CUTIS, vol. 101, 2018, pages 5 - 9
FLOSS, D.M. ET AL., CYTOKINE GROWTH FACTOR REV, vol. 26, 2015, pages 569 - 578
SAMY, E. ET AL., INT REV IMMUNOL, vol. 36, 2017, pages 3 - 19
KAMAL, AM. KHAMASHTA, AUTOIMMUN REV, vol. 13, 2014, pages 1094 - 1101
CANCRO, M.P.D.P. D'CRUZM.A. KHAMASHTA, J CLIN INVEST, vol. 119, 2009, pages 1066 - 73
J. BIOL. CHEM, vol. 243, 1968, pages 3558
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE
LEFRANC, M.P. ET AL., DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77
FRONT IMMUNOL, vol. 9, 16 October 2018 (2018-10-16), pages 2278
PROT. SCI., vol. 9, 2000, pages 487 - 496
YAZAKI, PWU, A.M: "Methods in Molecular Biology", vol. 248, 2004, HUMANA PRESS, pages: 255 - 268
"Antibodies: A Laboratory Manual and Molecular Cloning: A Laboratory Manual", COLD SPRING HARBOR LABORATORY
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
Download PDF: