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Title:
TUBULAR NANOFIBER MATERIAL AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/108469
Kind Code:
A1
Abstract:
Provide in the present invention is a preparation method for a tubular nanofiber material, comprising the following steps: 1) subjecting a water-soluble substance to electrostatic spinning by using an electrostatic spinning device, and collecting a tubular material 1 by using a collecting device, the collecting device comprising a cylindrical metal rod; 2) subjecting a spinning solution to electrostatic spinning by using the electrostatic spinning device, and collecting a tubular material 2 by using the collecting device in which the tubular material 1 is collected; 3) dissolving the tubular material 1 with an organic solvent, and performing collecting to obtain the tubular material 2; and 4) treating the tubular material with a crystalline material to obtain a tubular nanofiber material. The present invention provides a solution for simulating the micro-environment morphology of a vascular extracellular matrix and promoting an in-vivo induced endothelium formation by using a fiber material having a shish-kebab structure. Compared with a traditional chemical small-molecule modification mode, the physical crystallization mode used in the present patent has the advantages of the operation being simple and convenient, the structure being stable, and failure caused by the influence of an external environment being not prone to occur.

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Inventors:
PAN HAOBO (CN)
WU TONG (CN)
Application Number:
PCT/CN2021/138267
Publication Date:
June 22, 2023
Filing Date:
December 15, 2021
Export Citation:
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Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
A61L27/18; A61L27/16; A61L27/20; A61L27/50; B82Y5/00; B82Y30/00; D01D5/00; D01F6/62
Foreign References:
CN109056316A2018-12-21
CN101653624A2010-02-24
CN104998297A2015-10-28
US20120150205A12012-06-14
CN107789666A2018-03-13
CN110725017A2020-01-24
CN102764171A2012-11-07
Attorney, Agent or Firm:
BEIJING CHENGHUI LAW FIRM (CN)
Download PDF:
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