Title:
TUMOR ANTIGEN PEPTIDE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1999/029715
Kind Code:
A1
Abstract:
Tumor antigen peptide derivatives containing the whole amino acid sequence derived from the amino acid sequence Glu Tyr Arg Gly Phe Thr Gln Asp Phe (SEQ ID NO:3) by altering one to several amino acid residues or a part thereof and capable of binding to HLA-A24 antigen and thus being recognized by cytotoxic T cells; the use of these tumor antigen peptide derivatives in treating, preventing and diagnosing tumors; and remedies or preventives for tumors containing these peptide derivatives as the active ingredient.
Inventors:
ITOH KYOGO (JP)
SHICHIJO SHIGEKI (JP)
IMAI YASUHISA (JP)
SHICHIJO SHIGEKI (JP)
IMAI YASUHISA (JP)
Application Number:
PCT/JP1998/005430
Publication Date:
June 17, 1999
Filing Date:
December 02, 1998
Export Citation:
Assignee:
ITOH KYOGO (JP)
SHICHIJO SHIGEKI (JP)
IMAI YASUHISA (JP)
SHICHIJO SHIGEKI (JP)
IMAI YASUHISA (JP)
International Classes:
C07K14/47; C12N5/08; C12N15/12; A61K38/00; (IPC1-7): C07K7/06; C12N5/08; C12N15/12; A61K38/08; A61K45/05
Domestic Patent References:
| WO1997046676A1 | 1997-12-11 |
Other References:
NAKAO M, ET AL.: "HLA A2601-RESTRICTED CTLS RECOGNIZE A PEPTIDE ANTIGEN EXPRESSED ON SQUAMOUS CELL CARCINOMA", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 55, 1 October 1995 (1995-10-01), US, pages 4248 - 4252, XP002917783, ISSN: 0008-5472
YAMAZAKI Y: "CLINICAL IMMUNOLOGY", CLINICAL IMMUNOLOGY, ACADEMIC PRESS,, US, vol. 27, no. 09, 1 September 1995 (1995-09-01), US, pages 1034 - 1042, XP002917784, ISSN: 1521-6616
SHICHIJO S, ET AL.: "A GENE ENCODING ANTIGENIC PEPTIDES OF HUMAN SQUAMOUS CELL CARCINOMARECOGNIZED BY CYTOTOXIC T LYMPHOCYTES", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 187, no. 03, 1 February 1998 (1998-02-01), US, pages 277 - 288, XP002917785, ISSN: 0022-1007, DOI: 10.1084/jem.187.3.277
See also references of EP 1055684A4
YAMAZAKI Y: "CLINICAL IMMUNOLOGY", CLINICAL IMMUNOLOGY, ACADEMIC PRESS,, US, vol. 27, no. 09, 1 September 1995 (1995-09-01), US, pages 1034 - 1042, XP002917784, ISSN: 1521-6616
SHICHIJO S, ET AL.: "A GENE ENCODING ANTIGENIC PEPTIDES OF HUMAN SQUAMOUS CELL CARCINOMARECOGNIZED BY CYTOTOXIC T LYMPHOCYTES", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 187, no. 03, 1 February 1998 (1998-02-01), US, pages 277 - 288, XP002917785, ISSN: 0022-1007, DOI: 10.1084/jem.187.3.277
See also references of EP 1055684A4
Attorney, Agent or Firm:
Aoyama, Tamotsu (Shiromi 1-chome Chuo-ku, Osaka-shi Osaka, JP)
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