Title:
TUMOR ANTIGEN
Document Type and Number:
WIPO Patent Application WO/2001/011044
Kind Code:
A1
Abstract:
A tumor antigen peptide capable of inducing and/or activating HLA-A24 restraint and/or HLA-A2 restrain tumor-specific cytotoxic T cells; a polynucleotide encoding this peptide or its complementary strand; a recombinant vector containing this polynucleotide; a transformant containing this recombinant vector; a process for producing the peptide; an antibody against the peptide; a compound undergoing interactions with these substances; a method of screening the compound; medicinal compositions with the use of these substances; and a means of diagnosing by using the same.
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Inventors:
ITOH KYOGO (JP)
Application Number:
PCT/JP2000/005220
Publication Date:
February 15, 2001
Filing Date:
August 03, 2000
Export Citation:
Assignee:
ITOH KYOGO (JP)
International Classes:
A61P35/00; C12N9/12; C12N15/12; A61K38/00; A61K39/00; (IPC1-7): C12N15/12; C07K14/82; C07K7/00; A61K39/00; A61K39/395; A61K48/00; A61K45/00; A61P35/00; A61K38/10; G01N33/50; G01N33/15
Other References:
KIKUCHI M. ET AL.: "Identification of a SART-1-derived peptide of inducing HLA-A-A24-restricted and tumor-specific cytotoxic T", INT. J. CANCER, vol. 81, no. 3, May 1999 (1999-05-01), pages 459 - 466, XP002933334
KOGA Y. ET AL.: "A human T-cell-specific cDNA clone(YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases", EUR. J. IMMUNOL., vol. 16, no. 12, 1986, pages 1643 - 1646, XP002933335
TANAKA A. ET AL.: "DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes", MOL. CELL BIOL., vol. 7, no. 5, 1987, pages 1978 - 1983, XP002933336
"HLA", vol. L, 1991, OXFORD SCIENTIFIC PUBLICATIONS, pages: 1065 - 1220
J. EXP. MED., vol. 187, 1998, pages 277 - 288
NATURE, vol. 319, 1986, pages 682 - 685
EUR. J. IMMUNOL., vol. 16, 1986, pages 1643 - 1646
J. CELL. BIOCHEM., vol. 38, 1988, pages 117 - 126
GENE, vol. 84, 1989, pages 105 - 113
J. EXP. MED., vol. 187, 1998, pages 277 - 288
See also references of EP 1207199A4
KOGA Y. ET AL.: "A human T-cell-specific cDNA clone(YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases", EUR. J. IMMUNOL., vol. 16, no. 12, 1986, pages 1643 - 1646, XP002933335
TANAKA A. ET AL.: "DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes", MOL. CELL BIOL., vol. 7, no. 5, 1987, pages 1978 - 1983, XP002933336
"HLA", vol. L, 1991, OXFORD SCIENTIFIC PUBLICATIONS, pages: 1065 - 1220
J. EXP. MED., vol. 187, 1998, pages 277 - 288
NATURE, vol. 319, 1986, pages 682 - 685
EUR. J. IMMUNOL., vol. 16, 1986, pages 1643 - 1646
J. CELL. BIOCHEM., vol. 38, 1988, pages 117 - 126
GENE, vol. 84, 1989, pages 105 - 113
J. EXP. MED., vol. 187, 1998, pages 277 - 288
See also references of EP 1207199A4
Attorney, Agent or Firm:
Shoji, Takashi (Iwamotocho 3-chome Chiyoda-ku Tokyo, JP)
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