Title:
TUMOR CHEMOTHERAPY PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2022/188491
Kind Code:
A1
Abstract:
Disclosed is a tumor chemotherapy pharmaceutical composition, and specifically disclosed is the use of sildenafil as an anti-tumor drug sensitizer in the preparation of a tumor chemotherapy drug. It is found that sildenafil as a sensitizer is combined with antitumor drugs such as oxaliplatin, irinotecan or capecitabine by means of a carrier to prepare an antitumor composition, and the antitumor composition can be used for effectively killing colorectal cancer and other tumor cells or drug-resistant tumor cells. The sensitization effect of sildenafil on antitumor drugs is verified at the cellular level for the first time, the treatment synergistic effect of sildenafil as a sensitizer in colorectal cancer, gastric cancer, liver cancer, breast cancer, prostate cancer and other cancers is confirmed, and a new way and means are provided for effectively treating tumors.
Inventors:
QIN FEI (CN)
WANG JIANSONG (CN)
WANG WEI (CN)
WANG GANMI (CN)
WU JIARONG (CN)
BAO YINGXIA (CN)
WANG JIANSONG (CN)
WANG WEI (CN)
WANG GANMI (CN)
WU JIARONG (CN)
BAO YINGXIA (CN)
Application Number:
PCT/CN2021/137398
Publication Date:
September 15, 2022
Filing Date:
December 13, 2021
Export Citation:
Assignee:
GUANGZHOU BAIYUNSHAN PHARMACEUTICAL HOLDINGS CO LTD BAIYUNSHAN PHARMACEUTICAL GENERAL FACTORY (CN)
International Classes:
A61K45/06; A61K31/282; A61K31/4745; A61K31/513; A61K31/519; A61K31/555; A61K31/7068; A61K33/243; A61P35/00
Domestic Patent References:
| WO2006091542A2 | 2006-08-31 |
Foreign References:
| CN113082210A | 2021-07-09 |
Other References:
HASSANVAND FARIBA, MOHAMMADI TANNAZ, AYOUBZADEH NEGAR, TAVAKOLI ATIEH, HASSANZADEH NAIEMEH, SANIKHANI NAFISEHSADAT, AZIMI ALIIPAKC: "Sildenafil enhances cisplatin-induced apoptosis in human breast adenocarcinoma cells", JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, MEDKNOW PUBLICATIONS AND MEDIA PVT. LTD., INDIA, vol. 0, no. 0, 1 January 2020 (2020-01-01), India , pages 0, XP055965701, ISSN: 0973-1482, DOI: 10.4103/jcrt.JCRT_675_19
DOMVRI KALLIOPI, ZAROGOULIDIS KONSTANTINOS, ZIOGAS NIKOLAOS, ZAROGOULIDIS PAUL, PETANIDIS SAVVAS, PORPODIS KONSTANTINOS, KIOSEOGLO: "Potential synergistic effect of phosphodiesterase inhibitors with chemotherapy in lung cancer", JOURNAL OF CANCER, IVYSPRING INTERNATIONAL PUBLISHER, AU, vol. 8, no. 18, 1 January 2017 (2017-01-01), AU , pages 3648 - 3656, XP055965699, ISSN: 1837-9664, DOI: 10.7150/jca.21783
DENT PAUL, LAURENCE BOOTH,JANE L. ROBERTS,ANDREW POKLEPOVIC,JOHN F. HANCOCK: "(Curcumin+sildenafil) enhances the efficacy of 5FU and anti-PD1 therapies in vivo", J CELL PHYSIOL., vol. 235, no. 10, 27 January 2020 (2020-01-27), pages 6862 - 6874, XP055965697, DOI: 10.1002/jcp.29580
EL-NAA MONA, OTHMAN MOHAMED, YOUNES SHEREN: "Sildenafil potentiates the antitumor activity of cisplatin by induction of apoptosis and inhibition of proliferation and angiogenesis", DRUG DESIGN, DEVELOPMENT AND THERAPY, vol. Volume 10, 16 November 2016 (2016-11-16), pages 3661 - 3672, XP055965692, DOI: 10.2147/DDDT.S107490
LI QING, SHU YAN: "Pharmacological Modulation of Cytotoxicity and Cellular Uptake of Anti-cancer Drugs by PDE5 Inhibitors in Lung Cancer Cells", PHARMACEUTICAL RESEARCH, SPRINGER US, NEW YORK, vol. 31, no. 1, 1 January 2014 (2014-01-01), New York, pages 86 - 96, XP055965689, ISSN: 0724-8741, DOI: 10.1007/s11095-013-1134-0
BOOTH LAURENCE, ROBERTS JANE L., CRUICKSHANKS NICHOLA, CONLEY ADAM, DURRANT DAVID E., DAS ANINDITA, FISHER PAUL B., KUKREJA RAKESH: "Phosphodiesterase 5 Inhibitors Enhance Chemotherapy Killing in Gastrointestinal/Genitourinary Cancer Cells", MOLECULAR PHARMACOLOGY, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 85, no. 3, 1 March 2014 (2014-03-01), US , pages 408 - 419, XP055965687, ISSN: 0026-895X, DOI: 10.1124/mol.113.090043
DOMVRI KALLIOPI, ZAROGOULIDIS KONSTANTINOS, ZIOGAS NIKOLAOS, ZAROGOULIDIS PAUL, PETANIDIS SAVVAS, PORPODIS KONSTANTINOS, KIOSEOGLO: "Potential synergistic effect of phosphodiesterase inhibitors with chemotherapy in lung cancer", JOURNAL OF CANCER, IVYSPRING INTERNATIONAL PUBLISHER, AU, vol. 8, no. 18, 1 January 2017 (2017-01-01), AU , pages 3648 - 3656, XP055965699, ISSN: 1837-9664, DOI: 10.7150/jca.21783
DENT PAUL, LAURENCE BOOTH,JANE L. ROBERTS,ANDREW POKLEPOVIC,JOHN F. HANCOCK: "(Curcumin+sildenafil) enhances the efficacy of 5FU and anti-PD1 therapies in vivo", J CELL PHYSIOL., vol. 235, no. 10, 27 January 2020 (2020-01-27), pages 6862 - 6874, XP055965697, DOI: 10.1002/jcp.29580
EL-NAA MONA, OTHMAN MOHAMED, YOUNES SHEREN: "Sildenafil potentiates the antitumor activity of cisplatin by induction of apoptosis and inhibition of proliferation and angiogenesis", DRUG DESIGN, DEVELOPMENT AND THERAPY, vol. Volume 10, 16 November 2016 (2016-11-16), pages 3661 - 3672, XP055965692, DOI: 10.2147/DDDT.S107490
LI QING, SHU YAN: "Pharmacological Modulation of Cytotoxicity and Cellular Uptake of Anti-cancer Drugs by PDE5 Inhibitors in Lung Cancer Cells", PHARMACEUTICAL RESEARCH, SPRINGER US, NEW YORK, vol. 31, no. 1, 1 January 2014 (2014-01-01), New York, pages 86 - 96, XP055965689, ISSN: 0724-8741, DOI: 10.1007/s11095-013-1134-0
BOOTH LAURENCE, ROBERTS JANE L., CRUICKSHANKS NICHOLA, CONLEY ADAM, DURRANT DAVID E., DAS ANINDITA, FISHER PAUL B., KUKREJA RAKESH: "Phosphodiesterase 5 Inhibitors Enhance Chemotherapy Killing in Gastrointestinal/Genitourinary Cancer Cells", MOLECULAR PHARMACOLOGY, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 85, no. 3, 1 March 2014 (2014-03-01), US , pages 408 - 419, XP055965687, ISSN: 0026-895X, DOI: 10.1124/mol.113.090043
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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