Title:
TUMOR MICROENVIRONMENT-ACTIVATED CYTOKINE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/017219
Kind Code:
A1
Abstract:
Disclosed are a tumor microenvironment-activated cytokine IFN-α and use thereof. After cysteine mutation of IFN-α, IFN-α is joined to a substrate and a mask body that can be recognized and cleaved by substances highly expressed by tumors to form a biomolecular conjugate. The INF-α activity of the biomolecular conjugate in normal tissues is hindered, not causing toxicity to normal tissues. The INF-α activity is activated for effective tumor inhibition in tumor environments.
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Inventors:
ZHANG RUI (CN)
CHEN TAO (CN)
LIU YUAN (CN)
LIU CHEN (CN)
CHEN TAO (CN)
LIU YUAN (CN)
LIU CHEN (CN)
Application Number:
PCT/CN2023/107809
Publication Date:
January 25, 2024
Filing Date:
July 18, 2023
Export Citation:
Assignee:
YAFEI SHANGHAI BIOLOGY MEDICINE SCIENCE & TECH CO LTD (CN)
International Classes:
A61K38/19; A61K47/60; A61K47/64; A61P35/00
Foreign References:
| CN111670051A | 2020-09-15 | |||
| CN1738640A | 2006-02-22 | |||
| CN101247821A | 2008-08-20 | |||
| US20190151462A1 | 2019-05-23 | |||
| US20200247842A1 | 2020-08-06 |
Other References:
ZHANG ZHEN-TAO; HUANG-FU MING-YI; XU WEN-HONG; HAN MIN: "Stimulus-responsive nanoscale delivery systems triggered by the enzymes in the tumor microenvironment", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM., NL, vol. 137, 1 January 1900 (1900-01-01), NL , pages 122 - 130, XP085632740, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2019.02.009
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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