Title:
TWIN DRUG-TYPE HMG-COA REDUCTASE INHIBITOR AND SYNTHESIS METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/233595
Kind Code:
A1
Abstract:
Disclosed is a twin drug-type HMG-CoA reductase inhibitor, which is a twin drug formed by chain linking a fibrate compound, selected from any one of gemfibrozil, clofibric acid, fenofibrate acid, bezafibrate or ciprofibrate, or nicotinic acid or acipimox and a statin by a linker Br-(CH2)n-Br, Br-(CH2)n-OH or Br-(CH2)n-NH2, wherein n is an integer from 1 to 30, and the statin is mevastatin, lovastatin, simvastatin, pravastatin, fluvastatin, cerivastatin, atorvastatin, rosuvastatin or pitavastatin.
Inventors:
WU FANHONG (CN)
HUANG JINWEN (CN)
LIU YECHENG (CN)
SUO QI (CN)
WU YUELIN (CN)
LI YUANMEI (CN)
LI DANDAN (CN)
HUANG JINWEN (CN)
LIU YECHENG (CN)
SUO QI (CN)
WU YUELIN (CN)
LI YUANMEI (CN)
LI DANDAN (CN)
Application Number:
PCT/CN2018/091800
Publication Date:
December 27, 2018
Filing Date:
June 19, 2018
Export Citation:
Assignee:
SHANGHAI INST TECH (CN)
International Classes:
A61K31/405; A61K31/455; C07D209/24; C07D401/12; A61P3/06
Domestic Patent References:
| WO2014111957A1 | 2014-07-24 |
Foreign References:
| CN107224436A | 2017-10-03 | |||
| CN103232348A | 2013-08-07 | |||
| CN101854912A | 2010-10-06 | |||
| CN104546854A | 2015-04-29 |
Attorney, Agent or Firm:
SHANGHAI HANGSOME INTELLECTUAL PROPERTY LTD (CN)
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