Title:
TWO PROSTATE-SPECIFIC MEMBRANE ANTIGEN-TARGETING FLUORESCENT PROBES, METHOD FOR PREPARING SAME AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/087169
Kind Code:
A1
Abstract:
Provided are two prostate-specific membrane antigen-targeting fluorescent probes, a method for preparing same and the application thereof. The probes have a good affinity and specificity to prostate cancer cells which express a PSMA. In small-animal in vivo imaging, fluorescence signals can be increased, background signals can be reduced, and a good stability, time resolution and spatial resolution are achieved within a certain time. New specific prostate cancer targeting fluorescent probe molecules are designed and synthesized, thereby greatly improving the specificity and sensitivity of prostate cancer detection; same can be used for testing a prostate cancer clinical sample; and high-precision and high-sensitivity real-time imaging navigation is also provided for an individualized accurate surgery, thereby realizing accurate prostate cancer diagnosis and treatment.
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Inventors:
XING NIANZENG (CN)
HU HAI-YU (CN)
WU LING-LING (CN)
ZHAO QINXIN (CN)
WANG QINGHUA (CN)
ZHANG QINGYANG (CN)
HU HAI-YU (CN)
WU LING-LING (CN)
ZHAO QINXIN (CN)
WANG QINGHUA (CN)
ZHANG QINGYANG (CN)
Application Number:
PCT/CN2021/131122
Publication Date:
May 25, 2023
Filing Date:
November 17, 2021
Export Citation:
Assignee:
CANCER HOSPITAL CAMS (CN)
INST MATERIA MEDICA CAMS (CN)
INST MATERIA MEDICA CAMS (CN)
International Classes:
C07D209/10; C09K11/06; G01N21/64
Domestic Patent References:
| WO2021002771A1 | 2021-01-07 |
Foreign References:
| CN108135903A | 2018-06-08 | |||
| CN110199195A | 2019-09-03 | |||
| US20190151480A1 | 2019-05-23 | |||
| CN112062695A | 2020-12-11 | |||
| CN112341474A | 2021-02-09 | |||
| CN112675311A | 2021-04-20 | |||
| CN113117099A | 2021-07-16 | |||
| CN112694431A | 2021-04-23 | |||
| US20130122502A1 | 2013-05-16 |
Other References:
LIU, T. ; WU, L.Y. ; HOPKINS, M.R. ; CHOI, J.K. ; BERKMAN, C.E.: "A targeted low molecular weight near-infrared fluorescent probe for prostate cancer", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 20, no. 23, 1 December 2010 (2010-12-01), Amsterdam NL , pages 7124 - 7126, XP027459371, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2010.09.057
Attorney, Agent or Firm:
JEEKAI&PARTNERS (CN)
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