Title:
TWO-REACTANT SHEET-FORM TISSUE-ADHESIVE-REINFORCING MATERIAL
Document Type and Number:
WIPO Patent Application WO/2020/122007
Kind Code:
A1
Abstract:
The present invention provides a sheet-form tissue-reinforcing material and a method for producing the same, wherein the sheet-form tissue-reinforcing material is configured as follows in order to achieve an excellent tissue-reinforcing effect and excellent handling properties without needing to use fibrinogen or clotting performance derived from a patient. This sheet-form tissue-reinforcing material includes a base-material sheet that is biodegradable and has a communicated porous structure, and an adhesive agent resin layer formed by being secured on the base-material sheet. The adhesive agent resin layer includes a first reactant including aldehydated glycan, and a second reactant including partial carboxylated polylysine, and has: a granular structure derived from a powder of the first reactant; and a connection layer derived from the second reactant, the connection layer being anchored to the base-material sheet and being mutually connected to the granular structure. A mixed powder of a two-reactant adhesive agent comprising the powder of the first reactant and a powder of the second reactant is used in order to produce the sheet-form tissue-reinforcing material. For example, the mixed powder is dispersed in ethanol having a water content of less than 1%, and a dispersion liquid thereof is applied to the base-material sheet and then dried.
Inventors:
TANIDA SHUHEI (JP)
FUJIMURA MOTOKI (JP)
KOJITANI YUSUKE (JP)
OSADA SHINICHI (JP)
HYON WOOGI (JP)
HYON SUONG-HYU (JP)
FUJIMURA MOTOKI (JP)
KOJITANI YUSUKE (JP)
OSADA SHINICHI (JP)
HYON WOOGI (JP)
HYON SUONG-HYU (JP)
Application Number:
PCT/JP2019/048068
Publication Date:
June 18, 2020
Filing Date:
December 09, 2019
Export Citation:
Assignee:
BMG INCORPORATED (JP)
International Classes:
A61L15/26; B32B27/00; A61L15/28; A61L15/32; A61L15/42; A61L15/44; A61L15/58; A61L15/64; C08G81/00
Domestic Patent References:
| WO2008066182A1 | 2008-06-05 | |||
| WO2006080523A1 | 2006-08-03 | |||
| WO2008066182A1 | 2008-06-05 | |||
| WO2012029971A1 | 2012-03-08 |
Foreign References:
| JP2014518250A | 2014-07-28 | |||
| JP2016063919A | 2016-04-28 | |||
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Other References:
HYON, SUONG-HYU: "Medical Adhesive using the Food Additives", JOURNAL OF THE ADHESION SOCIETY OF JAPAN, vol. 49, no. 8, 1 August 2013 (2013-08-01), pages 293 - 304, XP009522152, ISSN: 0916-4812, DOI: 10.11618/adhesion.49.293
J. THORACICCARDIOVASCULAR SURGERY, DEVELOPMENT OF NEW BIODEGRADABLE HYDROGEL GLUE FOR PREVENTING ALVEOLAR AIR LEAKAGE, vol. 134, no. 5, November 2007 (2007-11-01), pages 1241 - 8
See also references of EP 3895890A4
J. THORACICCARDIOVASCULAR SURGERY, DEVELOPMENT OF NEW BIODEGRADABLE HYDROGEL GLUE FOR PREVENTING ALVEOLAR AIR LEAKAGE, vol. 134, no. 5, November 2007 (2007-11-01), pages 1241 - 8
See also references of EP 3895890A4
Attorney, Agent or Firm:
YAMASHITA, Takuji et al. (JP)
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