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Title:
TWO-STAGE HUNDRED-MICROSECOND PULSE FOCUSED ULTRASOUND TISSUE DESTRUCTION METHOD
Document Type and Number:
WIPO Patent Application WO/2018/018725
Kind Code:
A1
Abstract:
A two-stage hundred-microsecond pulse focused ultrasound tissue destruction method, comprising: 1) positioning a target tissue of a sample (9) by using a monitoring guidance system, and adjusting a position of the target tissue to a focal point of an HIFU transducer (5); 2) a first stage destruction: forming loose local tissue structures by means of a shock wave excited by a hundred-microsecond pulse focused ultrasound, as well as boiling air bubbles and inertial cavitation generated thereby; 3) a second stage destruction: further mechanically crushing and homogenizing the tissues in a damaged area by means of a pulse focused ultrasound having a hundred-microsecond length, so as to achieve tissue destruction. The method takes full advantage of the following features: a pulse having a relatively high duty cycle exhibits both thermal and mechanical effects, while a pulse having a low duty cycle exhibits good mechanical effects. By controlling a high-intensity ultrasound sequence in which two stages are generated consecutively, a single pulse of which lasts one hundred microseconds, and which has a pulse having a relatively high duty cycle and a low duty ratio to act on a target tissue, highly efficient tissue destruction may be achieved.

Inventors:
LU MINGZHU (CN)
WANG RUI (CN)
GUAN YUBO (CN)
LI YUJIAO (CN)
HUANG WEIJUN (CN)
MA FENGCHAO (CN)
ZHANG LINGLU (CN)
WAN MINGXI (CN)
Application Number:
PCT/CN2016/099266
Publication Date:
February 01, 2018
Filing Date:
September 19, 2016
Export Citation:
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Assignee:
XI'AN JIAOTONG UNIV (CN)
International Classes:
A61N7/02
Domestic Patent References:
WO2015148966A12015-10-01
Foreign References:
CN104225810A2014-12-24
CN1803225A2006-07-19
US6309355B12001-10-30
US20110251528A12011-10-13
Other References:
GUAN, YUBO ET AL.: "Histotripsy produced by hundreds of microsecond focused ultrasound pulses in gels and tissue ex vivo", 2015 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM PROCEEDINGS, vol. 240, 24 October 2015 (2015-10-24), pages 1 - 4, XP032799374, DOI: 10.1109/ULTSYM.2015.0508
GUAN, YUBO ET AL.: "Histotripsy produced by hundred-microsecond-long focused ultrasonic pulses:a preliminary study", ULTRASOUND IN MEDICINE AND BIOLOGY, vol. 42, 16 June 2016 (2016-06-16), pages 9, XP029682952, ISSN: 0301-5629, DOI: doi:10.1016/j.ultrasmedbio.2016.01.022
Attorney, Agent or Firm:
XI'AN TONG DA PATENT AGENCY CO., LTD. (CN)
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