Title:
TWO-STAGE HUNDRED-MICROSECOND PULSE FOCUSED ULTRASOUND TISSUE DESTRUCTION METHOD
Document Type and Number:
WIPO Patent Application WO/2018/018725
Kind Code:
A1
Abstract:
A two-stage hundred-microsecond pulse focused ultrasound tissue destruction method, comprising: 1) positioning a target tissue of a sample (9) by using a monitoring guidance system, and adjusting a position of the target tissue to a focal point of an HIFU transducer (5); 2) a first stage destruction: forming loose local tissue structures by means of a shock wave excited by a hundred-microsecond pulse focused ultrasound, as well as boiling air bubbles and inertial cavitation generated thereby; 3) a second stage destruction: further mechanically crushing and homogenizing the tissues in a damaged area by means of a pulse focused ultrasound having a hundred-microsecond length, so as to achieve tissue destruction. The method takes full advantage of the following features: a pulse having a relatively high duty cycle exhibits both thermal and mechanical effects, while a pulse having a low duty cycle exhibits good mechanical effects. By controlling a high-intensity ultrasound sequence in which two stages are generated consecutively, a single pulse of which lasts one hundred microseconds, and which has a pulse having a relatively high duty cycle and a low duty ratio to act on a target tissue, highly efficient tissue destruction may be achieved.
Inventors:
LU MINGZHU (CN)
WANG RUI (CN)
GUAN YUBO (CN)
LI YUJIAO (CN)
HUANG WEIJUN (CN)
MA FENGCHAO (CN)
ZHANG LINGLU (CN)
WAN MINGXI (CN)
WANG RUI (CN)
GUAN YUBO (CN)
LI YUJIAO (CN)
HUANG WEIJUN (CN)
MA FENGCHAO (CN)
ZHANG LINGLU (CN)
WAN MINGXI (CN)
Application Number:
PCT/CN2016/099266
Publication Date:
February 01, 2018
Filing Date:
September 19, 2016
Export Citation:
Assignee:
UNIV XIAN JIAOTONG (CN)
International Classes:
A61N7/02
Domestic Patent References:
| WO2015148966A1 | 2015-10-01 |
Foreign References:
| CN104225810A | 2014-12-24 | |||
| CN1803225A | 2006-07-19 | |||
| US6309355B1 | 2001-10-30 | |||
| US20110251528A1 | 2011-10-13 |
Other References:
GUAN, YUBO ET AL.: "Histotripsy produced by hundreds of microsecond focused ultrasound pulses in gels and tissue ex vivo", 2015 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM PROCEEDINGS, vol. 240, 24 October 2015 (2015-10-24), pages 1 - 4, XP032799374, DOI: 10.1109/ULTSYM.2015.0508
GUAN, YUBO ET AL.: "Histotripsy produced by hundred-microsecond-long focused ultrasonic pulses:a preliminary study", ULTRASOUND IN MEDICINE AND BIOLOGY, vol. 42, 16 June 2016 (2016-06-16), pages 9, XP029682952, ISSN: 0301-5629, DOI: doi:10.1016/j.ultrasmedbio.2016.01.022
GUAN, YUBO ET AL.: "Histotripsy produced by hundred-microsecond-long focused ultrasonic pulses:a preliminary study", ULTRASOUND IN MEDICINE AND BIOLOGY, vol. 42, 16 June 2016 (2016-06-16), pages 9, XP029682952, ISSN: 0301-5629, DOI: doi:10.1016/j.ultrasmedbio.2016.01.022
Attorney, Agent or Firm:
XI'AN TONG DA PATENT AGENCY CO., LTD. (CN)
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