Title:
TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/109120
Kind Code:
A1
Abstract:
TYK2 inhibitors, pharmaceutical compositions of these compounds,methods of preparation and the use thereof against various TYK2-mediated diseases and disorders.
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Inventors:
WAN ZHAOKUI (CN)
LI XIAODONG (CN)
VAZQUEZ MICHAEL LAWRENCE (CN)
LI XIAODONG (CN)
VAZQUEZ MICHAEL LAWRENCE (CN)
Application Number:
PCT/CN2022/106876
Publication Date:
June 22, 2023
Filing Date:
July 20, 2022
Export Citation:
Assignee:
LYNK PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D403/12; A61K31/501; A61P1/00; A61P19/02; A61P29/00; A61P37/06; C07D401/12; C07D401/14; C07D405/12; C07D409/14; C07D417/14
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Other References:
VARAļ¼BRANDON A. ET AL.: "Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds", ACS MEDICINAL CHEMISTRY LETTERS, vol. 12, 19 March 2021 (2021-03-19), pages 653 - 661, XP055938211, DOI: 10.1021/acsmedchemlett.1c00096
DATABASE Registry CAS; 6 July 2021 (2021-07-06), ANONYMOUS : "1,2,4-Triazine-6-carboxa mide, 5-[(1-ethyl-1Hindazol-5-yl)amino]- 3-[(3S)-3- piperidinylamino]-", XP093072980, retrieved from STN Database accession no. 2649656-47-1
DATABASE Registry CAS; 6 July 2021 (2021-07-06), ANONYMOUS : "1,2,4-Triazine-6-carboxa mide, 5-[(1-ethyl-1Hindazol-5-yl)amino]- 3-[(3S)-3- piperidinylamino]-", XP093072980, retrieved from STN Database accession no. 2649656-47-1
Attorney, Agent or Firm:
LIFANG & PARTNERS (CN)
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