TYLOSIN DERIVATIVES,PROCESSES FOR THEIR PREPARATION,AND NOVEL PROCESSES INVOLVING TYLOSIN DERIVATIVES

Title:

TYLOSIN DERIVATIVES,PROCESSES FOR THEIR PREPARATION,AND NOVEL PROCESSES INVOLVING TYLOSIN DERIVATIVES

Document Type and Number:

WIPO Patent Application WO1987003880

Kind Code:

A3

Abstract:

There are disclosed novel di- and tri-O-acetyl-23-O-demycinosyl-4"-O-iso-valeryltylosins and the pharmaceutically acceptable salts thereof, which have improved activity as antibacterials and provide higher blood levels than other tylosin derived compounds. These compounds have the following structural formulawherein R is acetyl or hydrogen and Z is for example O orProcesses for selectively deacylating the 2'-and 4"-positions of 3,2',4",4"'-tetra-O-acyltylosin or 2',4",4'"-tri-O-acyltylosin and for the selective acylation of 2',4"-di-O-acyltylosin and 2',4",4"'-tri-O-acyltylosin are also disclosed

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Inventors:

MALLAMS ALAN K (US)
ROSSMAN RANDALL R (US)

Application Number:

PCT/US1986/002696

Publication Date:

April 21, 1988

Filing Date:

December 19, 1986

Export Citation:

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Assignee:

SCHERING CORP (US)

International Classes:

C07H17/08; (IPC1-7): C07H17/08; A61K31/70

Foreign References:

EP0096900A1	1983-12-28
EP0097925A1	1984-01-11
US4435388A	1984-03-06

Other References:

CHEMICAL ABSTRACTS, Volume 105, No. 25, 22 December 1986, (Columbus, Ohio, US), see pages 854-855, Abstract 227234q, & JP-A-61 143 394 (Sanraku Co., Ltd) 1 July 1986

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