Title:
TYROSINE-DNA PHOSPHODIESTERASES (TDP) AND RELATED POLYPEPTIDES, NUCLEIC ACIDS, VECTORS, TDP-PRODUCING HOST CELLS, ANTIBODIES AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2001025407
Kind Code:
A3
Abstract:
The present invention provides a nucleic acid molecule encoding a tyrosine-DNA phosphodiesterase (TDP), and a related vector, host cell, polypeptide, antibody, antisense nucleic acid molecule, and ribozyme. Also provided are a method of altering the level of TDP in a cell, tissue, organ or organism, as well as the resulting cell, tissue, organ or non-human organism, as well as a method of identifying a TDP-resistant compound, a method of assessing TDP1 activity in an animal, and a method of assessing the efficacy of a topoisomerase I inhibitor.
Inventors:
POULIOT JEFFREY (US)
NASH HOWARD A (US)
NASH HOWARD A (US)
Application Number:
PCT/US2000/027400
Publication Date:
November 29, 2001
Filing Date:
October 05, 2000
Export Citation:
Assignee:
US HEALTH (US)
POULIOT JEFFREY (US)
NASH HOWARD A (US)
POULIOT JEFFREY (US)
NASH HOWARD A (US)
International Classes:
C12N9/16; (IPC1-7): C07K14/52; C07K14/47; C12N9/14; C12N15/09
Domestic Patent References:
| WO1992018541A1 | 1992-10-29 | |||
| WO1997015676A2 | 1997-05-01 |
Other References:
DATABASE EMBL 13 September 1999 (1999-09-13), STRAUSBERB ROBERT, XP002161091
DATABASE EMBL 6 September 1994 (1994-09-06), DUBOIS E.: "S.cerevisiae chromosome II reading frame ORF YBR223c", XP002161092
DATABASE SWALL SWALL:Q19973; 1 November 1996 (1996-11-01), WILSON R.: "Caenorhabditis elegans", XP002161093
YANG SHU-WEI ET AL: "A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 93, no. 21, 1996, 1996, pages 11534 - 11539, XP000942086, ISSN: 0027-8424
ABOUSSEKHRA A ET AL: "A NOVEL ROLE FOR THE BUDDING YEAST RAD9 CHECKPOINT GENE IN DNA DAMAGE-DEPENDENT TRANSCRIPTION", EMBO JOURNAL,OXFORD UNIVERSITY PRESS, SURREY,GB, vol. 15, no. 15, 1996, pages 3912 - 3922, XP000942139, ISSN: 0261-4189
MEGONIGAL M D ET AL: "ALTERATIONS IN THE CATALYTIC ACTIVITY OF YEAST DNA TOPOISOMERASE I RESULT IN CELL CYCLE ARREST AND CELL DEATH", JOURNAL OF BIOLOGICAL CHEMISTRY,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD,US, vol. 272, no. 19, 9 May 1997 (1997-05-09), pages 12801 - 12808, XP000942084, ISSN: 0021-9258
FELDMANN H ET AL: "COMPLETE DNA SEQUENCE OF YEAST CHROMOSOME II", EMBO JOURNAL,OXFORD UNIVERSITY PRESS, SURREY,GB, vol. 13, no. 24, 15 December 1994 (1994-12-15), pages 5795 - 5809, XP000942152, ISSN: 0261-4189
KNAB A M ET AL: "MECHANISMS OF CAMPTOTHECIN RESISTANCE IN YEAST DNA TOPOISOMERASE I MUTANTS*", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 268, no. 30, 25 October 1993 (1993-10-25), pages 22322 - 22330, XP000567890, ISSN: 0021-9258
WANG JAMES C: "DNA topoisomerases.", ANNUAL REVIEW OF BIOCHEMISTRY, vol. 65, 1996, 1996 Annual Reviews Inc. P.O. Box 10139, 4139 El Camino Way, Palo Alto, California 94306, USA, pages 635 - 692, XP002161090, ISBN: 0-8243-0865-4
WILSON R ET AL: "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans", NATURE,MACMILLAN JOURNALS LTD. LONDON,GB, vol. 368, 3 March 1994 (1994-03-03), pages 32 - 38, XP002119914, ISSN: 0028-0836
POULIOT J J ET AL: "YEAST GENE FOR A TYR-DNA PHOSPHODIESTERASE THAT REPAIRS TOPOISOMERASE I COMPLEXES", NATURE,MACMILLAN JOURNALS LTD. LONDON,GB, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 552 - 555, XP000941785, ISSN: 0028-0836
DATABASE EMBL 6 September 1994 (1994-09-06), DUBOIS E.: "S.cerevisiae chromosome II reading frame ORF YBR223c", XP002161092
DATABASE SWALL SWALL:Q19973; 1 November 1996 (1996-11-01), WILSON R.: "Caenorhabditis elegans", XP002161093
YANG SHU-WEI ET AL: "A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 93, no. 21, 1996, 1996, pages 11534 - 11539, XP000942086, ISSN: 0027-8424
ABOUSSEKHRA A ET AL: "A NOVEL ROLE FOR THE BUDDING YEAST RAD9 CHECKPOINT GENE IN DNA DAMAGE-DEPENDENT TRANSCRIPTION", EMBO JOURNAL,OXFORD UNIVERSITY PRESS, SURREY,GB, vol. 15, no. 15, 1996, pages 3912 - 3922, XP000942139, ISSN: 0261-4189
MEGONIGAL M D ET AL: "ALTERATIONS IN THE CATALYTIC ACTIVITY OF YEAST DNA TOPOISOMERASE I RESULT IN CELL CYCLE ARREST AND CELL DEATH", JOURNAL OF BIOLOGICAL CHEMISTRY,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD,US, vol. 272, no. 19, 9 May 1997 (1997-05-09), pages 12801 - 12808, XP000942084, ISSN: 0021-9258
FELDMANN H ET AL: "COMPLETE DNA SEQUENCE OF YEAST CHROMOSOME II", EMBO JOURNAL,OXFORD UNIVERSITY PRESS, SURREY,GB, vol. 13, no. 24, 15 December 1994 (1994-12-15), pages 5795 - 5809, XP000942152, ISSN: 0261-4189
KNAB A M ET AL: "MECHANISMS OF CAMPTOTHECIN RESISTANCE IN YEAST DNA TOPOISOMERASE I MUTANTS*", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 268, no. 30, 25 October 1993 (1993-10-25), pages 22322 - 22330, XP000567890, ISSN: 0021-9258
WANG JAMES C: "DNA topoisomerases.", ANNUAL REVIEW OF BIOCHEMISTRY, vol. 65, 1996, 1996 Annual Reviews Inc. P.O. Box 10139, 4139 El Camino Way, Palo Alto, California 94306, USA, pages 635 - 692, XP002161090, ISBN: 0-8243-0865-4
WILSON R ET AL: "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans", NATURE,MACMILLAN JOURNALS LTD. LONDON,GB, vol. 368, 3 March 1994 (1994-03-03), pages 32 - 38, XP002119914, ISSN: 0028-0836
POULIOT J J ET AL: "YEAST GENE FOR A TYR-DNA PHOSPHODIESTERASE THAT REPAIRS TOPOISOMERASE I COMPLEXES", NATURE,MACMILLAN JOURNALS LTD. LONDON,GB, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 552 - 555, XP000941785, ISSN: 0028-0836
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