Title:
ULTRASENSITIVE BIOCHEMICAL SENSING PLATFORM
Document Type and Number:
WIPO Patent Application WO2005043160
Kind Code:
A3
Abstract:
An electronic sensor is provided for detecting the presence of one or more targets of interest in a sample. The sensor preferably comprises a special type of field effect transistor in which conductance is enhanced by target binding to recognition elements in the active region 280. An array of sensors may be formed to analyze a sample for multiple targets. The sensor may be used, for example, to detect the presence of pathogens, polypeptides, nucleic acids, toxins and other biochemical and chemical agents. The sensor is useful in a wide variety of applications including medical diagnostics, agriculture, public health, environmental monitoring and biomedical research.
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Inventors:
HOLM-KENNEDY JAMES (US)
Application Number:
PCT/US2004/035920
Publication Date:
June 30, 2005
Filing Date:
October 29, 2004
Export Citation:
Assignee:
UNIV HAWAII (US)
HOLM-KENNEDY JAMES (US)
HOLM-KENNEDY JAMES (US)
International Classes:
C12M1/40; C12N9/00; C12Q1/68; G01N27/414; G01N33/543; (IPC1-7): G01N33/543; C12Q1/68; G01N27/414
Domestic Patent References:
| WO1997039145A1 | 1997-10-23 | |||
| WO2002001647A1 | 2002-01-03 | |||
| WO2003062811A1 | 2003-07-31 | |||
| WO2004044586A1 | 2004-05-27 | |||
| WO2003014722A1 | 2003-02-20 | |||
| WO2002041402A2 | 2002-05-23 |
Foreign References:
| US20020006632A1 | 2002-01-17 | |||
| EP1464953A1 | 2004-10-06 |
Other References:
BESSELINK G A J ET AL: "Modification of ISFETs with a monolayer of latex beads for specific detection of proteins.", BIOSENSORS AND BIOELECTRONICS, vol. 18, no. 9, 15 August 2003 (2003-08-15), pages 1109 - 1114, XP002328132, ISSN: 0956-5663
MARTINOIA S ET AL: "Development of ISFET array-based microsystems for bioelectrochemical measurements of cell populations", BIOSENSORS & BIOELECTRONICS, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 16, no. 9-12, December 2001 (2001-12-01), pages 1043 - 1050, XP002269304, ISSN: 0956-5663
MARTINOIA S ET AL: "Development of ISFET array-based microsystems for bioelectrochemical measurements of cell populations", BIOSENSORS & BIOELECTRONICS, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 16, no. 9-12, December 2001 (2001-12-01), pages 1043 - 1050, XP002269304, ISSN: 0956-5663
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