Title:
ULTRASOUND ARRAYS FOR ENHANCED SONODYNAMIC THERAPY FOR TREATING CANCER
Document Type and Number:
WIPO Patent Application WO/2022/032283
Kind Code:
A3
Abstract:
Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.
Inventors:
AGARWAL VIJAY (US)
ELIASON BRADEN (US)
LING JEREMY (US)
BALLARD JOHN (US)
MILLER GREGG (US)
ELIASON BRADEN (US)
LING JEREMY (US)
BALLARD JOHN (US)
MILLER GREGG (US)
Application Number:
PCT/US2021/071101
Publication Date:
April 07, 2022
Filing Date:
August 04, 2021
Export Citation:
Assignee:
ALPHEUS MEDICAL INC (US)
International Classes:
A61F7/02; A61K41/00
Foreign References:
| US20120065494A1 | 2012-03-15 | |||
| US20070112344A1 | 2007-05-17 | |||
| US20200197659A1 | 2020-06-25 |
Attorney, Agent or Firm:
CHRISTENSEN, Michael, R. (US)
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