UNCONSTRAINED GENOME TARGETING WITH NEAR-PAMLESS ENGINEERED CRISPR-CAS9 VARIANTS

Title:

UNCONSTRAINED GENOME TARGETING WITH NEAR-PAMLESS ENGINEERED CRISPR-CAS9 VARIANTS

Document Type and Number:

WIPO Patent Application WO/2021/151073

Kind Code:

A3

Abstract:

Streptococcus pyogenes Cas9 (SpCas9) variants with relaxed PAM requirements capable of high-resolution editing for various applications, and methods of use thereof.

Inventors:

KLEINSTIVER BENJAMIN (US)
WALTON RUSSELL T (US)

Application Number:

PCT/US2021/014900

Publication Date:

August 26, 2021

Filing Date:

January 25, 2021

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Assignee:

MASSACHUSETTS GEN HOSPITAL (US)

International Classes:

C12N9/22; C12N9/16; C12N15/90

Foreign References:

US20180282714A1	2018-10-04
US20140315985A1	2014-10-23
US20190106687A1	2019-04-11

Attorney, Agent or Firm:

DEYOUNG, Janice Kugler et al. (US)

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