Cross-Reference to Related Applications

This application claims the benefit of United States Provisional patent application no. 63/068,813 and Canadian patent application no. 3,090,721, both of which were filed on August 21, 2020 and both entitled "UnderwearforDispensingCBD", and both of these prior patent applications are incorporated herein by reference.

Field

This application re lates to arti cl esfor applying topical therapeutic substances to skin; in particular, this application relates to articles for applying topical therapeutic substances to skin located in the user's pelvic, pubic, genital, perineum, and/or anal areas and the like.

Background

The topical application of different substances, including but not limited to vitamins, oils, hormones and drugs, to the human skin for treatment of different types of health issues, or for the enhancement of the human skin, is known in the art. However, there are particular chal lenges posed by the application of such substances, herein after referred to as "therapeutic substances,"toa person's genital, pelvic, pubic, perineum and/or anal areas. Firstly, becausesuch therapeutic substances are often in a liquid form, it is challeng ing to keep the therapeutic substances on the desired areas of one's skin without having the therapeutic substance absorb through the person's undergarments and, potentially, leak through the person's outer clothing, such as pants or a skirt. Should such therapeutic substances leak through a person's outer clothing, this may cause unsightly stains on the outer clothing. Furthermore, the absorption of the therapeutic substances into the person's clothing draws the therapeutic substances away from the targeted skin area, potentially reducingthe effectiveness of the desired treatment.

Additionally, simply applying such therapeutic substances, in liquid form, to a person's genital, pelvic, pubic per ineum and/or anal areas may cause discomfort as the person engages in dai ly activities, because such application may cause the person to feel a wet and unpleasant sensation in the areas where the therapeutic substance has been applied. As well, if effective therapeutic treatment of the person's skin requires consistent contact of the therapeutic substance on the person's skin, it may be difficult for the person to constantly re-apply fresh coatings of the therapeutic substance to their genital, pelvic, pubic, perineum and/or anal areas as the person engages in their daily activities, as such re-application may require the person to seek out a private location to engage in the re-application, away from public view.

In the prior art, of which the applicants are aware, in United States patent application no. 16/994,081 by inventor Blasius, there is disclosed an absorbent article includ ing a center portion for absorb ing fluid. The center portion, side portion, adhesive portion or any combinations thereof comprise hemp. The absorbent article may also include a water-dispersible and/or biodegradable polymer or a biopolymer; examples of biopolymers may include hemp, sugar cane, microorganisms, cel lulose, starch, and any other polymeric material including polylactic acid, polyhydroxyalkanoate, polybutylene succinate, polyhydroxybutyrate, and polybutylene terephthalate. Natural oils may be extracted from a plant and applied to the absorbent article to alleviate or relieve pains, aches, cramps related to menstruation, includingoil produced or extracted from the plant Cannabis sativa. Additionally, the absorbent article may be coated or infused with cannab inoids, including cannabi diol ("CBD"), extracted from a Cannabis plant. The CBD oil may be applied to a surface of each layer of the plurality of layers of the absorbent article, orthe CBD oil may be infused between the plurality of layers of the absorbent article.

In United States patent no. 10,765,848 to Dimino et al., a device for the topical treatment of pain affecting the vulvar area of the female human genital organ is disclosed. The device is a layered article shaped to be placed in a female undergarment and at least partially in contact with the skin of the female vulvararea, the device comprising a topical formulation. The device comprises a formulation- impermeable outer layer, a carrier layer not adhered to the outer layer in an area def ined by a channel of a rim layer, leaving a void space betweenthe two layers and thereby forming a channel into which a topical formulation may be released and distributed therein. A dispensing unit may be placed adjacent the channel, the dispensing unit comprising a pouch that will rupture when pressure is applied to the pouch by the user, and release the formulation contained in the pouch into the channel. The formulation released by the dispensing unit into the channel is absorbed into the carrier layer and transported to the skin-contacting surface of the carrier layer and thereby administered to the treatment area of the user. In the international publication no. WO 2020/026209 by applicant Anne's Day Limited, a catamenial tampon for absorb ing menstrual flow and for treating menstrual symptoms is disclosed. The tampon has an absorbent tampon body made of industrial hemp fiber. The tampon body is provided with a pharmaceutical composition comprising an effective amount of cannabidiol for treatment of symptoms associated with menstruation.

In United States patent application no. 15/012,045 by applicant Axim Biotechnologies, Inc., a sugar alcohol and cannabinoid complex is disclosed, as well as methods to prepare the complex from cannab inoid oil comprising at least one cannabinoid. The complex is in asolid form, and may be used in food, pharmaceutical, cosmeticformulations, and medical devices wherein solid forms of cannabinoid are desirable.

Summary

Presently disclosed herein is an article for the metered dispens ing of therapeutic substances to a person's skin, located particularly in the pelvic, pubic, genital, per ineum and/or anal areas of the person, for the topical treatment via the person's skin in those areas. In one aspect, the treatment is administered by a disposable undergarment, such as a disposable all-in-one thong, which incorporates an effective amount of a therapeutic substance, such as cannabidiol ("CBD") oil, suspended in asolid oil .

The article may have a sandwich construction comprising of several layers. In some embodiments, the layersinclude afluid permeabletop sheet positioned adjacent the user's skin when the article is worn by the user; an absorbent polymer layer for absorption of the user's bodily fluids, and atherapeutic substance layer sandwiched between the absorbent polymer layer and the top sheet. When the person's bodily fluids pass through the top sheet and the therapeutic substance layer into the absorbent polymer layer, the absorbent polymer layer absorbs the person's bodily fluids, which causes the absorbent polymer layer to swell and expand. As the absorbent polymer layer swel ls and expands, the absorbent polymer layer thereby propels the therapeutic substances contained in the therapeutic substance layer through the top sheet and into contact with the user's skin that is adjacent the top sheet of the article.

In another aspect, the therapeutic substances contained in the therapeutic substance layer may include compositions comprising a solid oil, the solid oil having a solid phase at room temperature and a liquid phase at skin surface temperature. The composition may also include one or more therapeutic substances combined with or suspended in the solid oil. When the solid oil is brought in proximity to the user's skin, the temperature of the solid oil increases and causes the solid oil to melt into a liquid phase, which enables the liquid phase to be propelled by the swol len and expanded absorbent polymer layer through the top sheet and into contact with the skin of the user adjacent the top sheet.

In some embodiments, the therapeutic substances include CBD oil. The therapeutic substances may also include, but are not limited to, vitamins, othertypes of oils, emollients, hormones, drugs, plant extracts, microorganisms and the like.

In one aspect of the present disclosure, a delivery article for the metered delivery of a therapeutic substance toa user'sskin, particularly in the user's pelvic, pubic, genital, perineum, anal areas and the like, comprises a layered sandwich construction, the sandwich construction coveringone or more of the said areas of the user when the article is worn by the user. The sandwich construction comprises: a fluid permeable top sheet, the top sheet positioned adjacent the said skin of the user when the article is worn by the user; an absorbent polymer layer for absorption of the user's bodily fluids; and a therapeutic substance layer sandwiched between the absorbent polymer layer and the topsheet. The layer of absorbent polymer is adapted so that absorption of the bodily fluids causes the absorbent polymer layer to swell. When the absorbent polymer layer swells, an absorbent polymer of the absorbent polymerlayerpropelsatherapeutic substance of thetherapeutic substance layerthrough the top sheet and onto the skin of the user adjacent the top sheet.

Some embodiments of the layered sandwich construction include a hydrophobic back sheet forming a layeron the opposite side of the absorbent polymer layer, opposite the top sheet and the therapeutic substance layer, wherein the bodily fluid is repelled by back sheet into the absorbent polymer layer. The article may also include a removable protective film adapted to cover an upper surface of the top sheet, wherein the user removes the protective film from the top sheet prior to using the article. The top sheet layer may be non-woven, and the top sheet may be perforated. For embodiments having a perforated top sheet, the perforations may be sized so as to meter a desired dispension rate of the therapeutic substancethroughthetopsheetand ontotheskin of the user adjacent the top sheet when the article worn by the user. The top sheet may be embossed and/or include a printed pattern.

Regard ing the absorbent polymer layer, in some embodiments the absorbent polymer is a super absorbent polymer. Regarding the therapeutic substance layer, in some embodiments this layer is a com position comprising a solid oil, the solid oil having a solid phase at room temperature and a liquid phase at skin surface temperature, and a therapeutic substance, wherein when the article comes into contact with the user's skin, the solid oil is heated by the user's skin and transitions from the solid phase to the liquid phase. The solid oil may be an emollient substance, and the emollient substance may be selected from a group comprising: coconut oil, shea butter oil, coconut butter, shea butter, hemp butter. The therapeutic substance may include cannabidiol oil, and in some embodiments the therapeutic substance consists solely of cannabidiol oil .

In some embodiments, the composition may further comprise one or more oils selected from the group comprising: almond oil, argon oil, avocado oil, azulene oil, borage seed oil, coconut oil, canola oil, castor oil, cottonseed oil, emu oil, evening pri mroseoil, flaxseed oil, kri ll oil, hemp oil, grapefruit seed extract oil, grapeseed oil, lavenderoil, lemon verbena oil, olive oil, omega 3 oils, palm oil, peril la oil, peanut oil, safflower oil, saffron oil, sesame oil, soybean oil, sunflower oil, starflower oil, rice bran oil, gamma oryzanol, hiprosehip oil, verbena oil, walnut oil, essential oil extracted from any one of herbs, spices, flowers seeds or plants. In some embodiments, the composition further comprises a probiotic solution containing Iactobacillus acidophilus for restoring or maintaining the vaginal microbiome of the user. The composition may comprise, in some embodiments, a solution selected from the group comprising: antifungal medicine, antimycotic medicine, for treatment of fungal overgrowth of the user. In some embodiments, the composition may further comprise estrogen and progesterone for restoration of the female hormone balance of the user, and in other embodiments the composition may comprise testosterone for restoration of the male hormone balance of the user.

In some embodiments, the composition may comprise a mixture selected from the group comprising: aloe vera. Vitam in C, glycer ine, collagen cream for i mproving the user's skin health. In stil l other embodiments, the composition may comprise one or more substances selected from the group comprising: vitamin B, thiam in, riboflav in, niacin, pantothenic acid, folate, biot in, cobalam in, z inc, vitam in A, vitam in D, indole 3 carbinol, maca, milk thistle, valerian root, licorice root, ginseng, red ginseng, flaxseed, dehydroepiandrosterone (DHEA), s inesis leaf, calcium D, glucarate, green tea extract (Camellia S inensis), melatonin, curcuma longa, rhizome curcuminoids, di indolylmethane (DIM), rosemarinus official is leaf, ginkgo bi loba extract, brassica oleraceavar. Italica sprout, hesperidin, choline (citarate), tribulusterrestris, gamma oryzanol, dong quai, L-Argine , hydrochloride, lavender, verbena, black cohosh, soy, ashwagandha, sage leaf extract, tongkat ali extract, gamma-am inobutyric acid (GABA), raspberry leaf extract, chaste berry extract (vitex agnus-castus), red clover, gelatine, seaweed, plants, fermented products, or comb inations thereof.

In still other embodiments, the article may be a liner adapted to temporarily adhere to an inner surface of an undergarment, wherein an outer surface of the back sheet of the article, opposite the absorbent polymer layer, includes a pressure-sensitive adhesive for adhering the liner to the inner surface of the said undergarment. In other embodiments, the article may be a disposable garment, the disposable garment selected from a group comprising: thong, thong hav ing a front triangle panel, snugly fitting briefs, high waisted briefs, undergarment, diaper.

Brief Desccription of the Drawings

FIG. 1A is a front perspective view of a thong embodiment in accordance with the present disclosure.

FIG. IB is a close up sectional viewof the thong embodiment of FIG. 1A taken along line IB- IB, showing the different layers of the thong.

FIGS. 1C to 1G are top plan cut-away viewsof the thong embodiment of FIG. 1A, showing the top sheet, therapeutic layer, absorbent polymer layer, hydrophobic back sheet, and removable protective film layers, respectively, of the thong embodiment.

FIG. 2A is a front perspective cut-away viewof another thong embodiment having a front triangle panel and show ing the therapeutic substance layer.

FIG. 2B is a sectional view of the embodiment shown in FIG. 2A taken along line 2B-2B.

FIG. 3A is a front perspective cut-away view of a snug briefs embodiment, showing the therapeutic substance layer.

FIG. 3B is a sectional view of the embodiment shown in FIG. 3A taken along line 3B-3B.

FIG. 4A is a front perspective cut-away view of a high waisted briefs embodiment, showing the therapeutic substance layer.

FIG. 4B is a sectional view of the embodiment shown in FIG. 4A taken along line 4B-4B.

FIG. 5A is a front perspective cut-away view of a full briefs embodiment, showing the therapeutic substance layer. FIG. 5B is a sectional view of the embodiment shown in FIG. 5A taken along line 5B-5B.

FIG. 6A is a top plan cut-away view of a liner embodiment, showing the therapeutic substance layer.

FIG. 6B is a sectional view of the embodiment shown in FIG.6 taken along line 6B-6B.

FIG. 7A is a top plan cut-away view of a thong liner embodiment, showing the therapeutic substance layer.

FIG. 7B is a sectional view of the embodiment shown in FIG. 7 taken along line 7B-7B.

Detailed Descri ption

The various embodiments of the article disclosed herein are configured for delivering the topical application of one or more the rapeuticsubstances to the user's pelvic, pubic, genital, per ineum and/or anal areas, and the like, for treating various conditions and/or maintain ing or improving the health of those areas of the user. Preferably, the articles are intended for single use and are disposable. As will be further described below, some of the embodiments are disposablegarments intended for single use, while otherembodiments are liners, padsand the likefortemporarily attachingoradheringtothe inner surface of a non-disposableundergarment. Such articles may be worn by males, femalesand persons of other genders. As will also be explained below, the articles include an absorbent polymer layerfor absorb ing bodily fluids, which bodily fluids may include but are not limited to menstrual blood and fluids, vaginal discharge, urine and sweat.

In one aspect, the therapeutic substance comprises, or consists solely of, CBD oil. CBD oil is known to have anti- inflammatory properties, anti-fungal properties, and to aid in healing. The application of CBD oil to a person's pelvic, pubic, genital, perineum and/or anal areas may include but are not li mited to therapeuticusesfor reducingorprevent ingthe development of cancer cells; as an anti-emeticto help with nausea; and to assist with the mild rejuvenation of an atrophic vagina which may occur through the loss of hormones. For females, the application of CBD oil to the genital area may relieve premenstruation and menstruation symptoms, including but not limited to cramps and nausea. Furthermore, the application of CBD oil to the genital area and the perineum may assist in healing after surgery or childbirth and may assist with healing tears in the perineum. For males, the application of CBD oil to the genital area may also have therapeutic benefits, including but not limited to aiding in healing after a vasectomy. Forboth malesandfemales, the application of CBD oil to the genital, pelvic. pubic, perineum and/or anal areas may also assist in treatment of eczema, rashes caused by urinary incontinence or excessive perspiration, and may be useful in the treatment of rashes caused by a fungal infection, such as jock itch or ringworm. Furthermore, the application of CBD oil to the genital area may be advantageous while travelling or partaking in sports.

Referring to FIGS. 1A to 1G, one illustrated embodiment of the article includes an all-in-one disposable thong garment 100. Thong 100 includes an elasticized waistband 102, a back sheet layer 104 and a top sheet layer 106, the back and top sheet layers 104, 106 together encasing a layered sandwich construction of multi ple layers including the therapeutic substance layer, as will be further described below. The elasticized waistband 102 may include one or more fasteners 108, which may for example include hook and loop fasteners, such as Velcro™.

The top sheet layer 106 is a fluid permeable top sheet that is positioned against the skin of the user when the thong garment 100 is worn. A crotch portion 106c of the fluid permeable top sheet layer 106 encases the absorbent and therapeutic substance layers of the thong 100, which layers are il lustrated in FIGS. IB to 1G. Adjacent the crotch portion 106c of the top sheet layer is a rear portion 106a extending towards and attached to the waistband 102 at the rear si de of the thong 100, and simi larly an adjacent front portion 106b of the top sheet layer extends towards and attached to the waistband 102 at the front side of the thong 100. The fluid permeable top sheet 106 may be of a non-woven material and allows bodi ly fluids to pass through the top sheet. The bodily fluids may be filtered by the top sheet 106. In some embodiments, the top sheet 106 may be embossed with a pattern, which may be aesthetically pleas ing, and may also serve to provide channels orgrooves for receiving and directing bodily fluids of the user. The top sheet layer 106 may also be printed with a pattern.

Directly beneath the top sheet layer 106 is a therapeutic substance layer 114. The therapeutic substance Iayer ll4 may include a composition of therapeutic substances, including but not limited to CBD oil, as well asothertherapeutic substancesthat are described elsewhere in the present disclosure. Thetherapeutic substances may be suspended in one or more solid oils, which are oils that are in a solid phase at room temperature, for example in the range of 20“C to 23°C, and which transition to a liquid phase at body temperature, for example in the range of 34.7°C to 38°C. Advantageously, the composition may contain specific amounts of one or more therapeutic substances in specific concentrations and in combination with one or more solid oils, so as toform pellets or a coating 114a, thereby creating a layer underneath the top sheet of the sandwich construction. The composition, in the form of a solid oil mixture, may be carried on a substrate 114b, such as a woven or non-woven material . In some aspects, the solid oil mixture may be placed into the therapeutic substance Iayer 114 at vary ing depths, using an accurate dose, automated liquid injecting dispensing system. The solid oil mixture may be contained in a strip along a center line of the therapeutic substance layer 114, or in other embodiments the solid oil mixture may cover a portion of or the entire area of the therapeutic substance layer 114.

Prior to use of the article, the solid oil mixture or composition re mains in the solid phase. During use of the article, as the solid oil composition 114a is positioned proxi mate the body of the user, thereby transferring the user's body heat to the solid oil composition 114a so as to melt the solid oil composition 114a into a liquid phase. The transfer of the user's body heat may occur by a combination of transfer from the user's skin and/or any bodily fluids discharged by the user, which bodily fluids passthrough the top sheet 106and into the therapeutic substance Iayer ll4.

Beneath the therapeutic substance layer 114 is an absorbent polymer layer 116, containing an absorbent polymer 116a. Preferably, the absorbent polymer 116a is a super absorbent polymer ("SAP"), which may be comprised of, for example, sodium polyacrylate. SAPsare materials which are capable of absorb ing up to 300 times their weight in aqueous fluids, and which do not release the aqueous fluids once absorbed. Due to this ability to absorb and contain a relatively large amount of aqueous fluids, which include bodily fluids, the SAPs swell and expand in volume upon absorbing aqueous fluids. In some embodiments, the absorbent polymer layer 116 may optionally include other absorbent materials, such as but not limited to pump, cotton, hemp and/or other absorbent fibers, to provide additional absorbency tothe absorbent polymer layer 116.

In some embodiments, the sandwich construction may optionally also include a hydrophobic back sheet 118. The hydrophobic back sheet 118 serves to repel the bodi ly fluids that filter through the top sheet 106 and preventthe passage of those fluids through the article 100. Additionally, some embodiments may optionally include a removable protective film layer 120, which layer 120 may be attached to the top sheet layer 106 by means of an adhesive. The protective film layer 120 serves to protect the disposable thong 100 from moisture or contaminants prior to use and to assist in conta ining the therapeutic substanceswithin the article. Therefore, the removable protective film layer l20 may be a hydrophobicsubstance such as a plasticfi lm ora wax coated paper. The I aye red sandwich construction, including the therapeutic substance layer 114, absorbent polymer layer 116 and the optional hydrophobic back sheet layer 118 may be encased by the top sheet layer 106c and the back sheet layer 104, as best viewed in FIG. 1B. It wil l also be appreciated that the back sheet layer 104 may be hydrophobic, in which case the hydrophobic back sheet layer 118 may not be included.

To use the disposable thong 100, if the disposable thong includes the optional protective film 120, the user removes the protective fi lm 120from the top sheet 112 before wearingthe thong 100. Once the user puts on the thong 100, the top sheet 106 is positioned snugly against the user's pubicand genital areas. As the user wears the thong 100 for a period of time, any bodily fluids of the user will be captured by and filter through the fluid permeable top sheet 106 as the fluids are pul led downwardly through the top sheet by gravity. The user's body heat, radiating from the skin of the user and from the user's bodily fluids, will transfer to the solid oil composition 114a of the therapeutic substance layer 114, thereby transitioning the solid oil composition 114a from the solid phase to the liquid phase. The bodily fluids released by the user wi ll pass through the therapeutic substance layer 114 to the absorbent polymer layer 116, where the bodily fluid will be absorbed by the absorbent polymer 116a, which may include SAP. Any excess bodi ly fluid that initially passes through the absorbent polymer layer wi ll be repelled by the hydrophobic back sheet 118, in embodiments that include a hydrophobic back sheet 118, and may also be thereby absorbed by the absorbent polymer layer 116. As the absorbent polymer orSAP 116a absorbs the bodilyfluid, it wil l swell and expand in volume, thereby push ing upwardly on the therapeutic substance layer 114. As a result, the swelling absorbent polymer layer 116 propels the solid oil composition 114a, containing the therapeutic substances, towards and through the top sheet 106, as the solid oil composition 114a has melted intothe liquid phase, therebyfacilitatingthe transport of the solid oil composition 114a through the fluid permeable top sheet layer 106. The solid oil composition 114a thereby comes into contact with the user's skin that is adjacent the top sheet layer 106, accomplish ing the topical application of the therapeutic substance contained in the solid oil composition to the user's skin intheirgenital and pelvic areas.

In some embodiments, the top sheet 106 may include perforations for controlling the flow of the therapeutic substancesthat passesthrough the top sheet layer 106 to come into contact with the user. The size of the perforations may be adjusted to control the metering of the dosage of the therapeutic substance delivered to the user'sskin surface.

Additional embodiments of the article, such as those illustrated in FIGS. 2A to 7B, operate in a similar manner to the disposable thong 100 illustrated in FIGS. lAto 1G. The different embodiments shown in FIGS. 2A to 7B provide for different styles and fits of disposable undergarments, as well as different configurations of disposable pads or liners for adhering to the inner surface of a non-disposable undergarment. Different styles and fits of disposable undergarments may advantageously be tailored for use by different genders and ages of people, and may target different areas of the user's skin. Although not illustrated, it wil l be appreciated that the article may also include disposable diapers for use on young chi ldren or adults who suffer from incontinence. The central or crotch portion of each embodiment, where the layered sandwich construction is positioned, may be tai lored for delivering therapeutic substances to differentareas of a person's genital, pelvic, pubic, perineum and/oranal areas and the like.

FIGS. 2A and 2B illustrate another embodiment of a disposable thong 200, the disposable thong 200 having a front triangle panel 210 containing the layered sandwich construction. The front triangle panel 210 comprises a top sheet Iayer 212, a therapeutic substance Iayer 214, an absorbent polymer layer 216 and a hydrophobic back sheet 218. The design of the front triangle panel 210 provides for greater contact area betweenthe user's pubicand pelvicareasandthetop sheetthatdispensesthetherapeutic substance to the user's skin, as compared to the relatively smaller crotch portion 106a illustrated in FIGS. 1A to 1G.

FIGS.3A and 3B illustrate a disposablesnug briefs embodiment 300. The central portion 310 covers the crotch area of the briefs 300, and comprises a top sheet layer 312, a therapeutic substance layer 314, an absorbent polymer layer 316 and a hydrophobic back sheet 318.

FIGS.4A and4B i llustrate a disposable high waisted briefs embodiment 400. The front and crotch panel 410 covers the entire front and crotch portions of the garment, and may optionally extend to the back portion of the garment, so as to provide full contact between the user's public, pelvicand anal areas and the top sheet 412 that dispenses the therapeutic substance to the user's skin. The front and crotch panel 410 also comprises a therapeutic substance layer 414, an absorbent polymer layer 416 and a hydrophobic back sheet 418.

FIGS. 5A and 5B illustrate a disposable full briefs embodiment 500. The front and crotch panel 510 covers the entire front and crotch portions of the garment, and may optional ly extend to the back panel of the garment, so as to provide full contact betweenthe user's pubic, pelvic and anal areas and the top sheet 512 that dispenses the therapeutic substance to the user's skin. The front and crotch panel 510 also comprises a therapeutic substance layer 514, an absorbent polymer layer 516 and a hydrophobic back sheet 518. Although not shown, each of the illustrated embodiments, including the disposable thong 200, disposable snug briefs 300, disposable high waisted briefs 400 and the disposable ful l briefs 500, may optionally include a protective film.

FIGS. 6A and 6B illustrate a disposable sanitary pad embodiment 600, compris ing a top sheet 612, a therapeutic substance layer 614, an absorbent polymer layer 616 and a hydrophobic back sheet 618. Optional ly, the hydrophobic back sheet 618 may include a pressure sensitive adhesive 618a applied to an outersurface of the hydrophobicbacksheet, foradheringthesanitary pad 600 to the crotch panel of the user's underwear. Similarly, FIGS. 7Aand 7B illustrate a disposable liner 700, comprisinga top sheet 712, a therapeutic substance layer 714, an absorbent polymer layer 716 and a hydrophobic back sheet 718. Optionally, the hydrophobic back sheet 718 may include a pressure sensitive adhesive 718a applied to an outersurface of the hydrophobic back sheet, for adher ing the liner 700 to the crotch panel of the user's underwear. Although not i llustrated, each of the pad 600 and the liner 700 may optionally include a protective film layer.

In another aspect, the article may be used for the metered delivery of therapeutic substances in addition to CBD oil, or other than CBD oil, to a person's pelvic, pubic, genital, per ineum and/or anal areas and the like. For embodiments having therapeutic substances that include CBD oil, the article may replace regular feminine hygiene products, such as panty liners or menstrual pads, as well as replace overthe counter medications for relieving menstruation cramps and other menstrual symptoms, such medications including Tylenol™ or Ibuprofen; antiemetic medication (such as Gravol™), as such menstrual symptoms are caused by a high level of prostaglandins present at the start of a menstrual period which causes the uterus to contract to help expel its lining. High levels of prostagland ins in the user may cause inflammation andtriggerthe uterinemuscle contractions. The CBD oil may also relieve nausea caused by cancertreatment, for example for a user seeking treatment for cervical or other types of cancer, and the CBD oil may furthermore provide therapeutic treatment for the anti- prolife rati on of cancer cel ls. Additionally, CBD oil may be used to promote rejuvenation for an atrophic vagina and to relieve light ur inary incontinence that results from hormone loss, childbirth, cancer treatment and/or menopause. Benefits of using articles incorporating CBD oil in the therapeutic substance layer additional ly include, but are not limited to: not nee d ign to orally ingest pain medication tablets; and no messy applications of CBD oil-containing gel, foam, or cream that would usually be applied with the fingers or an applicator. Advantageously, in some embodiments the CBD oil contained inthe article includesa measured dose of CBD oil that is administered by an automated measured liquid dispenser. therefore it is not left to the individual to guess the correct dosage of CBD oil, which is instead a controlled dose of CBD oil administered via the product.

In some embodiments, the therapeutic substances may include a probiotic solution containing live microorganisms, including but not limited to Lactobacillus Acidophilus, in combination with a solid oil and/orCBD oil, and further additions that will be listed below, may be used to help restore the natural bacteria and other microorganisms present in the vagina and thereby hel p prevent yeast infections. As persons skiilld in the art will be aware, it is known that mainta ining the vagina microbiome in balance with "friendly" bacteria and other microorganisms that are naturally present in the digestive system, the urinary system and the reproductive system is important to maintaining good vaginal health, and the absence of friendly bacteria in the vagina may lead to an overgrowth of fungi, which may result in a yeast infection known as Candida, as wel l as diarrhea, nausea, autoimmune diseases, mood disorders, and skin problems that may be associated with low levels of friendly bacteria.

In some embodiments, the therapeutic substances may include a mixture of antifungal or an anti mycotic solution with asolid oil and/or CBD oil and other ingredients, as discussed below, may be used for the curing of fungi overgrowth, such as Candida and Tinea Cruris (also known as Jock itch or Ringworm of the groin and genital areas).

In some embodiments, the therapeutic substance may include a mixture of the female hormones Estrogen and Progesterone, either derived from phytoestrogens or synthetic hormones, as well as starflower oil, evening primrose oil, in combination with a solid oil and/or CBD oil, and/or other ingredients as discussed below, may be used inthe articleto help promote menstrual regularity, reduce menstrual flow, relivethe pain of menstrual cramps, and assist the balancing of female hormones of the user.

In some embodiments, thetherapeutic substance may include a mixture of Testosterone, either de rived from phytoestrogens, orsyntheticmade hormone, used in combination with a solid oil and/or CBD oil, and/or other ingredients as discussed below, may be used to help improve sexual interest and improve performance and stamina and assist in the balancing of male hormones of the user.

In some embodiments, the therapeutic substance may include a mixture of Aloe Vera, Vitamin C (Ascorbic Acid), glycerine, and collagen cream, in combination with a solid oil and/or CBD oil, and/or otheringredients as discussed below, which mixtures may be used to remove or reduce ingrown hairs. increase the softness and smoothness of the skin, as we 11 as the plumpness, firmness, and brightness of the skin in the genital area.

Examples of solid oils for hoi d ign the CBD oil and other ingredients in suspension include, but are not li mited to: coconut oil, shea butter oil, shea butter and coconut butter. Other examples of butters or compounds, whether natural or synthetically made, which may be used as solid oils for hold ing the CBD oil and otheringredients in suspension in the therapeutic substances layer include, but are not limited to: Shea butter. Coconut butter. Hemp butter, or any blend of emollient butters.

Additional natural orsynthetic made oils, foremulsification and therapeutic benefits and which may be included in the mixture of therapeutic substances, include but are not limited to: Almond oil. Argon oil. Avocado oil. Azulene oil. Borage seed oil. Coconut oil. Canola oil. Caster oil. Cottonseed oil. Emu oil. Evening Primrose oil. Flaxseed oil. Kri ll oil. Hemp oil. Grapefruit seed extract oil. Grapeseed oil. Lavender oil. Lemon Verbena oil. Olive oil. Omega 3 oils. Palm oil. Perilla oil. Peanut oil. Safflower oil. Saffron oil. Sesame oil. Soybean oil. Sunflower oil. Starflower oil. Rice Bran oil, (Gamma Oryzanol), Rosehip oil. Verbena oil. Wal nut oil, essential oils from herbs, spices, flowers seeds or plants.

Additional ingredients for inclusion in the therapeutic substances include, but not limited to. Vitam ins, minerals, trace elements or plant based compound, mixture, solution, orsuspension, such as: Vitam in B, Thiamin, Riboflavin, Niacin, Pantothenic acid. Folate, Biotin, Cobalamin, Z inc, Vitamins C, Aand D, Indole 3 carb inol, Maca, Milk Thistle, Valerian Root, Licorice Root, Ginseng, Red Ginseng, Flaxseeds, Dehydroepiandrosterone (DHEA), Sinesis Leaf, Calcium D, Glucarate, Green Tea extract (Camellia Sinensis), Melaton in, Curcuma Longa, Rhizome Curcum inoids, Diindolyl methane (DIM), Rosemar inus Official is Leaf, Ginkgo Bi loba extract. Brassica Oleraceavar. Italica sprout, Hesperidin, Pantothenic Acid, Chol ine (Citarate), TribulusTerrestris, Gamma Oryzanol, DongQuai, L-Argine, Hydro chloride, Lavender, Verbena, Black Cohosh, Soy, Ashwagandha, Sage leaf extract, Tongkat Ali extract, Gaba Am inobutyric Acid, Raspberry Leaf extract. Chaste berry extract (Vitex Agnus-Castus), Red Clover, gelat ine, seaweed, plants, fermented products, or comb inations thereof.